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Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates |
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| Authors: | George E Magoulas Thomas Garnelis Constantinos M Athanassopoulos Dionissios Papaioannou George Mattheolabakis Konstantinos Avgoustakis Dimitra Hadjipavlou-Litina |
| Institution: | 1. Laboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece;2. Department of Pharmacy, University of Patras, 26504 Patras, Greece;3. Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
| Abstract: | (E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C60, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine. |
| Keywords: | Fullerenes Polyamines Conjugates Anti-inflammatory activity Lipoxygenase inhibitors DAEBYKNDHATTDI-NJNXFGOHSA-N KHZYAXPYLLRHFP-FNORWQNLSA-N YHQNTSKTJZRZJM-KJEVSKRMSA-P CWQIVMYFLJKEEL-DAUPPJBDSA-N VMXQWRZSIZQAHU-QHHAFSJGSA-N JNBFHQCIFRVOIE-CLNHMMGSSA-Q YGMZMQBGEOEZET-UHFFFAOYSA-N KECKCXHGOANKRB-ZZIIXHQDSA-N ZMRNAIMHRKNWEL-SDNWHVSQSA-N HLVQPAJLQUBEBE-AYKLPDECSA-N AAINVNZHOVLZHM-GXDHUFHOSA-N XDUPBDDDCRDPGX-UHFFFAOYSA-N IHWBKGQYXMVUPQ-NTEUORMPSA-N KOYZNKHYCSRDQE-SYSTYOMDSA-N CNBCZPVJQARHEN-WEVVVXLNSA-N SBCKVSDGHQYYEL-MUVRPNDMSA-N GQRIPUXKGZZFRC-UHFFFAOYSA-N WNJHSYJWTAWXEB-JKBLJYNNSA-Q NLMIBUAKWKGOIP-IFJLIMJSSA-N UHHRTJITGLTMQK-XBXARRHUSA-N GRNIJBXQYRWVDV-KJEVSKRMSA-P QIQALDKRRWPJLW-UHFFFAOYSA-N BXWVXCXWIUCXHR-UHFFFAOYSA-N WTMZLGCXVBDBFR-VMPITWQZSA-N DKWURBGYXUGNRT-UZPIQWQOSA-N |
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