共查询到17条相似文献,搜索用时 218 毫秒
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以对甲基苯胺为原料,经过重氮化反应生成对甲基叠氮苯(1).在强碱性条件下,1分别与氰基乙酸乙酯、氰基乙酰胺反应,制得中间体1-对甲苯基-5-氨基-1,2,3-三唑甲酸乙酯(2)和1-对甲苯基-5-氨基-1,2,3-三唑甲酰胺(5);中间体2经水解生成1-对甲苯基-5-氨基-1,2,3-三唑甲酸(3),进而在弱酸性条件下与取代苯甲醛反应得到6个未见文献报道的目标化合物1-对甲苯基-5-取代苯基亚胺基-1,2,3-三唑甲酸(4a~4f),5与取代苯甲醛反应得到6个未见文献报道的目标化合物1-对甲苯基-5-取代苯基亚胺基-1,2,3-三唑甲酰胺(6a~6f),化合物的结构均经IR,1H NMR,13C NMR确证.初步生物测试表明,12个化合物均表现出良好的抑菌活性,其中化合物4d~4f和6d~6f对金黄色葡萄球菌、白色念球菌的最小抑菌浓度(MIC)值为2~8μg/mL,抗菌效果优于氟康唑和三氯生. 相似文献
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采用一维(1D)和二维(2D)核磁共振(NMR)技术对一种抗癫痫活性的化合物1-(2,6-二氟苯甲基)-N-甲基-1H-1,2,3-三唑-4甲酰胺的1H和13C NMR信号进行了归属。 相似文献
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在微波作用的无溶剂条件下,由4β-叠鬼臼毒素与炔烃反应,合成了8个含有 1,2,3-三唑的鬼臼毒素衍生物,并用IR, ~1H NMR, MS确定了这些化合物的结构。 该反应操作简单,产率较高,副产物少,同时具有原子经济性。 相似文献
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以间苯二酚为原料,经5步反应制得中间体4,4′-[4,6-双(己氧基)-1,3亚苯基]双{1-[4-(叠氮甲基)苯基]-1H-1,2,3-三氮唑}(6); 6与1,5-二乙炔基-1,4-二(己氧基)苯在高度稀释的条件下经Click反应环合制得1,2,3-三唑环蕃(7); 7与三甲基氧鎓四氟硼酸盐反应合成了全甲基化的新型1,2,3-三唑鎓环蕃,其结构经1H NMR, 13C NMR和HR-ESI-MS表征。 相似文献
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《结构化学》2018,(12)
In this work, 1,4-bis(4-phenyl-1,2,3-triazole)benzene, 1,3-bis(4-phenyl-1,2,3-triazole)propane, bis(1-phenyl-1,2,3-triazole)-methylphenylsilane, and 1-ally-4-phenyl-1,2,3-triazole have been designed and synthesized via Click reaction. Fourier transform infrared spectroscopy(FT-IR) and nuclear magnetic resonance spectroscopy(NMR) were used to confirm the compounds' structures. The effect of silicon atom on the optical properties has also been studied. The UV-vis absorption wavelength of silicon-containing compound is about ca. 10 nm red-shifted when compared with that of other three compounds. The fluorescence emission bands of the compounds in CHCl_3 solutions were observed around ca. 440 nm. And the luminescent coordination compound, namely [AgL1?NO_3?3H_2O]n, based on the ligand 1-allyl-4-phenyl-1,2,3-triazole has been prepared. In addition, this complex exhibits a 1 D chain structure. The crystal structure has been determined by single-crystal X-ray diffraction, and the optical properties have been investigated by fluorescence spectrum. In summary, our work may provide new materials with luminescent property which is potentially useful in material fields. 相似文献
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Dominique R. Wozniak Benjamin Salfer Dr. Matthias Zeller Dr. Edward F. C. Byrd Prof. Davin G. Piercey 《ChemistryOpen》2020,9(8):806-811
Energetic N-amino-C-nitro compounds 1-amino-4-nitro-1,2,3-triazole and 2-amino-4-nitro-1,2,3-triazole are characterized for the first time as energetic materials. These compounds were characterized chemically by nuclear magnetic resonance (NMR), Infrared spectroscopy and X-ray crystallography. Compounds were also characterized energetically by differential scanning calorimetry (DSC), impact, and friction and found to possess sensitivities and performances classifying them as primary explosives with PETN-like performance. 相似文献
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将邻羟苯基引入1,2,3-三唑结构中, 设计合成了10个1-(4-取代苯基)-4-苯基-5-取代-1,2,3-三唑类衍生物. 首先, 以对位取代的芳胺为原料, 经重氮化、叠氮化、闭环和缩合反应制得1-(4-取代苯基)-4-苯基-5-水杨醛亚胺-1,2,3-三唑类衍生物(3a~3e), 再用硼氢化钠还原制得1-(4-取代苯基)-4-苯基-5-(2-羟基苄基)氨基-1,2,3-三唑类衍生物(4a~4e). 目标化合物的结构经核磁、IR及元素分析确认. 抑菌活性测试表明, 当质量浓度为0.1 mg/L时, 除化合物3e和4e外, 所有化合物对白色念球菌的抑菌率均达95%以上, 对大肠杆菌的抑菌率达85%以上, 具有强抑菌活性, 表明该类化合物在抗菌药物开发方面有重要应用价值. 相似文献
