5-溴-6-甲氧基-2-丙酰基萘的钯催化氢化脱溴

溴甲氧基丙酰基萘;5-溴-6-甲氧基-2-丙酰基萘的钯催化氢化脱溴     

氯化铜对6-甲氧基-2-酰基萘选择性氯化反应

甲氧基酰基萘;甲氧基萘;氯化铜对6-甲氧基-2-酰基萘选择性氯化反应     

6-甲氧基-2-丙酰基萘在醇溶剂中的溴化反应

室温下，6－甲氧基－2－丙酰基萘和1，3－二溴－5，5－二甲基海因的溴化反应在醇溶剂中，反应速度快、转化率高，生成5－溴－6－甲氧基－2－丙酰基萘的收率高（98．59％）。     

2-乙酰基-6-甲氧基萘的多相催化氢化

乙酰基溴甲基萘;甲氧基萘基;2-乙酰基-6-甲氧基萘的多相催化氢化     

(2S)-(+)-2-溴-1-(6'-甲氧基-2'-萘基)丙-1-酮的不对称合成

以(2R,3R)-酒石酸二甲酯为手性辅助剂,6-甲氧基-2-丙酰基萘经缩酮化、溴化铜不对称溴化、水解等反应合成了(2S)-2-溴-1-(6'-甲氧基-2'-萘基)丙-1-酮。总收率94%。     

2—甲氧基—6—丙酰基萘的合成

2-甲氧基-6-丙酰基萘1,是(s)-(+)-2-(6-甲氧基-2-萘基)丙酸(萘普生,一种非甾体消炎镇痛药)的大多数新合成路线的关键中间体。2-甲氧基-6-丙酰基萘是通过2-甲氧基萘的Friedel-Crafts酰基化反应制得。由β-     

4-(6-甲氧基-2-萘基)-2-(2-羟苄亚氨基)噻唑合成与表征

6-甲氧基-2-(2-溴酰基)萘与硫脲反应环合得4-(6-甲氧基-2-萘基)-2-氨基噻唑;后者与水杨醛反应制备了新化合物4-(6-甲氧基-2-萘基)-2-(2-羟苄亚氨基)噻唑,收率为72.1%～94.8%.目标物采用核磁共振、红外光谱和元素分析测试技术进行了表征;分析目标物和中间体中萘环质子偶合分裂情况.并且确定了萘环上各质子的归属.     

氯化铜对芳基烷基酮的选择性氯化反应

氯化铜对芳基烷基酮的选择性氯化反应;氯代苯丙酮;甲氧基丙酰基萘;甲氧基乙酰基萘;甲氧基苯乙酮     

2-卤乙基-2-(6’-甲氧基-2’-萘基)-4-甲基-1,3-二氧杂环戊烷重排合成外消旋体萘普生

以溴化铜或氯化铜为卤化剂 ,6-甲氧基 -2 -丙酰基萘经羰基 α-卤化、1 ,2 -丙二醇缩酮化、醋酸锌或氧化锌催化重排和水解等反应合成外消旋体萘普生 ,总收率为 85 %～ 90 .4% (以 6-甲氧基 -2 -丙酰基萘计 ) .“一锅法”重排合成外消旋体萘普生 ,不需分离中间体 ,操作简便、收率高 .以氯化铜为卤化剂、氧化锌为催化剂的重排合成工艺较佳     

2-芳基-2-吗啉醇的合成

醇胺分别与2-溴-4′-甲氧基苯乙酮、2-溴-3′-氯苯丙酮、2-溴-4′-苄氧基苯基丙酮、2-溴-4′-苄氧基苯戊酮、6-甲氧基-2-溴乙酰基萘和6-甲氧基-2-(2-溴丙酰基)萘反应,合成相应的2-芳基-2-吗啉醇(产率80.7%～97.5%)及其盐酸盐.其结构经1H NMR,IR,MS确证.     

Kalorimetrische Untersuchungen zum mikrobiellen Abbau schwerlöslicher Schadstoffe am Beispiel von Naphthalin

The bacterial degradation of naphthalene and other PAH in liquid media by pure cultures was investigated by an isothermic flow-calorimeter. Anabolic and catabolic processes were found to be separated distinctly. The phase of exponential heat production was developed only weakly. This was attributed to the low solubility and the dependence of the dissolving rate of substrate as the rate determining step on cristal surface and diffusion.Methodical problems based on the local separation of the fermenter and the measuring cell. Because of the prevented gas exchange in the flow tubes and the enrichment of carbon dioxide metabolic activity of the microorganisms was lowered for times. The differences between the heat production in the fermenter and the flow tubes were reduced by developing a mathematical model.

