共查询到20条相似文献,搜索用时 62 毫秒
1.
2.
以深度参与美国加州大学洛杉矶分校(UCLA)的课程学习的经验和体会为基础,对该校在人才培养理念、化学专业设置与课程体系、实验课程教学方式与要求、科研创新实践活动等方面的做法进行了梳理和总结。UCLA以学生为中心的教育理念、模块化且循序渐进的课程设置、丰富的实验课及科研实践活动,以及对安全的高度重视等,对我国高校培养创新型化学人才有很好的借鉴意义。 相似文献
3.
4.
设计不同维度的课程任务学习单,并将自主探究、协作交流等学习模式引入物理化学实验的实践教学,深入探讨了物理化学实验课程实施翻转课堂的教学模式的研究。整个教学环节包括:课前资源导学、课内知识拓展、课后成效评价。实践表明,翻转课堂有利于提高学生的知识内化能力、分析解决问题能力、合作交流能力以及自学能力,尤其是文献调研的能力有显著提升,该模式取得了较好的教学效果。 相似文献
5.
6.
"问题解决"策略方法是以学生为中心的教学模式,能激发学生的学习兴趣和主观能动性。结合高等农业院校的教学现状和物理化学课程特点,将其应用到具体的教学实践中。经过课堂过程设计、教学法实践的准备、教学实践及教学评价,说明该方法能较大提高物理化学课程的学习效果。 相似文献
7.
持续改进理念要求从教学管理到课程逐级落实持续改进的评价机制。过程性评价被广泛应用于课程教学评价中,但存在重形式轻反馈、重结果轻改进等缺陷。基于质量管理方法建构了“教学目标—教学实施—教学评价—教学改进”教学评价体系的PDCA循环模式。该模式实现了培养目标、教学活动和评价的一致性;“他评—互评—自评—改进”评价循环实现迭代成长性评价;“前测—讲新—内化—巩固”教学循环保障教学目标的符合和达成;“亮考帮”激发学习兴趣,增强学习内驱力。实践表明,教学评价体系的PDCA循环模式可实现以评为学、以评促学、以评促教,发挥过程性评价对学生的指挥棒作用,诊断和改进教学,为持续改进理念在课程中的落地提供了一条有效路径。 相似文献
8.
9.
10.
面向研究生的仪器分析实验课程如何从教学方式、教学内容上进行改革,提高教学质量,南开大学中心实验室进行了有益的尝试。以色谱分析实验为例,通过在线课程拓展学生理论学习的时空域;丰富实验内容与分组实验相结合,提升了学生的学习热情,加强了学生实际操作的训练;以科研工作为驱动力的研究型实验课程安排更加契合学生的实际需求,增强了学生的主动学习意识,培养了学生的实际工作能力。教学实践表明,课程改革收到了较好的效果。新的教学模式提高了学生的实践能力,对新的仪器方法学习有助于其科研创新工作的开展。 相似文献
11.
Uroš Grošelj Mojca Žorž Amalija Golobič Branko Stanovnik Jurij Svete 《Tetrahedron》2013,69(52):11092-11108
A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives. 相似文献
12.
The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp3)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp2)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp2)?H and aliphatic 1,5- and 1,6-C(sp3)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp3)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp2)?H insertion. 相似文献
13.
N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%). 相似文献
14.
Shashikant U. Dighe Surya K. Samanta Shivalinga Kolle Sanjay Batra 《Tetrahedron》2017,73(17):2455-2467
An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y1 and Y2. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones. 相似文献
15.
In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates. 相似文献
16.
Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described. 相似文献
17.
用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在. 相似文献
18.
19.
Jona Mirnik Eva Pušavec Kirar Sebastijan Ričko Uroš Grošelj Amalija Golobič Franc Požgan Bogdan Štefane Jurij Svete 《Tetrahedron》2017,73(24):3329-3337
A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu0 as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than CuI in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT). 相似文献
20.
George E. Magoulas Thomas Garnelis Constantinos M. Athanassopoulos Dionissios Papaioannou George Mattheolabakis Konstantinos Avgoustakis Dimitra Hadjipavlou-Litina 《Tetrahedron》2012,68(35):7041-7049
(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C60, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine. 相似文献