共查询到20条相似文献,搜索用时 250 毫秒
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以壳聚糖为载体制备了负载型L-脯氨酸不对称催化剂;将合成产物用于催化丙酮与取代苯甲醛在水中的直接不对称Aldol反应,考察了其催化性能.结果表明,与在有机溶剂中的L-脯氨酸催化剂相比,在水相中的壳聚糖负载L-脯氨酸催化剂表现出更好的催化活性;就间硝基苯甲醛与丙酮在水中的不对称Aldol反应而言,壳聚糖负载L-脯氨酸催化下的产率和ee值分别达95%和48%.此外,壳聚糖负载L-脯氨酸催化剂在水中具有很好的重复使用性能,重复使用10次后相应的产率和ee值分别为88%和68%. 相似文献
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在温和条件下制备了L-脯氨酸稳定并修饰的负载型金属铱催化剂,用于苯乙酮及其衍生物不对称催化加氢反应. 考察了L-脯氨酸的量、溶剂、碱以及碱的量和氢气压力对苯乙酮不对称催化加氢反应的影响. 结果显示,该催化剂催化苯乙酮不对称加氢反应获得了92.1%的转化率和32.9%的对映选择性(e.e.),催化2′-(三氟甲基)苯乙醇的对映选择性为39.3,这一结果高于目前报道的天然手性修饰剂修饰的负载型金属催化剂. 该催化循环使用5次, 对映选择性只有小幅度下降. 相似文献
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Aldol condensation of acetophenone and benzaldehyde, as well as various benzaldehydes was carried out efficiently to produce chalcone with a good selectivity and high yields by using modified CaO as a solid base catalyst. Stability and catalytic activity of commercial CaO were significantly improved after modifying calcium oxide with bromobenzene in a simple way. An Aldol yield higher than 98.9% was obtained after the reaction was conducted for 3 h. This time interval is considerably shorter when compared to a period of 12 h needed for the commercial CaO to reach 92.1% yield under optimum activation. The high catalytic activity of modified CaO suggests that heterogeneous aldolisation was greatly improved by changing its hydrophilic properties. The influence of several reaction parameters, such as temperature and catalyst loading, was investigated. The humidity test over modified CaO reveals that the basic sites of modified CaO are resistant to CO2 and moisture. The type of aldehyde has great influence on the yield of Aldol condensation. Based on the results of characterization by Fourier transform-infrared spectrometry (FT-IR) and thermogravimetric measurements (TG), it was concluded that the modifier was chemically bonded to the surface of CaO and nearly no Ca(OH)2 was formed during the modification process. 相似文献
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Tang Z Yang ZH Chen XH Cun LF Mi AQ Jiang YZ Gong LZ 《Journal of the American Chemical Society》2005,127(25):9285-9289
L-proline amides derived from various chiral beta-amino alcohols that bear substituents with various electron natures at their stereogenic centers are prepared and evaluated for catalyzing the direct Aldol reaction of 4-nitrobenzaldehyde with acetone. Catalysts with strong electron-withdrawing groups are found to exhibit higher catalytic activity and enantioselectivity than their analogues with electron-donating groups. The presence of 2 mol % catalyst 4g significantly catalyzes the direct Aldol reactions of a wide range of aldehydes with acetone and butanone, to give the beta-hydroxy ketones with very high enantioselectivities ranging from 96% to >99% ee. High diastereoselectivity of 95/5 was observed for the anti Aldol product from the reaction of cyclohexanone, and excellent enantioselectivity of 93% ee was provided for anti Aldol product from the reaction of cyclopentanone. 相似文献
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F. Guillier F. Nivoliers A. Godard F. Marsais G. Quguiner 《Journal of heterocyclic chemistry》1999,36(5):1157-1165
A methodical investigation on functionalization by carbonylated groups in position 4 and 5 of the benzo[c][2,7]naphthyridine skeleton has been undertaken. In particular the study has shown the complex influence of these two sites on each other. A careful choice of both substituents in 4 and 5 permitted the synthesis of an interesting pyrido[2,3,4-kl]acridone tetracyclic structure through an intramolecular Mukayama aldolisation reaction. The structure is supposed to be a potential precursor to various marine alkaloids of the pyridoacridine family. 相似文献
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Esterase BioH,which is obligatory for biotin synthesis in Escherichia coli,was found to exhibit a promiscuous ability to catalyse Aldol and Knoevenagel reactions with moderate to good yields.The reaction conditions including organic solvent,molar ratio of ketone to aldehyde,enzyme amount,and reaction time were investigated to evaluate the effect of different reaction conditions on yield.Target compounds were afforded in the best yield of 91.2% for Aldol reaction and 54.7% for Knoevenagel reaction.In addition,because the enzyme could be prepared with a low cost,this protocol could provide an economic route to conduct Aldol and Knoevenagel reactions,which expand the field of enzymatic promiscuity. 相似文献
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The structure of waol A has been revised from 1 to 6, the vinylogue of TAN-2483A (5). Aldol reaction of hydroxybutanolides 13b,c with 2,4-hexadienal affords 12b,c, which are subjected to iodoetherification with bis(sym-collidine)IPF6 to provide 11b(c). Treatment with Et3N in CH2Cl2 completes the three-step syntheses of TAN-2483A (5) and waol A (6). Aldol reaction of hydroxybutanolide 31 with 2,4-hexadienal affords 32, which is subjected to iodoetherification to provide 34, which in turn is treated with Bu3SnCl, NaBH3CN, and oxygen to provide diol 60. Further elaboration completes the first syntheses of massarilactone B (7) and the fusidilactone B (9) ring system. 相似文献
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本文研究了以(S) -N-取代-1,2,3,4-四氢异喹啉-3-甲酰胺衍生物的有机小分子催化剂催化不对称Aldol反应,得到高达92%收率和57%的ee值. 相似文献
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Dongyue Zhang Chonglei Ren Wantai Yang Jianping Deng 《Macromolecular rapid communications》2012,33(8):652-657
This Communication reports optically active helical substituted polyacetylenes which solely catalyzed asymmetric Aldol reaction between cyclohexanone and p‐nitrobenzaldehyde; more importantly the helical structures are found to play crucial roles in the asymmetric catalysis, with a remarkable yield and ee (both up to 80%). A synergic effect is observed between the helical structures in the polymer main chains and the pendent prolinamide moieties for successfully catalyzing the asymmetric reaction. The role of the helical polymer backbones is further verified by tuning the relative helical structure content. 相似文献
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Ghodsi Mohammadi Ziarani Parisa Gholamzadeh Alireza Badiei Vaezeh Fathi Vavsari 《Research on Chemical Intermediates》2018,44(1):277-288
Pyruvic acid contains three different reactive positions: –COOH, ketone carbonyl and methyl groups. Correspondingly, pyruvic acid was applied as starting material in the modified Niementowski reaction and Aldol condensation using SBA-Pr-SO3H as an efficient nanocatalyst. Aldol condensation of pyruvic acid and oxindole provided a new oxindol-based carboxylic acid which was subsequently used in the Ugi four-component reaction. Moreover, through the modified Niementowski reaction of pyruvic acid, new derivatives of quiazoline were produced in the presence of SBA-Pr-SO3H. The obtained products are important due to their potentially biological active skeletons. 相似文献