强韧化材料的细观力学设计

本文主要阐述强韧化材料细观力学设计的基本概念和方法、力学模型和关键技术．探讨建立材料优化设计模型的可能途径．特别强调面向计算机的材料性能定量设计方法和材料细观力学设计的软件系统．评述当前在该领域内的若干研究进展      

A CAD oriented quasi-analytical large-signal drain current model for 4H-SiC MESFETs

This paper reports that a 4H-SiC MESFET (Metal Semiconductor Field Effect Transistor) large signal drain current model based on physical expressions has been developed to be used in CAD tools. The form of drain current model is based on semi-empirical MESFET model, and all parameters in this model are determined by physical parameters of 4H-SiC MESFET. The verification of the present model embedded in CAD tools is made, which shows a good agreement with measured data of large signal DC I-V characteristics, PAE (power added efficiency), output power and gain.     

CAD-CAE及3D打印在《塑料制品设计》课程教学中的应用探索

在工科学生培养过程中引入先进的CIDO工程教育模式,对培养学生的实践能力和创新能力具有重要的作用和意义。本文在分析《塑料制品设计》课程教学特点的基础上,将工程实践中广泛应用的CAE/CAE技术引入课程教学,并进行了有益的探索,不仅对提高该课程教学效果有重要意义,同时可以促使学生学习和应用CAD/CAE软件。在此基础上,将制造业领域迅速发展的3D打印技术应用到课程教学,有助于学生了解先进技术,激发学生的学习兴趣并提高学生的创新能力。     

行波管相位一致性的理论研究与计算机模拟

 采用行波管一维大信号非线性理论,建立了高频参数和外部工作状况零散模型,对影响增益、相位频率特性的主要因素进行了理论分析和数值计算,分析了如何合理地选择相位一致行波管工作点,为新近研制的相位一致行波管提供了计算机模拟并得到了很有价值的计算结果。     

Knowledge-Based Artificial Neural Network Models for Microstrip Radial Stubs

Radial stubs are a superior choice over low characteristic impedance rectangular stubs in terms of providing an accurate localized zero-impedance reference point and maintaining a low input impedance value over a wide frequency range. In this paper, knowledge-based artificial neural networks are used to model the microstrip radial stubs. Using space-mapping technology and Huber optimization make the neural network models for radial stubs decrease the number of training data, improve generalization ability, and reduce the complexity of the neural network topology with respect to the classical neuromodeling approach. The neural networks are developed for design and optimization of radial stubs, which are robust both from the angle of time of computation and accuracy.     

一种基于有限元网格的车身CAD曲面数据修复方法

针对车身CAD中非同构数据格式间的转换使自由形体的近似值发生变化而导致曲面片之间产生缝隙或网格叠加的情况，提出了一种基于有限元网格、应用于车身CAD曲面网格数据自动修复的方法。该方法还能够在一定程度上局部修复原来划分有缺陷的网格，从而降低对车身CAD模型有限元网格划分的质量要求，并通过工业复杂成形件的实际处理结果验证了该方法的有效性。     

Determination of lipid content and stability in lipid nanoparticles using ultra high-performance liquid chromatography in combination with a Corona Charged Aerosol Detector

For many years, lipid nanoparticles (LNPs) have been used as delivery vehicles for various payloads (especially various oligonucleotides and mRNA), finding numerous applications in drug and vaccine development. LNP stability and bilayer fluidity are determined by the identities and the amounts of the various lipids employed in the formulation and LNP efficacy is determined in large part by the lipid composition which usually contains a cationic lipid, a PEG-lipid conjugate, cholesterol, and a zwitterionic helper phospholipid. Analytical methods developed for LNP characterization must be able to determine not only the identity and content of each individual lipid component (i.e., the parent lipids), but also the associated impurities and degradants. In this work, we describe an efficient and sensitive reversed-phase chromatographic method with charged aerosol detection (CAD) suitable for this purpose. Sample preparation diluent and mobile phase pH conditions are critical and have been optimized for the lipids of interest. This method was validated for its linearity, accuracy, precision, and specificity for lipid analysis to support process and formulation development for new drugs and vaccines.     

Shape recovery for sparse‐data tomography

A two‐dimensional sparse‐data tomographic problem is studied. The target is assumed to be a homogeneous object bounded by a smooth curve. A nonuniform rational basis splines (NURBS) curve is used as a computational representation of the boundary. This approach conveniently provides the result in a format readily compatible with computer‐aided design software. However, the linear tomography task becomes a nonlinear inverse problem because of the NURBS‐based parameterization. Therefore, Bayesian inversion with Markov chain Monte Carlo sampling is used for calculating an estimate of the NURBS control points. The reconstruction method is tested with both simulated data and measured X‐ray projection data. The proposed method recovers the shape and the attenuation coefficient significantly better than the baseline algorithm (optimally thresholded total variation regularization), but at the cost of heavier computation.     

Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector

A mixed-mode chromatography coupled with charged aerosol detector (CAD) method was developed in this work to simultaneously determine pharmaceutical counterions including both inorganic ions and organic ions in the forms of cations and anions. 25 commonly used pharmaceutical ions were studied and simultaneously separated within 20 min by this single method. A silica based mixed-mode column with reversed-phase/cation-exchange/anion-exchange modes was used. It provides reversed-phase, strong cation-exchange and weak anion-exchange properties at the same time. It also provides the HILIC behavior at high percentage of organic solvent. The effects of mobile-phase organic strength, buffer ions, ionic strength, pH and column temperature have been investigated to optimize the method as well as to understand the retention and separation mechanisms. Conventional HPLC system was used and no special chromatography system is needed. The presented method has been employed successfully for screening and quantitative analysis of counterions, unknown ionic impurities and salts in active pharmaceutical ingredients and in process control samples with excellent accuracy, precision and sensitivity. This method provides a simple, fast and generic approach to speed up pharmaceutical research and development process and enhance lab efficiency. The similar methodologies can be applied to other ion analysis.