脂肪族聚酯及共聚酯的生物降解性研究

以酯交换法或直接缩聚法合成了一系列脂肪族聚酯，经二异氰酸酯(HDI)扩链得到含氨酯键的聚酯及共聚酯，用DSC、X射线衍射等分析表征了聚酯及共聚物的结构和性能。用土埋试验、CO2释放试验和黑曲霉降解试验着重研究了这些聚合物的生物降解性，详细讨论了聚酯结构、组成及聚酯分子量对生物降解性的影响。     

淀粉/聚酯体系生物可降解材料

主要从淀粉／聚酯共混、聚酯—淀粉—聚酯复合层、交联及生物降解性方面综述了近年来淀粉/聚酯体系的生物可降解材料的研究进展。     

聚琥珀酸丁二酯的辐射交联和它的热变形行为

近年来 ,塑料废弃物污染环境的问题日趋严重 .对于环境的关心 ,已经使越来越多的科研人员对于研究环境友好化合物的发展产生了极大的兴趣 .发达国家先后制订了限制或禁止某些场合使用非降解性塑料 ,因此 ,多种可生物降解性塑料已经发展起来 .目前已经商业化的可生物降解性聚合物主要有脂肪族聚酯、聚醚、聚乙烯醇和聚多糖 .其中 ,利用化学合成法开发的可生物降解性聚合物是非常重要的 .脂肪族聚酯 ,例如聚乳酸(ＰＬＡ) .聚乙二酸 (ＰＧＡ)等被广泛地用于药物的载体[1] ,聚 (ε 己内酯 ) (ＰＣＬ)也已经被用作生产生物降解性薄膜 .脂肪族聚酯…     

开环可控聚合制备脂肪族聚酯的最新研究进展

近年来,作为生物降解高分子材料,脂肪族聚酯由于良好的生物降解性及生物相容性受到人们的广泛关注。脂肪族聚酯在环境友好材料和生物医用材料领域都具有极大的应用价值,目前,部分聚酯材料已经商品化。与此同时,脂肪族聚酯的合成方法尤其是活性开环聚合也成为学术界及工业领域的研究热点。采用开环聚合法得到的聚合产物化学组成精确、分子量分...     

合成生物降解性聚酯研究的进展

对近年来采用化学法,主要是缩合聚合法及开环聚合法,合成生物降解性聚酯的研究进展作了综述。     

可生物降解聚酯酰胺共聚物的合成与表征

以两种合成的酰胺二元醇和癸二酸为原料合成了可生物降解的聚酯酰胺共聚物,研究了该癸半晶性聚合物的合成、结晶及其生物降解性,并应用ＩＲ,＾１Ｈ ＮＭＲ,ＳＥＭ及ＤＳＣ进行了表征。     

生物降解PBS聚醋的改性研究进展

聚丁二酸丁二醇酯(PBS)是一种具有良好生物降解性的聚酯,本文简述了PBS的基础物性和力学性能,综述了各种改善PBS生物降解性、生物相容性、热学和力学性能的方法,重点介绍了通过共聚、共混等方法对PBS进行改性的研究进展.     

纳米TiO2-TBOT复合催化生物可降解脂肪-芳香族共聚酯合成的研究

以TiCl4为原料,采用溶胶-凝胶法制备了纳米级的TiO2,并用XRD和TEM等手段进行了表征,并以TiO2-TBOT(钛酸四丁酯)为催化剂,1,4-丁二醇、己二酸和对苯二甲酸二甲酯为原料制备了聚己二酸丁二醇酯和对苯二甲酸丁二醇酯的共聚物,对共聚物的相对分子质量、断裂拉伸强度和断裂伸长率进行了测试,以各反应的时间长短、共聚酯的分子量的高低和力学性能对催化剂性能进行了考察.并采用堆肥埋片法,以失重率作为降解性指标,考察了含芳香组分为40%、50%和60%摩尔分数的三种共聚酯的生物降解性.结果表明,纳米TiO2与TBOT的复合催化剂具有良好的催化性能,当TBOT/TiO2比例为1.2时,所制备共聚酯的重均分子量达到82000.在脂肪族聚酯中引入摩尔分数为40%～60%的芳香族组分,所制备的共聚酯具有较好的力学性能和生物降解性;且随着所含芳香组分的增多,生物降解性变差.     

聚乳酸共混体系的研究进展

聚乳酸是人工合成的可生物降解的热塑性脂肪族聚酯 ,是一种环境友好的材料 ,逐渐成为人们研究的热点。本文根据聚乳酸共混体系中另一组分的生物降解性 ,将聚乳酸共混体系分为完全可生物降解共混体系和部分可生物降解共混体系两类。针对体系的相容性和结晶结构以及在提高PLA的性能和降低成本等方面 .综述了聚乳酸共混体系的最新研究进展 ,并对其发展动态进行了简要介绍     

