Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2‐[(4‐nitro‐3‐methylpyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole and 2‐[(4‐chloro‐3‐methyl‐pyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole, were prepared in several ways. 相似文献
1,6-Dihydro-3-hydrozinocarbonyl-6-pyridazinone (compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate. A series of N-aryl-2-(1‘,6‘-dihydro-6‘-pyridazinone-3‘-carbonyl) thiosemicarbazides 3a-3f were synthesized from the reaction of aryl isothiocyanates with compound 2. The terminal compounds 1,3, 4-thiadiazole, 1,3,4-oxadiazole and 1,2, 4-triazol-5-thione derivatives were cyclized from compounds 3a-3f. Their structures were confirmed by IR,^1H NMR, MS and elemental analyses. 相似文献
Extraction mechanism and solvent structure were studied for the solvent extraction of cationic porphyrin (5,10,15,20-tetrakis(l-methyl-pyridinium-4-yl) porphyrin; H2(tmpyp)4+, and its metalloporphyrins (MP(n+2)+-) into an acetonitrile phase separated from a 1:1 (v/v) mixture of acetonitrile with water by addition of sodium chloride, where Mn+ denotes Zn2+, Cu2+,Co3+, Fe3+, and Mn3+, and H2P4+ is the free base form of H2tmpyp4+. The separated acetonitrile phase contains a lot of water (4.53 mol dm-3) and sodium chloride (2.49×10-2 mol dm-3) that afford to extract the highly charged chemical species of the above porphyrin or metalloporphyrins with perchlorate ion (X-). The extracted chemical species dissociate in the acetonitrile phase. 相似文献
New ferroelectric liquid crystals containing two chiral centers, 4-(4′-n-alkyloxyphenyl)phenyl 4-{2(S)-[2(S)-methylbutyloxy]propoxy}benzoate ( 4a-4f ) and 4 -(n-alkyloxy)phenyl 4-{4′-[2(S)-(2(S)-methylbutyloxy)propoxy]phenyl}benzoate ( 5a-5f ) were synthesized and their physical properties studied. A phase-transition sequence of C-Sc*-N*-I was observed in most cases. Some homologues of them, 4a-4d , possess monotropic Sc * phase. Not only the Sc* phase-transition temperature of 5a-5f is lower than that of the corresponding 4a-4f , but their Sc * phase-transition temperature range is also wider than the corresponding 4a-4f . The Sc * phase temperature range can be up to 48 °C. The spontaneous polarization of 8-28 nC/cm2 and the electric rise time of 240-420 μs were measured in FLCs 4a-5f . 相似文献
A series of novel 6,7,8,9‐tetrahydro‐2‐(2‐aryloxypyrimidin‐4‐yl)‐2H‐[1,2,4]triazolo[4,3‐a]azepin‐3(5H)‐ones were designed and efficiently synthesized. Their structures were determined by IR, 13C and 1H NMR, mass spectroscopy, and elemental analysis. These compounds were screened for herbicidal activities against rape and barnyard grass. Compounds 5a‐5f and 5m exhibited moderate herbicidal activity against rape. In addition, the synthesis of the intermediate 1‐(azepan‐2‐ylidene)‐2‐(2‐chloropyrimidin‐4‐yl)‐hydrazine ( 3 ) was studied and the reason for the low yield in the initial procedure is discussed as well. 相似文献
Surface‐modified Fe 3 O 4 nanoparticles (NPs) can be obtained by substituting [(η5‐semiquinone)Mn(CO)3] for oleylamine surface protecting groups. The resulting NP can function as a nucleus or template to generate crystalline coordination polymers that contain superparamagnetic Fe3O4 NPs. Hybridized magnetic properties can be obtained by introducing paramagnetic metal nodes, such as Mn2+, into the polymers (see picture).
The functionalization of zinc oxide (ZnO) nanoparticles by poly(3‐hexylthiophene) (P3HT) brush is completed by the combination of a mussel inspired biomimetic anchoring group and Huisgen cyclo‐addition “click chemistry.” Herein, the direct coupling of an azide modified catechol derivative with an alkyne end‐functionalized P3HT is described. This macromolecular binding agent is used to access core@corona ZnO@P3HT with a stable and homogeneous conjugated organic corona. Preliminary photoluminescence measurement proves an efficient electron transfer from the donor P3HT to the acceptor ZnO nanoparticles upon grafting, thus demonstrating the potential of such a combination in organic electronics.
