| (S)-N-取代-1,2,3,4-四氢异喹啉-3-甲酰胺催化直接不对称Aldol反应研究 |
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| 引用本文： | 李松立,杨健国.(S)-N-取代-1,2,3,4-四氢异喹啉-3-甲酰胺催化直接不对称Aldol反应研究[J].化学研究与应用,2011,23(5):573-577. |
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| 作者姓名： | 李松立 杨健国 |
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| 作者单位： | 1. 台州学院医药化工学院,浙江,台州,317000;山西潞安煤基合成油有限公司,山西,长治,046032
2. 台州学院医药化工学院,浙江,台州,317000 |
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| 基金项目： | 浙江省自然科学基金(Y406049)资助项目; 浙江省高校学生科技创新(新苗人才计划)(2008R40G2170052)资助项目 |
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| 摘 要： | 本文研究了以(S) -N-取代-1,2,3,4-四氢异喹啉-3-甲酰胺衍生物的有机小分子催化剂催化不对称Aldol反应,得到高达92%收率和57%的ee值.
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| 关 键 词： | 1 2 3 4-四氢异喹啉 有机小分子催化剂 Aldol反应 |
Asymmetric direct Aldol reactions catlyzed by(S)-N-substituted-1,2,3,4-tetrahydroisoquinoine-3-carboxamide |
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| LI Song-li,YANG Jian-guo.Asymmetric direct Aldol reactions catlyzed by(S)-N-substituted-1,2,3,4-tetrahydroisoquinoine-3-carboxamide[J].Chemical Research and Application,2011,23(5):573-577. |
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| Authors: | LI Song-li YANG Jian-guo |
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| Institution: | LI Song-li 1,2,YANG Jian-guo 1 (1.School of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou 317000,China,2.Shan'xi Lu'an Coal-based synfuel Co.Ltd,Changzhi 046032,China) |
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| Abstract: | A novel class of(S)-N-substituted-1,2,3,4-tetrahydroisoquinoine-3-carboxamide derivatives had been synthesized and evaluated in the direct Aldol reaction of aromatic aldehyde with ketone.The reaction generated the desired Aldol products in high yields(up to 92%) and moderate stereoselectivities(up to 57% ee) at room temperature. |
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| Keywords: | 1 2 3 4-tetrahydroisoquinoine organocatalyst Aldol reaction |
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