手性炔丙醇的不对称催化合成研究进展

手性炔丙醇是一种重要中间体化合物,作为合成多种光学活性化合物的重要合成前体受到学者们广泛关注。目前通过酮的不对称催化反应合成手性炔丙醇的研究开发具有极大发展前景,因此本文围绕酮类化合物的不对称催化反应来进行综述,结合相关反应最新研究进展,全面总结并分类了不对称催化还原、催化不对称加成等反应类型,介绍了合成不同结构手性炔丙醇的新思路,并对酮的不对称催化反应在未来能成为工业化重要生产途径作出展望。     

HIRFL人身安全联锁系统的设计与实现

兰州重离子加速器(简称HIRFL),是我国规模最大、加速离子种类最多、能量最高的重离子研究装置,可提供单核子能量达GeV量级的重离子束。HIRFL运行时,束流会在加速器隧道内产生辐射,需要建立一套人身安全联锁系统来保障人员的辐射安全。HIRFL人身安全联锁系统遵循分区联锁、硬件最可靠、失效保护、冗余及独立性、自锁等设计原则,选用了可靠性高的冗余PLC作为核心控制器,并使用了安全性高的联锁部件。本工作的完成保障了HIRFL工作人员的辐射安全,也为同类型加速器装置的人身安全联锁系统设计提供了参考。     

HIAF高能辐照终端感生放射性

本工作是基于蒙特卡罗模拟软件FLUKA对高能强流重离子加速器（HIAF）高能辐照终端感生放射性进行初步研究。该终端可运行质子最高能量为9.3 GeV,最大流强是1.45×1012 pps（particle per second）。研究内容包括:（1）预测高能辐照终端内活化物质的放射性活度特性;（2）预测不同冷却时间高能辐照终端内残余剂量率分布。研究结果表明,HIAF正常运行时高能辐照终端内的感生放射性主要受束流垃圾桶活化产生的放射性核素影响。当加速器连续运行100天冷却4小时,垃圾桶表面残余剂量率为2.375 mSv·h-1。终端内空气中13N和15O动态饱和比浓度大于其对应的导出空气浓度。冷却水中13N和15O的活度大于对应的ALI_min。该研究是HIAF辐射防护基础研究以及加速器环境影响评价的一项重要内容。The Monte Carlo code FLUKA was used to predict the induced radioactivity of high-energy irradiation terminal of HIAF. The maximum energy of proton is 9.3 GeV, and the maximum current is 1.45×1012 pps (particle per second). In this study we were to predict:(1) the activity properties of activated substances in the experimental terminal; (2) the residual dose rate distribution in the experimental terminal at different cooling time. The results indicate that the induced radioactivity in the high energy irradiation terminal of the HIAF is mainly affected by the radionuclide induced in the beam dump. The residual dose rate on the surface of the beam dump is 2.375 mSv·h-1, after 100 d irradiation and 4 h cooling. The dynamic saturation ratio of 13N and 15O induced in the air inside the terminal is higher than its corresponding derived air concentration. The activity of 13 N and15O induced in cooling water is higher than its ALI_min. This study is a part of radiation protection basic research and environmental impact assessment for HIAF.     

HIAF BRing及高能外靶实验终端的辐射屏蔽设计

强流重离子加速器（HIAF）是中国科学院近代物理研究所自主研制的一台高能强流重离子加速器,它可以实现p到U的全离子加速。为了保证HIAF运行时的辐射安全,针对该装置的增强器（BRing）及高能外靶实验终端,利用蒙特卡洛程序FLUKA及外推法计算得到了加速p,C及U三种离子时所需的辐射屏蔽。结果表明,加速质子时所需屏蔽厚度最大,并以此为依据给出了全地下结构的屏蔽设计。在此基础上,提出了一种估算高能质子/重离子加速器束流均匀损失时横向屏蔽厚度的方法。结果显示,估算结果与FLUKA计算结果符合较好,验证了该方法的有效性和准确性。High Intensity heavy-ion Accelerator Facility (HIAF) is designed by the Institute of Modern Physics, Chinese Academy of Sciences, which can accelerate particles from proton up to uranium. To guarantee the radiation safety of HIAF during operation, the FLUKA code and extrapolation method were adopted to calculate the shielding thickness. The calculations were based on proton, carbon and uranium particles when losing on the Booster Ring (BRing) and the high-energy experimental terminal. The results indicate that the shielding thickness required for accelerating protons was the largest. Basing on the results, a method for estimating the lateral shielding of a high-energy proton/heavy-ion accelerator was proposed. A good agreement shows between the estimated results and the FLUKA calculated results, the validity and accuracy of the method were verified.     

