制药工程专业化学课程改革的探索与实践

化学课程是制药工程专业的必修课程,教学中存在部分理论内容交叉重叠、实验课程相互独立、内容多学时少、教学模式与教学评价体系陈旧等问题。介绍了临沂大学制药工程专业在化学课程改革方面的一些探索与实践,包括对理论课程体系和实验课程体系进行整合和优化、开设化学综合性实验和创新性实验、改进教学方法和进行创新课堂建设、推进化学课程考试和考核改革等,以期为制药工程专业化学课程教学改革提供一些思路和借鉴。     

国外仪器分析课程内容与教学方法的研究

针对国内仪器分析教学中存在的教材相对陈旧、课程内容未能体现学科的最新发展、缺乏有效的考核评价方式和标准等问题,本文收集了国外部分代表性高校化学专业与仪器分析教学相关的现使用教材和课程体系,通过梳理和比较分析,归纳出其特点,希望能对今后仪器分析课程建设、教学内容完善以及考核评价标准的改革提供有益的借鉴。     

化学课程与教学论课程思政实践

课程思政是化学课程与教学论课程落实立德树人的重要内容之一。基于化学课程与教学论课程理论性、实践性、师范性强等特点,从设计课程目标、挖掘课程思政元素、建设课程思政教学案例库、提升教师课程思政能力等4个方面探索了课程思政的实践,从学生评价、课程成绩考核等2个方面探究了课程思政的教学成果评价。以期为化学(师范)专业的课程思政体系建设提供参考。     

发展中的化学科学课程的全方位构建

发展中的化学科学课程是大类生化地专业学生的通识平台课程.根据发展中的化学科学课程特点和教学内容,在教学目标、课程内容体系构建、课程建设特色、教学方法以及考核评价体系等方面进行了探讨.     

课程思政背景下大学基础有机化学实验教学探索与实践*

从大学基础有机化学实验“课程思政”建设背景出发,讨论了课程思政的育人目标、实验教学中如何融入课程思政、课程思政的建设策略以及课程思政实施与考核评价方式等方面。结合实验教学过程探讨了基础有机化学实验教学中融入课程思政的教学探索和实践。     

化学专业概论教学中的课程思政探索与实践*——以华中科技大学“一院一品”化学专业概论课为例

课程思政是高校落实立德树人根本任务的重要举措,是完善“三全育人”的重要抓手。化学是我国科学研究的重要基础,对提升原始创新能力具有重要意义。化学专业教学中融入思想政治教育的前提是建设好一门课程。针对当前专业课教学中存在的课程思政体系不完善、思政元素与专业课程融合程度低、教师思政教学水平有待提高等问题,以华中科技大学化学与化工学院专业概论课为试点,完善课程设计与教学方法,探索化学专业教学中的课程思政建设。通过剖析化学课程思政的意义与难点,构建专业概论课实施方案,形成一套行之有效的化学课程思政建设体系。     

化工原理课程思政教学改革与实践

介绍了化工原理课程思政的育人目标,据此构建课程内容与育人元素的支撑矩阵;融入绿色工程理念,确定课程对绿色工程十二项原则指标点的支撑;深度融合信息技术,基于原有慕课建设专门的课程思政慕课;以精馏章节为例,分享化工原理课程思政教学案例设计思路和方案。同时,对学生测评和学习成果、育人点、重要性及切入自然性进行调研评价,说明通过课程思政教学实践,在潜移默化中培养学生树立正确的世界观、人生观和价值观。为化工类专业课程思政教学提供参考和借鉴。     

基于“工程实践能力培养”的《化学工艺学》课程建设与教学实践

针对工程实践能力的培养,以《化学工艺学》课程建设为切入点,对教学内容与教材建设、教学模式与教学方法、教学队伍、考核内容及考核方法等方面的改革进行了理论和实践探索,取得了一定成效。编撰出版了工程特色突出、注重工程实践能力培养的普通高等教育"十二五"规划教材《化学工艺学》,创建并实践了集先进性、创新性和实用性于一体的"三型案例并用"教学法,探索实践了"将理论教学与毕业实习、化工仿真实训相结合"的能够强化工程实践能力培养的新型教学模式。     

