共查询到20条相似文献,搜索用时 250 毫秒
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以1,6-二氢-6-哒嗪酮-3-甲酰肼(1)与芳香醛反应得到相应的1,6-二氢-6-哒嗪酮-3-羰基芳香醛腙(2a~2e). 再将2a~2e与乙酸酐作用, 合环得到一系列含有1,3,4-噁二唑啉环的衍生物3a~3e; 在DMF中用HSCH2COOH合环, 得到含有4-噻唑烷酮的衍生物4a~4e. 所有化合物的结构均经元素分析, IR, 1H NMR 和MS谱得以证实. 相似文献
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文献曾报道以铝-镍合金为还原剂, 在稀碱水溶液中, 可以将1-萘酚(1)以高收率还原为5,6,7,8-四氢-1-萘酚(2). 本研究工作发现, 在相同的条件下该反应除了生成少量2外, 3,4-二氢-2H-萘-1-酮(3)和1,2,3,4-四氢-1-萘酚(4)为主要产物, 该结果明显不同于文献报道, 对反应产物分布及其可能机理进行了探讨. 该还原反应体系为3,4-二氢-1(2H)-萘酮(3)和1,2,3,4-四氢-1-萘酚(4)的合成提供了一条新途径. 相似文献
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报道了用3-甲酰基色酮、5,5-二甲基-1,3-环己二酮、乙酰乙酸乙酯与醋酸铵一步法合成4-(色酮-3-基)-3-乙氧羰基-1,4,5,6,7,8-六氢-5-氧代-2,7,7-三甲基喹啉类化合物, 对其结构进行了表征, 并分析了代表性化合物2f的晶体结构. 2f晶体属于单斜晶系, P2/c空间群, 所得晶胞参数为: a=2.0255(4) nm, b=0.9132(2) nm, c=1.4066(3) nm, β=121.60(3)°, V=2.2159(8) nm3, Z=4, Dc=1.335 g/cm3, μ=0.209 mm-1, F(000)=736, R1=0.0556, wR2=0.1248. 相似文献
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合成了一系列具有刚性结构的推拉型1,2,3,4-四氢喹啉-4-酮衍生物: 1-苄基-1,2,3,4-四氢喹啉-4-酮(BTHQ)、2-(1,2,3,4-四氢喹啉-4-叶立德)丙二腈(THQM)、1,6-二羰基久洛尼定(DOJ)和1,6-二(二氰甲烯基叶立德)久洛尼定(BDCJ).测定了其吸收光谱、单光子荧光光谱和双光子上转换荧光光谱. 这类化合物的单双光子荧光参数都存在着很强的、规则的溶剂效应, 表明分子激发态可能存在较大的极性. 它们的二氯甲烷溶液在800 nm飞秒激光(150 fs)照射下, 能够发射出很强的双光子上转换荧光. 采用非线性透过率法测得四个化合物的双光子吸收截面在0.83~23.95×10-50 cm48226;s8226;photon-1之间. 这类化合物的激发态存在有效的分子内电荷转移, 对双光子吸收和双光子荧光发射有较大贡献. 相似文献
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本文报道了以(E)-1-(2-对甲苯磺酰胺基)-3-芳基丙-2-烯-1-酮(1)为底物与N-硫代丁二酰亚胺(2)通过亲电环化反应合成2-芳基-3-硫代-2,3-二氢喹啉-4(1H)-酮类化合物。以三氟化硼乙醚为催化剂(20 mol %),1,2-二氯乙烷为溶剂,反应温度为60 oC,可以60-92%的收率得到一系列2-芳基-3-硫代-4(1H)-喹啉酮衍生物,化合物3a-k均未见文献报道,其结构均经过1H NMR, 13C NMR以及高分辨质谱进行确定。 相似文献
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以豆腐果苷为原料, 与盐酸羟胺缩合反应生成4-β-D-吡喃阿洛糖苷-苯甲醛肟(2), 2与次氯酸叔丁酯发生取代反应生成4-β-D-吡喃阿洛糖苷-α-氯苯甲醛肟(3); 再将3与Schiff碱通过1,3-偶极环加成生成一系列3-(4-β-D-吡喃阿洛糖苷-苯基)-4-芳基-5-芳基-1,2,4-噁二唑啉(5a~5h). 3和 5a~5h共9个化合物均未见文献报道, 其结构经1H NMR, IR和MS (HRMS)加以确认, 并对5a~5h进行了药理活性筛选. 结果表明, 部分化合物具有良好的镇静活性. 其中, 化合物5g (200, 100 mg•kg-1)和5h (200, 100 mg•kg-1)与豆腐果苷相比较具有更强的活性. 相似文献
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V. A. Tartakovsky I. E. Filatov A. M. Churakov S. L. Ioffe Yu. A. Strelenko V. S. Kuz’min G. L. Rusinov K. I. Pashkevich 《Russian Chemical Bulletin》2004,53(11):2577-2583
Treatment of 2- and 4-amino-3-(tert-butyl-NNO-azoxy)pyridines with nitrating agents (N2O5or NO2BF4) afforded the first representatives of pyridoannelated 1,2,3,4-tetrazine di-N-oxides, viz., pyrido[2,3-e][1,2,3,4]tetrazine 1,3-dioxide (9), 7-nitropyrido[2,3-e][1,2,3,4]tetrazine 1,3-dioxide (10), and pyrido[3,4-e][1,2,3,4]tetrazine 2,4-dioxide (11). These compounds were studied by 1H, 13C, and 14N NMR spectroscopy. The 1:1 complex of compound 10 with benzene was studied by X-ray diffraction analysis.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2471–2477, November, 2004. 相似文献
