Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Study on Sodium Azide Cluster Ions

Introduction Mass spectrometry (MS) has been an important technique for studying size-dependent cluster properties with unparalleled sensitivity, specificity, and versatil-ity.1,2 Especially Fourier transform ion cyclotron reso-nance (FT-ICR) MS offers the benefits of ultra-high mass resolving power, superior mass accuracy, and the ability of affording useful structure information with tandem MS. The introduction of electrospray ionization (ESI) as a gentle mode of ion generation for MS…     

A Neuro-Fuzzy Network for the Design of Circular and Triangular Equilateral Microstrip Antennas

A fast method for the design of circular and equilateral triangular microstrip antennas, based on a Neuro-Fuzzy Network, is presented. Numerical results obtained by using this technique agree quite well with the Moment Method results. The proposed technique can be fruitfully used in microwave and millimeter wave CAD applications.     

BBL布局的V一H树

本文首先定义一种有序有色的出树,称为V-H树。用该树描述BBL布局中的slicing结群。然后提出两种产生V-H树的递归构造法:一种是利用整数划分和迭代的方法,另一种是先分类再根据若干定理递归。最后讨论几种特殊树和BBL布局的关系。     

Analytical derivation of a nonlinear FET-equivalent-circuit for MMIC applications

A new method for the derivation of a FET-equivalent-circuit is presented in this paper. The model which is valid at least in the frequency range of 45 MHz to 26.5 GHz allows a large-signal simulation of the FET. The elements of the equivalent-circuit are calculated analytically from the measured scattering parameters of the FET.     

基于小波变换和图论方法识别乳腺微钙化点簇

成簇的微钙化点是早期乳腺癌的一个重要表征,用计算机辅助诊断时需要在乳腺片图像中判断有无钙化点簇。提出了一种利用Daubechies小波对乳腺图像进行增强,用二维熵阈值分割法对增强后的图像进行阈值分割,然后采用图论方法提取出成簇钙化点的方法。从而实现了计算机辅助诊断系统辅助医师判断恶性钙化。     

A New 3D Digitizer by Cutting and Scanning Layer by layer

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Difference in formation of carbon cluster cations by laser ablation of graphene and graphene oxide

The distributions of positive carbon cluster ions produced by laser ablation of graphene (G) and graphene oxide (GO) are found to be quite different. Under a typical experimental condition, narrow distributions of even‐numbered clusters from to were observed for G, and broad distributions including even‐numbered clusters from to and odd‐numbered clusters from to were observed for GO. The threshold of laser energy for G is lower than that of GO. Further results of collision‐activated dissociation mass spectrometry indicate that the cluster ions generated from G are structurally similar but are different with those generated from GO or nanodiamonds. It is proposed that the experimentally observed difference can be attributed to the different mechanisms behind the process. A top‐down mechanism including both direct transformation of G to fullerene and fragmentation of large‐sized fullerenes is suggested for the generation of carbon cluster cations in the process of laser ablation of G. For GO, the experimental results are close to those of nanodiamonds and other materials reported previously and can be explained by the generally accepted bottom‐up mechanism. Copyright © 2012 John Wiley & Sons, Ltd.     

Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector

A mixed-mode chromatography coupled with charged aerosol detector (CAD) method was developed in this work to simultaneously determine pharmaceutical counterions including both inorganic ions and organic ions in the forms of cations and anions. 25 commonly used pharmaceutical ions were studied and simultaneously separated within 20 min by this single method. A silica based mixed-mode column with reversed-phase/cation-exchange/anion-exchange modes was used. It provides reversed-phase, strong cation-exchange and weak anion-exchange properties at the same time. It also provides the HILIC behavior at high percentage of organic solvent. The effects of mobile-phase organic strength, buffer ions, ionic strength, pH and column temperature have been investigated to optimize the method as well as to understand the retention and separation mechanisms. Conventional HPLC system was used and no special chromatography system is needed. The presented method has been employed successfully for screening and quantitative analysis of counterions, unknown ionic impurities and salts in active pharmaceutical ingredients and in process control samples with excellent accuracy, precision and sensitivity. This method provides a simple, fast and generic approach to speed up pharmaceutical research and development process and enhance lab efficiency. The similar methodologies can be applied to other ion analysis.     

Carbon nanotubes as solid-phase extraction sorbents prior to atomic spectrometric determination of metal species: A review

New materials have significant impact on the development of new methods and instrumentation for chemical analysis. From the discovery of carbon nanotubes in 1991, single and multi-walled carbon nanotubes – due to their high adsorption and desorption capacities – have been employed as sorption substrates in solid-phase extraction for the preconcentration of metal species from diverse matrices. Looking for successive improvements in sensitivity and selectivity, in the past few years, carbon nanotubes have been utilized as sorbents for solid phase extraction in three different ways: like as-grown, oxidized and functionalized nanotubes. In the present paper, an overview of the recent trends in the use of carbon nanotubes for solid phase extraction of metal species in environmental, biological and food samples is presented. The determination procedures involved the adsorption of metals on the nanotube surface, their quantitative desorption and subsequent measurement by means of atomic spectrometric techniques such as flame atomic absorption spectrometry, electrothermal atomic absorption spectrometry or inductively coupled plasma atomic emission spectrometry/mass spectrometry, among others. Synthesis, purification and types of carbon nanotubes, as well as the diverse chemical and physical strategies for their functionalization are described. Based on 140 references, the performance and general properties of the applications of solid phase extraction based on carbon nanotubes for metal species atomic spectrometric determination are discussed.