面向行业职业需求的双环增长式应用型课程教学改革——安全工程专业化工安全学课程

针对应用型课程存在的人才培养与企业需求不衔接的教学痛点,基于“项目驱动,成果导向,能力提升,价值引领”的课程建设理念,探索形成了面向行业职业需求的双环增长式应用型课程教学模式,即基于职业需求问题的课程体系建设改进环和基于项目驱动的课堂教学改进环。通过建立基于职业需求的三位一体教学目标,以能力本位重构课程内容,突出职业素养和人文素养,多维度融入思政元素,基于“5W1H”项目分析逻辑构建项目驱动三阶段混合式十步教学,开展沉浸式、交互式仿真实场景教学和突出职业能力目标达成为导向的课程考核评价,切实提高了学生的应用型能力。     

化学类专业课程思政要素与途径的探索和实践

探讨了化学类专业课程思政要素、教学方法和途径,提出了“六维度、四构建”思政教学策略。从化学中的哲学思想、化学的价值观、化学科学精神、化学思维方法、化学伦理、化学文化“六维度”确定化学类专业课程思政要素;以教学目标创建为基础、教学内容和教学资源重构为重点、教学方法构建为关键、成绩评定体系建立为保障的“四构建”系统设计课程思政的教学方法和途径。基于“六维度、四构建”课程思政策略,对无机及分析化学课程进行了教学实践。实施结果表明,这些策略能有效提高课程育人的针对性和有效性,为高校同类课程思政建设提供一个可借鉴的思路和模式。     

物理化学在药剂学领域的应用

从物理化学在药剂学领域包括药物新剂型设计、药用辅料选择和制剂干燥成型技术3个方面的应用情况,着重介绍物理化学的基础知识和基本理论在药剂学领域的指导作用,以期加强物理化学教学内容与药剂学专业知识的融合,激发药剂学专业大学生学习物理化学的兴趣和提高课堂教学质量。     

High performance liquid chromatographic analysis of dehydroepiandrosterone and its pharmaceutical tablet formulation

A rapid, sensitive and stability indicating high performance liquid chromatographic method was developed and validated for the analysis of dehydroepiandrosterone (DHEA) in pharmaceutical tablet formulation. The analysis was done on a Supelcosil C(18) column (25 cm x 4.6 mm i.d., 5 microm). The mobile phase consisted of methanol:sodium acetate buffer solution (5 g/L):acetic acid (500 mL/L), 57:42:1, v/v/v, adjusted to pH 5 at a flow rate of 1 mL/min. Detection was carried out at a wavelength of 258 nm. The polynomial regression data for the calibration curve showed good linear relationship in the concentration range of 0.2-1 mg/mL with r = 0.9996. The method was validated for precision, accuracy and recovery. The limit of detection was found to be 50 ng/ microL. The method was applied for the analysis of DHEA in its pharmaceutical tablet formulation. The effects of different buffers and alcohols on the retention of DHEA were studied and the role of acetic acid as an organic phase modifier was also investigated.     

Thermal and dissolution kinetics of ampicillin drug and capsules

This work aims to compare the thermal decomposition and dissolution kinetics of ampicillin drug and products A, B and C. The thermal decomposition reaction rate constants (kT) were determined by isothermal thermogravimetric method using the classical Arrhenius equations. The dissolution profiles were obtained using USP 23 method and rate constants (kD) were determined by Kitazawa equation. The results showed correlation between kT and kD can be used in the study of preformulation of drugs and also as a parameter in the studies of pharmaceutical equivalence. This revised version was published online in July 2006 with corrections to the Cover Date.     