侧链含羟基聚(D,L-丙交酯-co-碳酸酯)的合成与表征

聚乳酸(PLA)具有良好的生物相容性及可生物降解性,是适用于组织工程及药物释放系统的聚酯材料,一直是生物医用材料领域中研究的热点之一[1,2].但由于这类聚酯材料是疏水性的,因而存在多肽、蛋白质药物包覆量太低,控释系统制备过程及存放过程中易于失活及药物释放过程难于控制等     

Synthesis,thermal, rheological characteristics,and enzymatic degradation of aliphatic polyesters with lignin‐based aromatic pendant groups

This research aims to produce lignin‐based biodegradable polyesters with improved thermal quality. A series of aliphatic polyesters with lignin‐based aromatic side groups were synthesized by conventional melt‐polycondensation. Decent molecular weight (21–64 kg mol^?1) was achieved for the polymerizations. The molecular structures and thermal and mechanical properties of the obtained polyesters were characterized. As a result, the obtained polyesters are all amorphous, and their glass‐transition temperature (T_g) depends on the size of the pendant aromatic group (31–51 °C). Furthermore, according to the TGA results, the thermal decomposition temperatures of the polyesters are all above 390 °C, which make them superior compared with commercial biodegradable polyesters like polylactic acid or polyhydroxyalkanoates. Finally, rheological characteristics and enzymatic degradation of the obtained polyesters were also measured. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2314–2323     

Multifunctional Polyesters for Bioartificial Vascular Prostheses

Aliphatic polyesters of controlled molecular weight and low molecular weight distribution were prepared via anionic ring-opening polymerization using a multifunctional star-shaped initiator. Functionalization results in star-shaped functional polyesters bearing methacrylate end groups. Novel biodegradable polyester resins were prepared by photochemical crosslinking of the functional polyesters. Three-dimensional microstructuring via UV replica molding shows the potential of this material as substrate for biomedical devices.     

PBS基生物降解材料的研究进展

PBS(聚丁二酸丁二醇酯 )是一种具有良好生物降解性的聚酯塑料。本文简述了PBS的基本特性、降解机理和制备方法 ,对各种PBS基生物降解材料的特性进行了分析 ,介绍了PBS基生物降解材料的研究进展     

Biodegradable materials by reactive extrusion: from catalyzed polymerization to functionalization and blend compatibilization

This contribution aims at reviewing how reactive extrusion (REx) technique can participate in the design and development of biodegradable polymeric materials more particularly based on aliphatic polyesters issued from both renewable (agrochemical) and fossil (petrochemical) resources. On one side, REx will be approached for producing in a continuous way biodegradable aliphatic polyesters by ring-opening polymerization of lactones. Tin and aluminum-based catalysts will be considered for quantitatively converting the cyclic monomer in high molecular weight polyester chains within residence time of a few minutes only. On the other hand, such polyesters will undergo various chemical modifications again performed by REx. Self-branching reactions will be investigated in order to compensate the characteristic molecular weight reduction of the polyester chains as triggered by hydrolysis and/or transesterification side-reactions. Controlled functionalization reactions by maleic anhydride treatment will be studied as well. Finally biodegradable composite materials will be produced by REx and will rely upon the interface compatibilization between the polyester matrix and natural fillers such as starch granules or talc microparticles. To cite this article: J.-M. Raquez, et al., C. R. Chimie 9 (2006).     

酶催化生物可降解聚酯的合成与研究进展

生物可降解聚酯是一种新型高分子聚合材料,可通过发酵、化学方法和酶催化来合成.本文综述了酶催化下通过缩聚、酯交换、内酯开环聚合等方法合成此类聚酯.酶催化合成生物可降解聚酯是一种新型的技术,可以在温和条件下高效合成,有着传统方法难以比拟的优势.     

酶催化脂肪族聚酯的合成

脂肪族聚酯是一种可生物降解的新型高聚物,可通过化学催化、发酵和酶催化来合成.酶催化合成聚酯是一种新型的环境友好绿色化学技术,可以在温和条件下高效的合成聚酯,有着传统聚合方法难以比拟的优势.尤其是特种酶的应用,为传统方法难以合成的聚酯,开辟了一条新的合成途径.本文综述了脂肪酶催化缩聚、酯交换、内酯开环聚合等聚酯合成方法,并讨论了反应参数(如溶剂、温度、酶和单体的浓度)对反应的影响.     

Metabolically Active,Fully Hydrolysable Polymersomes

The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.     

Properties of Starch Blends with Biodegradable Polymers

Abstract

Starch, one of the most inexpensive and most readily available of all natural polymers, can be processed into thermoplastic materials only in the presence of plasticizers and under the action of heat and shear. Poor water resistance and low strength are limiting factors for the use of materials manufactured only from starch, and hence the modification of starch is often achieved by blending aliphatic polyesters. In this review, the literatures concerning the properties of various blends of starch and aliphatic polyesters have been summarized. The biodegradable rates of blends can be controlled to a certain extent depending on the constitutions of blends, and the mechanical properties of blends are close to those of traditional plastics such as polyethylene and polystyrene. The reduction of their sensitivity to humidity makes these materials suitable for the production of biodegradable films, injection-molded items, and foams.     

Metabolically Active,Fully Hydrolysable Polymersomes

The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.