采用柱切换色谱-离子阱质谱联用法研究复方丹参滴丸中丹参素及其代谢产物

采用柱切换高效液相色谱技术对人血清中的丹参素及其代谢产物进行富集和分离,利用对电喷雾离子阱多级质谱负离子模式进行结构分析。一级流动相为甲醇-水(30：70,V/V),流速0．8mL／min;二级流动相为甲醇-水-甲酸铵(15：85：0．5,V/V/V),流速0．2mL／min;在人血清中检测到丹参素及其代谢产物,并探讨了主要代谢产物乙酰化的丹参素(m/z 240．2)。建立一种复方丹参滴丸中丹参素及其代谢产物在人体内代谢过程的高效分析方法。该方法可用于复方丹参滴丸中丹参素及与其结构类似的其它药物的体内代谢研究。     

中药指纹图谱的融合技术

中药指纹图谱作为中药材真伪鉴别及质量控制的有效手段,具有整体、宏观和模糊分析等特点。高效液相色谱是指纹图谱研究的主流方法,在中药质量控制中具有重要地位。针对栀子药材而言,包括3类主要物质：环烯醚萜苷类、有机酸类和色素类。仅采用一个特征波长下的色谱指纹图谱无法对栀子药材进行整体表达和全面评价。为此,     

227-W output all-fiberized Tm-doped fiber laser at 1908 nm

In this paper, we report that a diode-pumped thulium-doped double clad silica fiber laser can provide powers of up to 227 W at 1908 nm, corresponding to a slope efficiency of 54.3%, and an optical-to-optical efficiency of 51.2%. The output power, to the best of our knowledge, is the highest output at 1908 nm. The beam quality M2 factor is about 1.56. Also discussed in this paper is the dependence of the laser performance on fiber length.     

超高速撞击数值仿真结果分析

为了分析超高速撞击过程的宏观现象和内在机理,对9.53 mm铝球以6.64 km/s的速度撞击2.2 mm厚的铝靶的SPH仿真结果进行了量化分析。结果表明:采用SPH方法以及Steinberg弹塑性模型和Mie-Grneisen状态方程,可获得与试验相符的仿真结果;球形破片开坑或穿孔直径遵循初始快速增加、然后缓慢增加,直至稳定的变化规律;破片/靶板界面的最大撞击压力比材料强度大两个量级以上;靶板阻抗力最大值发生在破片最大直径侵入靶板时刻;碎片云的运动过程具有自相似演化特征,其运动范围不会超出碎片云的包络圆锥范围。     

Feasibility study on cross-section measurement of Y（1S） →μ^＋μ- by using early CMS data

One of the first physics results that CMS will hopefully obtain will be the analysis of heavy quarkonium productions, including the Υ cross-section measurement. Since the Υ production cross-section from p-p collisions is expected to be relatively large, the analysis should be viable with rather small datasets which will be available soon after the start-up of the LHC. This paper describes the methods and plans for measuring the differential cross-section of Y（1S） →μ^＋μ- production, by using data to be collected from the CMS detector in the first LHC run. In this study, about 80 thousand Υ are reconstructed corresponding to an integrated luminosity of 6.4 pb^-1 in 10 TeV proton-proton collisions by using Monte Carlo data. The precision of this measurement is estimated to be about 16%, which is limited by the systematic errors.     

Multi-bubble motion behavior of uniform magnetic field based on phase field model

Aiming at the interaction and coalescence of bubbles in gas–liquid two-phase flow, a multi-field coupling model was established to simulate deformation and dynamics of multi-bubble in gas–liquid two-phase flow by coupling magnetic field, phase field, continuity equation, and momentum equation. Using the phase field method to capture the interface of two phases, the geometric deformation and dynamics of a pair of coaxial vertical rising bubbles under the applied uniform magnetic field in the vertical direction were investigated. The correctness of results is verified by mass conservation method and the comparison of the existing results. The results show that the applied uniform magnetic field can effectively shorten the distance between the leading bubble and the trailing bubble, the time of bubbles coalescence, and increase the velocity of bubbles coalescence. Within a certain range, as the intensity of the applied uniform magnetic field increases, the velocity of bubbles coalescence is proportional to the intensity of the magnetic field, and the time of bubbles coalescence is inversely proportional to the intensity of the magnetic field.     

轴向配体对Rh2(OAc)4电子结构和氧化还原电位的影响

本文研究了Rh2(OAc)4配合物在14种非水溶剂中的电子吸收光谱和氧化还原行为.在弱σ-给电子配位体(二氯甲烷、二氯乙烷、丙烯碳酸脂、丙酮、四氢呋喃、N,N-二甲基甲酰胺、丁腈、乙腈苯乙腈和硝基甲烷)情况下,Rh2(OAc)4同其形成溶剂化轴向配合物的氧化电位基本不变.然而,当强σ-给电子配体(吡啶、二甲基亚砜、亚磷酸三乙酯和三苯基膦)与Rh2(OAc)4形成轴向配合物时,产物的氧化电位明显地向阴极方向移动.用两种不同的电子构型解释了电化学数据以及Rh2(OAc)4轴向配合物的中性分子和阳离子游离基电子吸收光谱特征.14种溶剂给电子配位能力有如下顺序:二氯甲烷～二氯乙烷<丙烯碳酸脂<丙酮～四氢呋喃相似文献   

新双硫代甲酸盐衍生物的合成

双硫代甲酸盐可用作抗菌剂,橡胶硫氏剂,也是过渡金属的良好配位体。但是大多数研究都只限于脂肪族一元胺衍生物,本文报道芳香族及脂肪族多元胺的双硫代甲酸盐的合成。产物的红外光谱,核磁共振谱和元素分析结果列于附表。