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在碳酸钾存在下, 以丙酮或乙腈为溶剂, 3-芳基吡唑-5-羧酸乙酯与芳甲基氯发生亲核取代反应, 以较好收率得到1-芳甲基-3-芳基吡唑-5-羧酸乙酯衍生物. 取代基以及溶剂对反应收率有较大影响. 1H NMR, 13C NMR, IR和MS表征了化合物的结构. 通过X射线衍射分析测定了化合物3c的晶体结构. 所得化合物3a~3d在5~20 μmol•L-1浓度范围对血管内皮细胞(HUVEC)凋亡具有促进活性, 其效果具有浓度依赖性. 相似文献
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Yoshihisa Kurasawa Muneto Muramatsu Kaoru Yamazaki Setsuko Tajima Yoshihisa Okamoto Atsushi Takada 《Journal of heterocyclic chemistry》1986,23(5):1379-1382
Novel 1-aryl-1H- and 1-aryl-3-heteroaryl-1H-pyrazolo[3,4-b]quinoxalines (flavazoles) 9a-c, 12, 13 were synthesized from 3-methyl-2-oxo-1,2-dihydroquinoxaline 5 and the 3-triazolylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline 6, respectively, via a facile hydrazone synthesis using aryl diazonium salts. Some of the above flavazoles and their related compounds exhibited the antifungal activity in some extent. The above results are described. 相似文献
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Hai Shi Fang-Ming Liu Song-Wei Shen 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):263-270
Abstract A series of novel 3-aryl-5-(2-aryl-1,2,3-triazol-4-yl)-1-(4-aryl-2-thiazoyl)-pyrazolines 6a–6r were synthesized using 2-aryl-4-formyl-1,2,3-triazoles 1a,b as the starting materials. Thus, reacting 1a,b with 1-arylethanones 2a–2c gave 1-aryl-3-(2-aryl-1,2,3-triazol-4-yl)-2-propen-1-ones 3a–3f. The reaction of the latter with thiosemicarbazide afforded 3-aryl-5-(2-aryl-1,2,3-triazol-4-yl)-1-thiocarbamoyl-pyrazolines 4a–4f, which condensed with 2-bromo-1-arylethanones 5a–5c to afford the target compounds 6a–6r. The chemical structures of the compounds were verified by means of their IR, 1H NMR, ESI-MS spectroscopic data, and elemental analysis. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT 相似文献
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Kozlov N. G. Basalaeva L. I. Firgang S. I. Shashkov A. S. 《Russian Journal of Organic Chemistry》2004,40(4):518-524
Cascade heterocyclization of 3(4)-methylcyclohexanone, substituted benzaldehyde, and 2-naphthyl-amine in a polar solvent in the presence of hydrochloric acid afforded the corresponding 5-aryl-2(3)-methyl-1,2,3,4-tetrahydrobenzo[a]phenanthridines and 12-aryl-9(10)-methyl-8,9,10,11-tetrahydrobenz[a]acridines 相似文献
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New methods for the synthesis of (E)-3-halo-2-styryl-4H-chromen-4-ones were established. The reaction of these compounds with hydrazine hydrate afforded new and unexpected 3(5)-aryl-5(3)-[2-(2-hydroxyphenyl)-2-hydrazonoethyl]-1H-pyrazoles, which upon acid hydrolysis gave 3(5)-aryl-5(3)-[2-(2-hydroxyphenyl)-2-oxoethyl]-1H-pyrazoles. The reaction mechanisms for these transformations, involving 1,6- followed by 1,4-conjugate additions, are discussed and the structures of all new compounds were established by NMR studies. 相似文献