MWCNTs/hydroxypropyl cellulose/polyethylene glycol-based shape-stabilized phase change materials

Journal of Thermal Analysis and Calorimetry - Polyethylene glycol (PEG) is widely used as phase change materials (PCMs). However, the leakage and low thermal conductivity issues restrict its...     

Quantum Thermalization and Vanishing Thermal Entanglement in the Open Jaynes–Cummings Model

The quantum thermalization of the Jaynes–Cummings (JC) model in both equilibrium and non-equilibrium open-system cases is studied, in which the two subsystems, a two-level system and a single-mode bosonic field, are in contact with either two individual heat baths or a common heat bath. It is found that in the individual heat-bath case, the JC model can only be thermalized when either the two heat baths have the same temperature or the coupling of the JC system to one of the two baths is turned off. In the common heat-bath case, the JC system can be thermalized irrespective of the bath temperature and the system–bath coupling strengths. The thermal entanglement in this system is also studied. A counterintuitive phenomenon of vanishing thermal entanglement in the JC system is found and proved.     

Inequality Estimates of an Inhomogeneous Semilinear Biharmonic Equation in Entire Space

Acta Mathematicae Applicatae Sinica, English Series - In this paper, we consider the inequality estimates of the positive solutions for the inhomogeneous biharmonic equation (*)$$-\Delta^{2}...     

An Endoplasmic Reticulum Targeting Type I Photosensitizer for Effective Photodynamic Therapy against Hypoxic Tumor Cells

Organelle-targeted type I photodynamic therapy (PDT) shows great potential to overcome the hypoxic microenvironment in solid tumors. The endoplasmic reticulum (ER) is an indispensable organelle in cells with important biological functions. When the ER is damaged due to the production of reactive oxygen species (ROS), the accumulation of misfolded proteins will interfere with ER homeostasis, resulting in ER stress. Here, an ER-targeted benzophenothiazine-based photosensitizer NBS-ER was presented. ER targeting modification significantly reduced the dark toxicity and improved phototoxicity index (PI). NBS-ER could effectively produce O₂⁻⋅ with near-infrared irradiation, making its phototoxicity under hypoxia close to that under normoxia. Meanwhile, the photoinduced ROS triggered ER stress and induced apoptosis. In addition, NBS-ER possessed excellent photodynamic therapeutic effect in 4T1-tumor-bearing mice.     

The Hamilton–Waterloo Problem for ‐Factors and ‐Factors

The Hamilton–Waterloo problem asks for a 2‐factorization of (for v odd) or minus a 1‐factor (for v even) into ‐factors and ‐factors. We completely solve the Hamilton–Waterloo problem in the case of C₃‐factors and ‐factors for .     

Rapid and sensitive lateral flow immunoassay method for determining alpha fetoprotein in serum using europium (III) chelate microparticles-based lateral flow test strips

Alpha-fetoprotein (AFP), a primary marker for many diseases including various cancers, is important in clinical tumor diagnosis and antenatal screening. Most immunoassays provide high sensitivity and accuracy for determining AFP, but they are expensive, often complex, time-consuming procedures. A simple and rapid point-of-care system that integrates Eu (III) chelate microparticles with lateral flow immunoassay (LFIA) has been developed to determine AFP in serum with an assay time of 15 min. The approach is based on a sandwich immunoassay performed on lateral flow test strips. A fluorescence strip reader was used to measure the fluorescence peak heights of the test line (H_T) and the control line (H_C); the H_T/H_C ratio was used for quantitation. The Eu (III) chelate microparticles-based LFIA assay exhibited a wide linear range (1.0–1000 IU mL⁻¹) for AFP with a low limit of detection (0.1 IU mL⁻¹) based on 5ul of serum. Satisfactory specificity and accuracy were demonstrated and the intra- and inter-assay coefficients of variation (CV) for AFP were both <10%. Furthermore, in the analysis of human serum samples, excellent correlation (n = 284, r = 0.9860, p < 0.0001) was obtained between the proposed method and a commercially available CLIA kit. Results indicated that the Eu (III) chelate microparticles-based LFIA system provided a rapid, sensitive and reliable method for determining AFP in serum, indicating that it would be suitable for development in point-of-care testing.     

快原子轰击离子化质谱研究酚类化合物抗氧化作用

为了建立简便、快速筛选高效、低毒的新型抗氧化药物的方法,本研究采用快原子轰击离子化质谱( FAB-MS)对酚类化合物抗氧化作用强弱进行了研究。考察了基质、轰击时间和样本浓度对FAB-MS 谱中分子离子(M+·)相对强度的影响,研究了黄酮类化合物在FAB-MS谱中的I(M+·)/I([M+H]+)比值与其抗氧化活性的相关性。对12种酚类化合物的抗氧化活性进行了预测与评价,并与硫代巴比妥酸法( TBA)检测的脂质过氧化抑制率进行比较,验证 FAB-MS 方法的可靠性。结果表明,由 FAB-MS 获得的 I ( M+·)/I([ M+H]+)比值能较好地反映酚类化合物抗氧化作用的强弱,可以作为抗氧化剂的体外筛选或预测方法,有助于加速新型抗氧化药物的发现。     

三嗪类农药类特异性分子印迹聚合物的合成及其应用

以莠去津为模板,甲基丙烯酸为功能单体,三羟甲基丙烷三甲基丙烯酸酯为交联剂,采用本体聚合法制备了一种对5种三嗪类农药及其3种主要代谢物选择性好、吸附能力强的类特异性分子印迹聚合物,并建立了玉米、小麦及棉花样品中该8种农药的分子印迹固相萃取/高效液相色谱-串联质谱(MISPE/HPLCMS/MS)检测方法。筛选了模板分子与功能单体的配比,表征了印迹聚合物的形态,研究了印迹聚合物及以其为填料的固相萃取柱对三嗪类农药的识别特性。结果表明,印迹聚合物对模板分子及其结构类似物具有很强的亲和力与类特异性,其固相萃取小柱具有很好的选择性和净化能力。在玉米、小麦及棉花等实际样品中8种三嗪类农药的加标回收率为61.1%~107.6%,相对标准偏差(RSD)小于11%,检出限(S/N=3)为0.4~8.1μg/kg。此方法可用于实际样品的常规监测。     

农产品中6种有机溶剂残留的气相色谱-质谱检测方法

建立了蔬菜、粮食等农产品中6种有机溶剂残留(甲苯、邻二甲苯、间二甲苯、对二甲苯、N,N-二甲基甲酰胺(DMF)和二甲基亚砜(DMSO)的液液萃取/气相色谱-质谱分析方法。不同类型的样品经乙腈-水溶液或乙腈溶剂提取后,用Agilent DB-624(30.0 m×250μm×1.4μm)毛细管色谱柱分离,在GC-MS选择离子监测(SIM)模式下检测,以保留时间和特征离子丰度比定性,外标法定量。结果表明,该方法对不同样品中4种苯系物在0.005~0.500 mg/L,DMF在0.025~0.125 mg/L,DMSO在0.050~0.500 mg/L浓度范围内线性关系良好,相关系数(r)为0.992 0~0.997 1。6种有机溶剂的平均加标回收率为60.1%~115.2%,相对标准偏差不大于11.0%。苯系物、DMF和DMSO的方法检出限(S/N=3)分别为0.002~0.050,0.010~0.025,0.060~0.150 mg/kg。该方法准确、快速、灵敏,可用于各种农产品中有机溶剂残留的监控。