共查询到20条相似文献,搜索用时 768 毫秒
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《化学通报》2005,68(7):558-560,546
[w074]环氧化合物的不对称开环反应AsymmetricRingOpeningofEpoxides王朝阳(西南交通大学药学院四川峨眉614202)介绍了在不同手性配体和路易斯酸的催化下内消旋环氧化合物的不对称开环反应与外消旋末端环氧化合物的水解动力学拆分与开环反应;并指出了环氧化合物的这两种反应在不对称合成与手性药物领域的应用价值以及在工业上广阔的应用前景。Progressesinasymmetricringopening(ARO)ofmesoepoxideswithdifferentchiralligand,andthehydrolytickinetic resolution(HKR)ofracemicterminalepoxidescatalyzedbychiralSalenmetalcomplexwer… 相似文献
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1,1,3,3-四(全氟己基乙基)二锡氧烷二聚体在环氧化合物开环反应中的催化作用 总被引:2,自引:0,他引:2
采用氟碳-有机溶剂两相催化体系,考察了1,1,3,3-四(全氟己基乙基)二锡氧烷二聚体(1)在环氧化合物开环反应中的催化作用.结果表明,催化剂(1)在氟碳-有机溶剂两相体系中使环氧苯乙烯和甲醇的开环反应产率高达95%,13CNMR谱表明,开环反应的区域选择性为100%.在氟碳-有机溶剂两相催化体系中以一锅法制备了3-苯基丙酸2-甲氧基-2-苯乙醇酯,收率高,方法简便,催化剂几乎可以定量回收循环使用. 相似文献
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以右旋肌醇甲醚为原料,经保护的甲烷磺酸酯与腺嘌呤缩合,合成了腺嘌呤核苷类似物5.此外,化合物3经酸水解,再经环氧化高产率地合成了重要的中间体7,腺嘌呤在强有机碱存在下,对环氧化合物7进行区域性的开环反应,合成了另外两种腺嘌呤核苷类似物8和9. 相似文献
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作为有机强碱,胍类化合物可用于催化多种反应[1 5],并且反应可以在均相、无水条件下进行,不需要相转移催化剂。本文探讨用胍催化邻苯二甲酰亚胺对环氧化合物进行开环。用三光气将二乙胺转变为四乙基脲1,后者用五氯化磷和叔丁胺处理得到1,1,3,3 四乙基 2 叔丁基胍2。用2催化邻苯二甲酰亚胺与末端环氧化合物的反应,实现了环氧化合物的区域选择性开环。合成路线如下:1 实验部分1 1仪器与试剂WC 1型显微熔点仪(四川大学科仪厂),温度计未校正;Carlo ErbaModel1110自动元素分析仪,Varian400MHz核磁共振仪。溶剂和试剂经干燥、重蒸后使用… 相似文献
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Melamine sulfonic acid as a novel and efficient solid acid catalyst has been synthesized and used in the ring opening of epoxides under solvent-free conditions. This catalyst afforded the corresponding thiocyanohydrins with good regioselectivity and very short reaction times. The catalyst can be easily separated and reused several times without appreciable loss of activity. The availability and recoverability of the catalyst with easy operation and workup make this method attractive for organic synthesis. 相似文献
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《Arabian Journal of Chemistry》2020,13(11):8200-8208
β-Hydroxynitriles are essential intermediates in the synthesis of diverse bioactive compounds and clinical drugs. One of the precursor reactions to these intermediates is the opening of an epoxide ring with a cyanide nucleophile. In the present study, we report a milder and safer route to β-hydroxynitriles employing recyclable, Amberlyst A-21 resin in the ring-opening of epoxides with acetone cyanohydrin in water. A diverse range of substrates (fifteen), including aromatic epoxides, phenoxy epoxides, non-terminal, and terminal aliphatic epoxides, are investigated under the optimized conditions to afford the desired β-hydroxynitriles in good to excellent yield. In addition to this, the recyclability of the Amberlyst A-21 resin is also successfully demonstrated. This relatively safer methodology has the potential to be explored in other organic transformations. 相似文献
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Recent progress on the synthesis of organic carbonates by halogen-free processes has been reviewed. With CO2 as a cheap and non-toxic feedstock, alcohols, epoxides and olefins can convert to abundant organic carbonates, e.g. dialkyl carbonates, five- or six-membered cyclic carbonates and polycarbonates. To avoid environmental pollution and equipment corrosion, new synthesis routes which exclude traditional halogen-containing catalysts and solvents have caused much attention. Effective alternatives mainly include the organic/inorganic bases and metal-complexes catalysts. In addition, novel carriers for the catalysts are being applied in these processes to improve the activity and facilitate the recovery. 相似文献