制药工程专业药物分析实践教学模式的探索

针对目前制药工程专业药物分析实践教学中存在的缺乏工科性、与生产联系少等问题,通过实践教学改革和查阅文献,从校内实验、校内实训和校外实习3个方面对药物分析的实践教学模式进行了探索,强调该课程的综合性和工科特色,增强了学生实践能力。     

制药专业药物合成实践课程项目化教学探索

根据制药专业药物合成类课程特点,详述了以美国IUPUI大学国际化教科研项目“分散式药物发现”计划为蓝本的“药物的合成设计与制备实验”课程项目化教学改革在我校制药类专业实践教学中的应用。通过对该课程进行连续2年的跟踪探索,发现这种教学模式不但可以使学生充分了解当今国际药物开发的前沿技术,开阔了眼界,也培养了学生主动学习和思考的动力与能力,提高了他们的创新意识、科学精神及团队协作意识,为今后的职业发展打下坚实基础。     

DSC studies on the polymorphism and pseudopolymorphism of pharmaceutical substances

A complex system including thermoanalytical methods, infrared spectroscopy and X-ray powder diffraction for studying physico-chemical behaviour of binary mixtures is described. This system has been tested by investigating binary mixtures of amphetamine hydrochloride salts.These studies have proved that among the selected compounds the primary and secondary amine hydrochloride salts exhibit conglomerate forming tendency, while the tertiary amine hydrochloride salts form molecular compounds (racemates). For thep-fluoro amphetamine hydrochloride the existence of two polymorphic modifications has been detected.The authors are grateful to D. Kozma (Department of Organic Chemical Technology) for the thermoanalytical data of compound III, to Prof. E. Fogassy for the fruitful discussion.     

Thermal characterization of polyethylene glycols applied in the pharmaceutical technology using differential scanning calorimetry and hot stage microscopy

In the present study, the effect of the molecular weight and thermal treatments on commercial polyethylene glycols (PEG) samples used in the pharmaceutical processing technology, has been analyzed using DSC and HSM. The molecular weight of these polymers range from 1500 to 200000. Thermal investigations on the melting behavior of original PEG samples (as received from the manufacturer) showed only one single melting DSC endotherm effect before 373 K. This fact was associated to the presence of only one type of polymeric chain. Using standard conditions, PEG samples were solidified from the melt at 373 K, either by flash cooling (using liquid nitrogen and an ice bath) and by slow cooling, soaked and by slow cooling at room temperature. They were further studied by DSC. It was found that after cooling, PEG with molecular weight 1500 and 15000 showed DSC thermograms with a single endothermic peak. However, thermograms for PEG 4000 and 6000 produced a splitted melting endotherm. This fact was attributed to the presence of two types of chains, that are the folded and extended chains.Ageing time influences also the shape of the DSC endothermal effects. It was concluded that the endotherms obtained after heating these PEG indicate that the thermal history determine the structure (extended or folded chain type forms) and the degree of crystallinity, as evidenced by changes in heat of fusion values, melting points and structures after crystallization. The relationships between melting enthalpies and melting points, as deduced from DSC diagrams, with molecular weight of the polymers are also presented.     

Fluorimetric Determination of Gatifloxacin in Aqueous,Pure and Pharmaceutical Formulations

Abstract

A spectrofluorimetric method was developed for the determination of gatifloxacin. The emission peak for gatifloxacin was recorded at 495 nm upon excitation at 291 nm. The fluorescence process was pH dependent. The dynamic range for the method was 16–80 ng ml^?1with detection limit of 3.97 ng ml^?1. A linear relationship between the fluorescence intensity and the concentration of gatifloxacin solution was obtained with r ² of 0.9968. The method has successfully applied to the determination of gatifloxacin in pure, authentic and aqueous samples.     

Thermal Stability of Prednisone Drug and Tablets

TG and DSC data were used to determine the thermal parameters of prednisone drug and tablets. Two formulations of prednisone 20 mg were analysed in the form of tablets. The TG curves of prednisone drug and tablets A and B displayed six, eight and seven thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between prednisone drug and the excipients of tablets A and B, suggested by alterations in the melting temperature of prednisone. The analysis revealed that prednisone drug is more stable than tablets A and B. This revised version was published online in July 2006 with corrections to the Cover Date.