基于制药工程专业认证的化工原理课程体系创新与建设*

归纳并总结了制药工程专业化工原理教学过程存在的问题,并基于本科国家教学质量标准、工程教育专业认证通用标准及补充标准,对制药工程专业化工原理理论课课程体系进行重新构建。在此基础上,提出多种导课方法结合、加强对复杂工程问题的分析与解决能力、强化讲解各单元操作之间的共性与本质、课程考核标准等改革措施,并对改革效果进行分析。改革后的化工原理课程提高了学生解决复杂制药工程问题的能力,课程目标达成情况明显改善,取得了良好的教学效果。     

应用化学专业实验教学综合改革探索

简要介绍正在实施的新的应用化学专业实验课程体系及正在开展的“面向 2 1世纪化学实验课程教学综合改革与研究”项目的内容、进展及初步效果     

双一流背景下有机化学精准教学的探究实践*

有机化学课程是本校化学师范和高分子材料与工程2个国家级一流本科专业以及应用化学、制药工程等专业基础必修课程。由于化学师范和非师范专业的培养目标不同,有机化学的精准教学方面也有所差异。主要从理论教学、实验教学和多媒体教学等3个方面对化学师范专业和非师范专业有机化学差异化精准教学进行了探究实践,化学师范专业有机化学的精准教学侧重于培养学生的教学能力,非师范专业有机化学的精准教学侧重于培养学生的应用能力。     

药学专业综合化学科研训练课程体系的建设与实践

针对药学专业本科生在课内教学中进行科研训练存在的相关问题,依托综合化学实验课程,从课程设置、训练目标、训练内容和训练指导编写等几个方面,阐述了药学专业综合化学科研训练课程体系的建设方法和实践成效。     

基于OBE和EHS理念的制药过程安全与环保课程体系建设

“制药过程安全与环保”为制药工程专业本科生必修核心课程，但其课程体系不完善，基于OBE和EHS理念，从课程目标、课程内容、课程思政、教材、教学方法、课程考核与评价方法等方面对该课程进行了建设和完善，取得了一些创新性成果与经验，制定了教学目标，创新性地设置了课程内容，开展了课程思政，主编了教材，提出了适宜的教学方法，建立了课程考核与评价方法，可以为全国其他高等院校类似课程的教学与建设提供有益的借鉴。     

以技术要素为主线重组实验教学体系

复旦大学化学系一贯重视实验教学。在实验课程改革方面 ,率先在国内建立仪器分析实验基础课 ,并对物理化学实验内容进行了大幅度改革 ,编写了教材 ,在国内有一定影响。 2 0世纪 80年代末 ,又在对国内外著名大学课程教学体系进行广泛比较研究的基础上 ,进行课程体系改革。到 2 0世纪 90年代中期提出了“以数学和自然科学为基础 ,化学原理为先导 ,有机物和无机物为对象 ,定量分析和结构表征并重”的课程体系 ,并投入教学实践 ,取得了良好效果[1] 。在进行理论课程体系改革的同时 ,我们也在积极进行实验教学课程体系改革的探索和准备。如在 1 9…     

能源与环境系统工程专业工程化学课程的教学改革与实践

工程化学课程是本校非化学化工专业(能源与环境系统工程专业)的一门学科基础课程。该课程的目的是锻炼学生的化学思维能力,通过学习工程应用中的化学理论,提高学生运用化学知识解决实际问题的能力。本文阐述了本校工程化学课程的教学理念和授课情况,对教学内容和方法进行了深入的改革与实践,详细介绍了课程建设、课堂教学、课下反馈与评价、科研相辅、教学工作的反思与总结,进一步阐述了教学环节的教育探索与实践总结,使工程化学课程的教学质量得到了提高。     

本科化学专业实验教学模式的改革与实践

以培养学生的创新思维和实践能力为目标,对本科化学专业实验课程体系与内容进行了全面改革。将化学学科中传统的无机化学实验、有机化学实验、分析化学实验、物理化学实验4大实验的内容设计优化成基础实验、综合设计实验、研究创新实验3个实验模块,搭建了基础型、提高型、创新型3个能力训练层次和1条毕业设计/专业实习能力训练主线,构建了具有地方本科院校特色的化学专业 “331”实验课程新体系,实现了课程结构的模块化,实验内容的层次化和教学科研的一体化。实践证明,通过改革与实践激发了学生的学习兴趣和主动性,动手能力、分析问题和解决问题的能力都有一定程度的提高。     

《高分子化学》课程在土建类本科院校的教学改革初探

《高分子化学》是高分子材料与工程专业四大专业基础课之一,作为该专业学生接触的第一门专业基础课,内容涵盖了高分子的基本概念、聚合方法、聚合反应类型和机理,是进一步学习其他专业课程的基础。本文根据高分子化学课程在土建类工科院校的现状,结合近年来高分子化学课程的教学实践与探索,从增加教学中建筑材料切入点、探索适应工科学生的互动教学模式、注重高分子化学实验的互补作用、与行业实际相结合等角度出发,改进教学方法,提高教学质量,培养学生的创新能力和专业自信心,提出了适应高分子材料与工程专业、具有土建类本科院校特色的《高分子化学》课程教学改革的一些建议。     

独立学院制药工程专业化工原理实验教学内容改革研究

提出独立学院制药工程专业化工原理实验课程的教学目的和确定其内容的原则,并对化工原理实验的教学内容和建设创新型化工原理实验室进行了探讨。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.