高分子成型加工创新性实验体系

针对目前高分子专业成型加工实验课程各环节缺乏相互联系,无法实现对学生专业素质综合培养的不足,将原本各自独立的实验内容加以整合,建立综合性、系统性的创新性实验体系.高分子成型加工创新性实验体系参照高分子材料加工企业的生产模式,划分为配方设计和成型加工工艺两个紧密联系的实践教学环节.通过征集科研课题和企业难题、学生自己制定...     

《聚合物成型加工》课程教学改革初探

<聚合物成型加工>作为本科院校高分子材料与工程专业的必修专业课程,在教学过程中要坚持理论教学和实践教学两手抓,既要使学生掌握一定的理论基础,又要培养学生的实践应用能力.针对本校的培养"应用型人才"的培养方针,围绕聚合物成型加工课程的理论基础,我们在实践教学体系改革的过程中,改变了原有独立的、缺乏直接联系的实验内容,建立...     

《聚合物改性》课程线上教学的探索

本文分析了新冠疫情形势下《聚合物改性》课程线上教学实施的问题.依托"QQ课堂"和"超星学习通"平台,通过"在线讲授理论环节"和"居家实验"相结合的形式,开展了融"理论+实践"为一体的《聚合物改性》课程在线教学.把需要在实验室完成的实验生活化,既锻炼了学生的动手能力又能尝试自己制作的美食,既激发了学生的学习兴趣,又进行了...     

高分子科学实验教学改革初探

设想将高分子化学、高分子物理和高分子成型加工三门实验课程有机地串联起来,组建成一门包括从高分子材料设计(用计算机软件进行分子设计、性能模拟)、聚合物合成、性能测试(物性表征)到加工成型(制作成高分子材料制品),能环环相扣、互动式的、柔性化的高分子科学实验课程;提出了初步的实践方案.     

工程教育专业认证背景下聚合物加工流变学课程教学改革探讨

聚合物加工流变学具有理论性深和实践性强的课程特点，是依托高分子物理基础，服务聚合物成型工艺学和塑料成型模具设计的专业基础课，它在高分子材料与工程专业本科教学体系中承载着纽带作用。针对课程目前的教学现状，以工程教育专业认证理念为指引，本文根据专业特色和实际情况，提出了课程改革的思路，对课堂教学、实验教学和教学方法进行了改革探讨。重新构建课程教学体系更为合理和完善，改革后的课堂教学内容结构进一步优化，提出开设的线上微实验课程弥补了流变学实验教学的缺失，教学方法动、静结合更为多元化。通过改革实践，学生的流变学理论知识更扎实，运用流变学知识分析解决问题的能力提升，课程教学质量得到显著提高。     

研究性与系统性相结合的有机合成实验教学实践

为了培养学生的创新能力和实践能力,使学生较全面地掌握有机合成实验理论知识和实验技能,开展了有机合成实验研究性和系统性结合的教学探索和实践。在课程建设和教学过程中,贯彻以学生为主体的教学改革思路与方法。从教学内容和模式、授课方式、考核方式等多个教学环节进行探索研究,科教融合,结合实际课堂教学,倡导启发式教学方法。研究型教学模式的实施有效地调动了学生自主研究性学习的积极性,有利于提高学生的综合实践能力,促进实验教学与科学研究的衔接。     

《聚合物共混改性》课程现状及改革建议

《聚合物共混改性》是高分子材料与工程专业的一门专业课程,具有综合性、实践性及前沿性等特点。本文根据课程的特点,结合笔者课堂和实践教学的经验,阐述了该课程目前存在的教学现状及普遍存在的问题:学生对课程学习的疲倦、授课方式单一、缺少实践、教材陈旧及考核方式不完善等,并由此从授课模式、教学内容、教学体系、考核方式多个方面提出了课程教学改革的一些见解,以期激发学生的学习兴趣,有效提高教学效果,为培养应用型、创新型人才奠定基础。     

《高分子材料成型加工新技术》课程教学改革探索

《高分子材料成型加工新技术》是在《聚合物加工机械》和《聚合物加工原理》两门本科专业课基础上发展形成的一门技术前沿性的新课程。该课程主要讲授当前高分子材料成型加工的新装备、新技术和新方法等,既可作为高分子材料与工程专业本科生拓宽专业知识面的专业选修课,也可作为材料加工工程专业硕士研究生的专业主干课。本文结合课程团队多年给研究生讲授《高分子材料成型加工新技术》专业主干课的经历,从教学目标、教学内容、教学方法和教学效果四个方面介绍了开设这门课程的经验和体会。     

聚合物材料改性课程教学改革与实践

聚合物材料改性是高分子学科研究生课程体系中的重要专业课之一。该课程具有综合性、实践性及前沿性的特点。针对该课程的特点及高等教育改革的需要,对聚合物材料改性教学现状及存在的问题进行了分析,从教学体系、教学内容、教学方法、教学手段、考核方式多个方面提出了课程教学改革的一些见解,以期在有限的学时内取得较好的教学效果。实践表明,聚合物材料课程教学改革与实践探索在激发学生兴趣,提高学生的综合能力上已经初见成效。     

基于翻转课堂的《高聚物成型加工》教学模式初探

翻转课堂的教学模式可以为学生提供更多主动参与学习的机会,缓解了传统课堂中忽视学生自主学习和缺乏教学针对性的问题,从而受到了教研工作者的普遍关注。本文在分析《高聚物成型加工》的课程特点的基础上,提出根据课程性质和课程结构的差异性进行不同形式课程翻转的思想,将《高聚物成型加工》课程划分为理论基础和成型工艺两个部分,分别采用不同的翻转课堂教学模式,并从自主学习的有效性和学习时间的有限性对翻转教学的难点进行分析,并提出了解决方法。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.