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Voltammetric Assay of Naproxen in Pharmaceutical Formulations Using Boron‐Doped Diamond Electrode

The electrooxidation of naproxen was studied, for the first time, using boron‐doped diamond (BDD) electrode by cyclic and differential pulse voltammetry (CV and DPV) in nonaqueous solvent supporting electrolyte system. The results were also compared with glassy carbon electrode (GC) under the same conditions. Naproxen undergoes one electron transfer resulting in the formation of cation radical for the first electrooxidation step, which follows other chemical and electrochemical steps such as deprotonation, removal of another electron and the attack of nucleophile (ECEC mechanism). BDD electrode provided higher signal to background ratio, well resolved and highly reproducible cyclic voltammograms than the GC electrode. With a scan rate of 50 mV s^?1 and pulse height of 50 ms, respectively, the DPV technique was able to determine the naproxen concentrations in the range of 0.5 to 50 μM with a detection limit of 30 nM. The influence of interference compounds namely 2‐acetyl‐6‐methoxy naphthalene (AMN) on naproxen oxidation can also be followed successfully. Moreover, the percentage of AMN present in the standard chemical form of a mixture containing naproxen can be found accurately. Rapidity, precise and good selectivity were also found for the determination of naproxen in pharmaceutical formulations.     

用乳化液膜法从萘油直接制取精萘的研究

本研究依据乳化液膜分离技术的原理，采用阴离子表面活性形成的乳化液膜从萘油直接制取精萘，考察了各种工艺条件对精萘产品质量和收率的影响。实验结果表明，以阴离子表面活性剂形成的乳化液膜结合精馏可有效地将萘油制成精萘，萘含量大于９９％，符合国家精萘标准，萘收率大于８８％。     

苯基取代的苯并噻唑胺双苯甲酰胺衍生物的合成及生物活性

以取代苯甲酸和取代邻氨基苯甲酸为起始原料,设计合成了13个含取代苯并噻唑胺邻甲酰氨基苯甲酰胺类化合物,其结构经1H NMR、13C NMR、IR及元素分析确证。 初步生物活性测试结果表明,在500 mg/L目标化合物浓度下,对黄瓜花叶病毒有一定抑制作用。 采用MTT法进行化合物抑制PC3癌细胞体外活性测试,结果表明,所合成的化合物具有不同程度的抑制PC3癌细胞活性,其中化合物4f在10 μmol/L浓度下对PC3的抑制率为74.2%。     

以工业萘和粗甲基萘为主要原料合成萘系高效减水剂

工业萘、粗萘、甲基萘或萘残油等均可作为制取萘高效减水剂的原料。目前 ,其主要原料工业萘出现全球性紧缺 ,价格不断上扬[1] 。而攀枝花粗甲基萘比工业萘便宜许多 ,如果能用粗甲基萘代替工业萘生产萘系高效减水剂 ,可降低成本 ,使之具有更大的市场竞争力。前期实验表明单独使用粗甲基萘制备的减水剂 ,其减水率虽然较高 ,但产品含气量较大且引气不均匀 ,使混凝土抗压强度达不到要求。为了将工业萘和粗甲基萘混合物作为原料制备高效减水剂 ,并尽量用粗甲基萘替代工业萘 ,我们做了大量的实验 ,寻求到了工业萘和粗甲基萘混合物作为原料制备高效…     

Efficient Synthesis of 1-Deaza-6-methoxypurine-N9-β-2′-deoxyribonucleoside and Related DNA Building Blocks

An improved synthesis of the 2′-deoxyribonucleoside containing 1-deaza-6-methoxypurine as artificial nucleobase is described. By optimizing the conditions for the deprotection of p-toluoyl-protected 1-deaza-6-nitropurine 2′-deoxyribonucleoside, the isolated yield of the title compound could be increased from 15% to 90%. In addition, the synthesis and characterization of the corresponding 5′-(4,4′-dimethoxytrityl) (DMT) protected phosphoramidite, a potentially useful building block for the synthesis of artificial oligonucleotides, is reported. The title compound offers interesting hydrogen bond donor and metal-binding properties for its application in metal-mediated base pairs.

含萘结构的新型苦参碱衍生物的合成

以二异丙基氨基锂和氢化钠为亲核试剂,THF为溶剂,苦参碱和萘类化合物为原料,设计并合成了10个含萘结构的新型苦参碱衍生物［14-萘羟次甲基苦参碱(3a~3c), 14-萘甲酰基苦参碱(3g~3j)和14-萘甲烯基苦参碱 (3d~3f)］,其结构经¹H NMR, ¹³C NMR, FT-IR和ESI-MS表征。     

1-甲氧基-1-烷硫基丙烷的合成

甲氧基烷硫基丙烷;丙缩醛;硫醇;1-甲氧基-1-烷硫基丙烷的合成