| 1,4-二取代-1,2,3-三唑衍生物的合成 |
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| 引用本文： | 于金兰,武钦佩,张青山,周智明.1,4-二取代-1,2,3-三唑衍生物的合成[J].合成化学,2010,18(1). |
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| 作者姓名： | 于金兰 武钦佩 张青山 周智明 |
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| 作者单位： | 北京理工大学,化工与环境学院,北京,100081 |
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| 基金项目： | 中国科技部863计划资助项目 |
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| 摘 要： | 在超声波辐射下,端基炔与叠氮基(3,3-二甲基-2,4-二氧戊环基)甲烷通过1,3-偶极环加成合成了1-(3,3-二甲基-2,4-二氧戊环基甲基)-4-芳基-1,2,3-三唑(5);5在酸性条件下脱保护得1-(2,3-二羟基丙基)-4-芳基-1,2,3-三唑,其结构经1H NMR,13C NMR,MS和元素分析表征。
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| 关 键 词： | 1 2 3-三唑 叠氮基甲烷 端基炔 1 3-偶极环加成 合成 |
Synthesis of 1,4-Dissubstituted-1,2,3-triazole Derivatives |
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| YU Jin-lan,WU Qin-pei,ZHANG Qing-shan,ZHOU Zhi-ming.Synthesis of 1,4-Dissubstituted-1,2,3-triazole Derivatives[J].Chinese Journal of Synthetic Chemistry,2010,18(1). |
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| Authors: | YU Jin-lan WU Qin-pei ZHANG Qing-shan ZHOU Zhi-ming |
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| Abstract: | 1-(3,3-dimethyl-2,4-dioxolaneyl-methyl)-4-aryl -1,2,3-triazole(5) was synthesized by 1,3-dipolar cycloaddition of 3,3-dimethyl-2,4-dioxolaneyl-methyl azide and terminal alkyne under ultrasound irradiation for 20 min.The hydroxyl protection of 5 was removed in acidic solution to obtain 1-(2,3-dihydroxylpropyl)-4-aryl -1,2,3-triazole(6).The structures were characterized by ~1H NMR,~(13)C NMR,MS and elemental analysis. |
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| Keywords: | 1 2 3-triazole methyl azide terminal alkyne 1 3-dipolar cycloaddition synthesis |
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