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Smith AB Pitram SM Boldi AM Gaunt MJ Sfouggatakis C Moser WH 《Journal of the American Chemical Society》2003,125(47):14435-14445
The development, application, and advantages of a one-flask multicomponent dithiane linchpin coupling protocol, over the more conventional stepwise addition of dithiane anions to electrophiles leading to the rapid, efficient, and stereocontrolled assembly of highly functionalized intermediates for complex molecule synthesis, are described. Competent electrophiles include terminal epoxides, epichlorohydrin, and vinyl epoxides. High chemoselectivity can be achieved with epichlorohydrin and vinyl epoxides. For vinyl epoxides, the steric nature of the dithiane anion is critical; sterically unencumbered dithiane anions afford S(N)2 adducts, whereas encumbered anions lead primarily to SN2' adducts. Mechanistic studies demonstrate that the SN2' process occurs via syn addition to the vinyl epoxide. Integration of the multicomponent tactic with epichlorohydrin and vinyl epoxides permits the higher-order union of four and five components. 相似文献
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Research on Chemical Intermediates - The rapid method for the synthesis of organic azides was achieved by employing azide acceptors such as halides, epoxides and pseudohalides like diazonium salts... 相似文献
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《化学:亚洲杂志》2017,12(10):1095-1103
The synthesis of solid catalysts for the co‐catalyst‐free cycloaddition of CO2 has attracted much attention. Herein, we report a hierarchical porous organic polymer, Py‐Zn@MA, that is able to catalyze the cycloaddition reaction of epoxides and CO2 without using any additives or co‐catalyst to afford turnover frequency (TOF) values as high as 250 and 97 h−1 at 130 °C by using pure and diluted CO2 (simulating flue gas), respectively. These results are superior to those obtained from previously reported heterogeneous co‐catalyst‐free systems. The high activity of Py‐Zn@MA is mainly attributed to its bifunctional nature with ZnBr2 and pyridine activating the epoxide in a cooperative way. Notably, Py‐Zn@MA can be easily prepared on a large scale without using any catalyst and the chemicals are cost effective. Moreover, Py‐Zn@MA shows good substrate universality for the cycloaddition reactions of epoxides. Our designed porous organic polymer Py‐Zn@MA material has the potential to serve as an efficient catalyst for the direct conversion of flue gas with epoxides into value‐added cyclic carbonates. 相似文献
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绿色路易斯酸三卤化铟在有机合成中的应用 总被引:1,自引:0,他引:1
三卤化铟作为温和的路易斯酸可在水、醇等绿色溶剂中实现高化学选择性、高 区域选择性和高立体选择性的化学转化。综述了三卤化铟在羟醛反应和类羟醛-曼 尼希反应、Fiedel-Crafts反应、环氧化合物的重排反应、α-氨基膦酸的合成、喹 啉环系的构建、酯交换反应、Diels-Alder反应和杂Diels-Alder反应,手性呋喃二 醇的合成、水相中的叠氮解反应和二硫缩醛的制备中的应用,同时还总结了本课题 组将三卤化铟应用于Biginelli反应和还原脱氧反应的反应结果。三卤化铟在有机 合成中潜在的优势将推动“绿色化学”的发展。 相似文献
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锌和锡参与下末端环氧化物的选择性烯丙基化反应 总被引:1,自引:0,他引:1
烯丙基溴和金属辛或锡成功地将末端环氧化合物1一锅法合成高烯丙基醇2和双高烯丙基醇3. 还研究了环氧化合物取代基的影响, 并提出了此烯丙基化的反应途径 . 相似文献