2.45 GHz ECR离子源的微波阻抗匹配

ECR离子源的等离子体阻抗对其微波传输与阻抗匹配设计至关重要。在中国科学院近代物理研究所现有的2.45 GHz ECR 质子源上,对等离子体阻抗进行了测量。首先用水吸收负载代替等离子体负载测量得到了所用微波窗阻抗,然后根据质子源测量数据,推算得到了等离子体阻抗。实验结果表明,脊波导输出端阻抗与后续负载不完全匹配,等离子体阻抗随微波功率变化呈非线性。这些结果为ECR离子源过渡匹配和微波窗的设计提供了参考依据。Plasma impedance of an ECR ion source is important for microwave transmission and impedance matching design. Plasma impedance was measured indirectly with the 2.45 GHz ECR proton source at the Institute of Modern Physics, Chinese Academy of Sciences. In the test, we got microwave window mpedance by using water absorption load instead of plasma load, and the source plasma impedance was derived from the test data with the 2.45 GHz ECR proton source and microwave window impedance. The experimental results show that ridge waveguide output impedance and the subsequent load does not exactly match, plasma impedance variation is nonlinear with microwave power. The achievedresult is useful in the design of ridged waveguide and microwave window.     

强流ECR离子源引出系统研究

为了提高强流ECR 离子源的引出束流品质,分别设计了1# 和2# 引出系统,利用束流引出模拟软件PBGUNS 对1# 和2# 引出系统进行了质子束流引出与传输的模拟计算,结合实际测得的发射度数据分析引出系统,发现2# 引出系统比1# 引出系统引出束流品质高。对ECR 离子源引出系统的电势等位线分布等参数引起的球差进行了简单数学推导及MATLAB 绘图,并结合1# 和2# 引出系统束流相图模拟结果证明了球差会使引出束流品质有效发射度增长,通过适当加大电极孔径可改善束流聚焦情况,得到了束流光学聚焦较好的束流引出系统设计。To improve the quality of extracted ion beam from a high current ECR ion source, 1# and 2# extraction systems were designed and tested. The PBGUNS code was used to simulate the 1# and 2# extraction systems of proton ion beam. The emittance measurement results with the two different extraction systems were compared and analyzed with the simulation, the conclusion that more high quality beam extracted from 2# system than 1# system was got. The formula derivation of ECR ion source extraction system spherical aberration and MATLAB drawing was done by the analyzing on the distribution of extraction field equipotentials, effective emittance increasing caused by spherical berration was proved by 1# and 2# extraction systems beam phase space simulation result, beam focusing would be improved if electrode hole size increasing appropriately and a general concept on good optics focusing of ion beam extraction system was proposed finally.     