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以(4,4′-二氟苯)甲酮、盐酸羟胺、苄溴及溴丙炔为原料,应用5 mol%的CuI为催化剂,DMF-H 2O(1∶1)为溶剂,在70℃反应4h以23~81%的收率制得了9个含有(4,4′-二氟苯)甲酮肟醚官能团的1,2,3-三氮唑衍生物5(a~i)。合成的9个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析对其结构进行确证。经体外抗菌活性测试表明有4个化合物对时对所测试的大肠杆菌具有明显的抑制活性,其MIC为32ug·mL-1。 相似文献
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T. I. Vakul’skaya I. A. Titova L. I. Larina O. N. Verkhozina G. V. Dolgushin V. A. Lopyrev 《Chemistry of Heterocyclic Compounds》2006,42(11):1427-1434
The vicarious nucleophilic substitution of hydrogen in symmetrical and vicinal nitrotriazoles by 1,1,1-trimethylhydrazinium
iodide in t-BuOK/DMSO was studied by ESR. In the ESR monitoring of the reactions the primary radical-anions of 4-nitro-2-phenyl-1,2,3-triazole
and 1-methyl-3-nitro-1,2,4-triazole were detected and characterized. It was shown by NMR that the amination of 4-nitro-2-phenyl-1,2,3-triazole
takes place exclusively in the triazole ring with the formation of 5-amino-4-nitro-2-phenyl-1,2,3-triazole. 1-Methyl-3-nitro-1,2,4-triazole,
like 3-nitro-1,2,4-triazole, does not form amination products. A possible mechanism for the vicarious C-amination of nitrotriazoles
and the formation of the radical-anions of the substrates is discussed.
Dedicated to Academician M. G. Voronkov on his 85th birthday.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1662–1670, November, 2006. 相似文献
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Ichino T Andrews DH Rathbone GJ Misaizu F Calvi RM Wren SW Kato S Bierbaum VM Lineberger WC 《The journal of physical chemistry. B》2008,112(2):545-557
A combination of experimental methods, photoelectron-imaging spectroscopy, flowing afterglow-photoelectron spectroscopy and the flowing afterglow-selected ion flow tube technique, and electronic structure calculations at the B3LYP/6-311++G(d,p) level of density functional theory (DFT) have been employed to study the mechanism of the reaction of the hydroxide ion (HO-) with 1H-1,2,3-triazole. Four different product ion species have been identified experimentally, and the DFT calculations suggest that deprotonation by HO- at all sites of the triazole takes place to yield these products. Deprotonation of 1H-1,2,3-triazole at the N1-H site gives the major product ion, the 1,2,3-triazolide ion. The 335 nm photoelectron-imaging spectrum of the ion has been measured. The electron affinity (EA) of the 1,2,3-triazolyl radical has been determined to be 3.447 +/- 0.004 eV. This EA and the gas-phase acidity of 2H-1,2,3-triazole are combined in a negative ion thermochemical cycle to determine the N-H bond dissociation energy of 2H-1,2,3-triazole to be 112.2 +/- 0.6 kcal mol-1. The 363.8 nm photoelectron spectroscopic measurements have identified the other three product ions. Deprotonation of 1H-1,2,3-triazole at the C5 position initiates fragmentation of the ring structure to yield a minor product, the ketenimine anion. Another minor product, the iminodiazomethyl anion, is generated by deprotonation of 1H-1,2,3-triazole at the C4 position, followed by N1-N2 bond fission. Formation of the other minor product, the 2H-1,2,3-triazol-4-ide ion, can be rationalized by initial deprotonation of 1H-1,2,3-triazole at the N1-H site and subsequent proton exchanges within the ion-molecule complex. The EA of the 2H-1,2,3-triazol-4-yl radical is 1.865 +/- 0.004 eV. 相似文献