地方应用型高校材料化学专业人才培养体系的构建

论述了应用型地方高校材料化学专业构建稳定的人才培养体系的必要性和紧迫性。结合教学实践重点阐述了在课程体系设置、课堂教学、实验教学、校外实践等教学环节的改革,以及师资素质培养和转型、专业差异化发展、与地方经济融合等方面的有益探索。通过数据展现了在新的培养体系中取得的积极效果。最终通过政策引导,以产教融合为主线,构建稳定的适合地方应用型高校办学实际的专业人才培养体系。     

高分子专业开展“同期、分散”毕业实习的探索与实践

近二十年来,受到专业调整和国企改革等的影响,愿意且有能力成建制地接受整个专业的学生驻厂开展为期一个月左右毕业实习的企业极少,使得毕业实习成为诸多高校开展实践教学的一个难点。本文以华南理工大学高分子材料与工程专业近年来以"同期、分散"的形式探索开展本科毕业实习为例,从本科教学实习基地建设、校外导师聘任、实习管理以及实习效果评价等角度,简要介绍了在工程教育专业认证背景下,在毕业实习的教学组织和开展过程中的一些探索和心得。     

基于“两制四化”人才培养模式的本科生生产实习的改革实践

结合浙江工业大学本科生生产实习的现状,首先论述了目前本科生生产实习存在的问题,并以浙江工业大学材料科学与工程学院为试点,提出了以"两制四化"人才培养模式为多元化内容的生产实习实践形式。改革与实践的具体内容涉及:在以书院制为构建框架、以"导师制"为举措,建立与专业特色相契合的生产实习基地的基础上,以小班化的单位、根据个性化的生产实习要求,结合复合化与国际化的改革思路,建立的新型生产实习模式以及学生管理模式和评分模式的改革。经过3年的探索和实践表明,本科生生产实习改革的实施,取得了很好的效果。     

教育实习经历对化学职前教师PCKg发展的影响——以高中化学实习教师的个案研究为例

基于学科教学识知PCKg理论,以一位化学职前教师(即高等师范院校的化学教育硕士)为个案,在长达5个月的研究期中,藉由教学观察、教案文件、导师访谈以及量表问卷等方式收集资料,探讨个案职前教师在实习历程中PCKg的建构与发展情形,及高中教学现场和师资培育高校的协助对实习教师的教学专业成长的影响,并建构“师培高校与中学现场协同培育以促进职前教师专业成长”的实习模式。研究结果可为未来规划师资培育工作及职前教师实习制度提供案例参考和研究建议。     

南开大学在离子交换与吸附科学技术领域的部分成果简介

在何炳林教授指导下,经过三十多年的发展,南开大学在离子交换树脂与吸附树脂的研究与生产方面,已形成了一个完整的体系。该校高分子化学研究所,化学系,高分子化学研究所所办化工厂,生物系,分子生物研究所和校测试分析中心密切配合,并与全国各地的有关单位进行协作,在新树脂的研制与生产,树脂性能的测试、树脂的应用和基础理论研究诸方面,取得了一系列重要的科研成果,尤其是吸附树脂的研究,已达到国际先进水平。我们选取了该校在这一领域中的部分科技成果作简略介绍,以飧读者。     

地方高校应用型人才培养模式改革与创新的探索与实践

探索、深化人才培养模式成为地方高校日益关注和重视的问题。以重庆第二师范学院应用化学专业（化工制药与药物分析检测方向）为例,分别从人才培养方案的制定、教学模式的探索、课程改革的实施和条件保障等4个方面加以分析和讨论,阐述地方本科院校在推进应用型人才培养方面的经验和途径。结果表明,针对地方应用型本科高校的功能定位,人才培养模式应该更加注重与当地企业的密切联系,努力满足行业对于化学制药与分析检测人才的要求。     

地方高校一流化学专业建设的系统设计与实践

郑州大学化学专业具有悠久的办学历史和优良的办学传统,面对新高考模式对化学专业选材的冲击和拔尖学生培养的新挑战,郑州大学化学学院在人才培养模式方面进行了一系列探索和实践,找到了一条适合地方高校一流专业建设与发展的道路。     

我校高分子材料与工程专业生产实习的改革与实践

高分子材料与工程专业的生产实习是本专业重要的教学环节,对于培养学生的实践能力与综合素质具有重要作用,针对目前我校生产实习中存在的问题,引入多媒体仿真实习,从单元训练入手,逐步过渡到大型聚合反应装置,将原来的单一到工厂生产实习的模式改革为数字化仿真实习和工厂实际生产实习相结合的模式,积极联系多家生产实习企业,多方位多角度拓宽实习渠道,并严格考试制度,严把考核关。经过几年的改革与实践,我校生产实习取得了较好的实习效果。     

高分子专业毕业实习现状分析及措施研究

针对高分子材料科学与工程专业毕业实习存在的问题,结合国际工程认证要求以及学校对毕业生要求达到的毕业目标,提出了高分子专业毕业实习适合采取集中实习和分散实习相结合的方法。让毕业实习融入到毕业设计及毕业论文中,并使实习成为提前毕业设计和论文、就业、自谋出路的一部分,建立稳定的校外实习基地,提高学生毕业实习的质量,在巩固和深化他们自身专业理论水平的同时,提高其动手创造能力和思维创新能力,并使其综合工程素质得到提高。     

高分子材料与工程专业生产实习环节的教学改革与实践

本文结合高分子材料与工程专业教学实践,分析了生产实习教学实际情况及存在的问题,对生产实习课程进行改革,提出了校外实习与校内实习协同进行的新生产实习模式,重点建设校内生产实习内容体系,切实解决校外实习内容更新慢,缺乏前沿成型技术这一问题。校内实习基地的建设结合了制度保障体系、教师队伍和信息化平台建设等进行了深入实践,学生参与生产实习的热情提高明显,各项创新创业大赛、考研和就业情况表明,本专业学生具有较好的工程实践和创新能力,改革实施效果明显。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.