高电荷态ECR离子源引出束流4D 发射度测量仪设计

为了进一步探究高电荷态电子回旋共振(ECR) 离子源引出束流品质和横向相空间耦合情况,根据中国科学院近代物理研究所高电荷态离子源引出束流发射度测量需求,针对束流流强为1 eμA∼1 emA,能量范围为10∼35 keV/q 的直流或脉冲高电荷态重离子束,设计了一台实时四维Pepper-pot 发射度测量仪。该Pepper-pot 型发射度测量仪具有响应时间快和工作范围宽等特点。针对强流重离子束诊断的特点,在结构与材料选择上做了设计与优化,并对获得图像的处理方法提出了具体的解决办法。For the purpose of on-line beam quality diagnostics and transverse emittance coupling investigation of the ion beams delivered by an Electron Cyclotron Resonance (ECR) ion source, a real-time 4D Pepper Pot type emittance scanner is under development at IMP(Institute of Moden Physics, Chinese Academy of Sciences). The high charge state ECR ion source at IMP could produce CW or pulsed heavy ion beam intensities in the range of 1 eμA∼1 emA with the kinetic energy of 10∼35 keV/q, which needs the design of the Pepper Pot scanner to be optimized accordingly. The Pepper Pot scanner has many features, such as very short response time and wide dynamic working range that the device could be applied. Since intense heavy ion beam bombardment is expected for this device, the structure and the material selection for the device is specially considered during the design, and a feasible solution to analyze the pictures acquired after the data acquisition is also made.     

强流重离子RFQ加速器高频反馈控制研究

低能量强流重离子直线加速器装置(LEAF)是一台面向核天体物理、原子物理与材料辐照等多学科研究的强流高电荷态重离子直线加速器,由中国科学院近代物理研究所承担建设。LEAF强流离子束加速主要通过一台四翼型连续波RFQ实现,为实现其腔体各种复杂工况下的频率、幅度及相位的稳定控制,高频控制系统采用数字化低电平的方案。此低电平系统针对LEAF-RFQ的特殊要求开发了自动跟踪频率、双路功率源驱动、混合离子束快速切换相位等独特功能,实现了稳定地载束运行。同时,利用上位机程序实现了腔体的一键自动操作。     

低能强流质子束空间电荷补偿度研究(英文)

对于低能强流离子束来说,空间电荷效应的存在将导致束流发散、发射度增加等一系列问题,从而降低束流品质。幸运的是,当束流由离子源引出通过低能传输线时会与其中的剩余气体发生电离反应,产生二次电子与二次离子;二次电子在束流自身产生的电场作用下,在束流中积累并中和部分空间电荷,达到抑制空间电荷效应的效果。为了测量空间电荷中和程度,中国科学院近代物理研究所研制了一台三栅网式能量分析仪用以测量电离过程中产生的二次离子能量来间接计算空间电荷中和度。实验结果表明,对于40 keV, 18.5 mA的质子束,真空度为1.510*3 Pa 时得到最佳补偿度;真空度一定的情况下,空间电荷补偿度随束流流强增加而变大。For high-intensity low-energy ion beams, space charge effect is a main cause of beam divergence  and emittance growth. Fortunately, residual gas molecules in the drift space tend to be ionized and neutralize the beam space charge spontaneously. The level of Space Charge Neutralization (SCN)is measured through the detection of created secondary ion energy distribution in the beam region. A so-called non-interceptive Three-grid Energy Analyzer (TEA) has been designed and manufactured at Institute of Modern Physics, Chinese Academy of Sciences (IMP). This paper will present the detailsof the TEA detector and the application to diagnose proton beam SCN level in the Low Energy Beam Transport (LEBT) line. As a preliminary result, for an 18.5 mA proton beam a best compensating point appears at the vacuum pressure of 1.510*3 Pa. And the neutralization level is advanced with thegrowth of beam current in a constant vacuum pressure.     

400 MeV/u碳离子打靶的屏蔽参数计算

为了给医用重离子加速器提供一种专用的快速计算屏蔽厚度或对蒙特卡罗模拟结果进行验证的方法。采用FLUKA程序完成了400 MeV/u碳离子打不同靶的屏蔽参数计算。首先研究了打厚靶(铁、水)产生的次级辐射场的角度分布及主要成分;接着给出了不同角度范围下周围剂量当量在屏蔽体中的衰减曲线,通过拟合数据进一步得到不同角度范围下的辐射源项值H₀和衰减长度λ₀;最后结合莆田市医用重离子加速器治疗室的屏蔽设计,介绍了此套屏蔽参数的使用方法,通过与蒙特卡罗模拟结果的对比,证明了这套屏蔽参数的可靠性。该参数可为同类医用重离子加速器的屏蔽设计提供可靠的参考数据。