基于问题的教学法在药物化学教学中的应用

药物化学是药学专业和制药工程专业的必修课。为提高教学质量,尝试将基于问题的教学法（PBL）应用于药物化学教学中,构建以学生为中心、发展自主学习的技能的相关教学模式,创设了适合于学生主动参与的新型教学环境,并对相应具体操作模式进行探讨。初步提出了一些评价方法,对于提高师生的教学兴趣,考察PBL教学效果具有指导意义。     

从PBL教学方法谈医学检验专业本科分析化学教学改革

作为医学检验专业分析化学教师 ,不仅要使医学检验专业的学生掌握分析化学的基本理论和应用 ,还要使学生的综合能力通过学习分析化学得到锻炼和提高 ,为分析化学和临床检验的发展培养合格人才。因此 ,深化大学阶段分析化学教学改革 ,提高分析化学教学质量刻不容缓。下面从 3个方面谈谈PBL教学方法与分析化学教学改革。1　PBL教学法及其意义　　PBL即Problem BasedLearning的缩写 ,中文译为“以问题为基础的教学法”。该方法由美国神经病学教授Barrows创立 ,与传统教学法的根本区别在于 :前者强调以学生的主动学习为主 ,在干中学 ,学生…     

PBL与LBL结合的教学模式在工科有机化学教学中的应用

分析了以问题为中心的教学模式的优缺点,提出了PBL(Problem-based Learning)教学与LBL(Lecture-based Learning)教学相结合的模式,并在制药工程专业及化学工程与工艺专业的有机化学教学中尝试开展了PBL与LBL相结合的教学模式,实践表明该教学模式有助于增强有机化学教学效果,提高教学质量。该教学模式可以在工科学生的有机化学教学中进行推广应用。     

结合PBL课例的无机化学线下对分课堂教学设计与实践*

以原电池一节教学设计为例,探索了将PBL课例融入对分课堂教学模式。教学实践表明,新教学模式激发了学生的学习兴趣,提高了学生学习的积极性和主动性,提升了课程教学效果,达到了课程教学目标。对PBL课例与对分课堂有机融合的全新课堂教学模式的建设与发展进行了展望。     

药学专业留学生分析化学实验全英文教学的体会

留学生教育已成为我国高等教育的重要组成部分,而全英文教学是无中文基础的留学生的最佳选择。分析化学实验为药学专业本科生的必修课,本文针对药学专业留学生分析化学实验课的全英文教学过程,从课程的教学安排、教材选用、教学师资、授课方式和考评方式等方面讲述了教学实践中的体会,希望为开设同类课程的全英文教学提供借鉴和参考。     

“工业分析”课程中PBL与LBL相结合的教学探讨

根据应用化学的专业特点,在"工业分析"课程中进行PBL与LBL相结合的教学探讨。通过对PBL教学模式的实施过程、应用效果、实施前提以及存在问题的论述分析,提出对综合性较强的学科采用PBL与LBL相结合教学法的必要性。特别是对学习独立性与自主性较强的高年级学生,PBL与LBL相结合的教学法在提高学生学习兴趣,增强学生分析问题的能力等方面具有一定的优势,有利于"工业分析"课堂教学质量的提高。     

基于微课的翻转课堂教学模式在分析化学实验教学中的探索

分析化学实验是大学化学实验的重要内容,是分析化学课程学习中不可缺少的组成部分。为了提高分析化学实验教学质量,提升学生动手能力、分析问题和解决问题的能力以及创新能力,解决传统教学模式存在的主要问题,对分析化学实验教学模式进行了改革探索。将以微课为基础的翻转课堂教学模式引入到分析化学实验中,激发学生的实验热情,提高学生综合实验技能,巩固基础理论知识,培养了科学研究思维,真正实现创新性人才培养目标。     

转动课堂在分析化学教学中的应用

"转动课堂"是渤海大学依据地方综合性大学的人才培养目标,借鉴国内外的课堂教学模式引申而来,将课堂精讲与师生互动紧密结合,个性化培养学生的创新能力和动手能力。本文介绍了分析化学结合学科特点及转动课堂核心理念,设计自学、精讲、互动等8个教学环节以提高课堂效率。这种课内课外协同互补的教学模式,激发了学生学习分析化学课程的热情,课堂教学质量及学生学习效果明显提高。     

雨课堂在分析化学教学中的应用

分析化学是一门理论性和应用性都很强的基础学科，为了进一步提高学生的学习兴趣，培养学生分析问题和解决问题的能力，加强师生之间的互动，尝试把雨课堂的线上线下教学模式应用到课程教学过程中。实践证明，运用雨课堂教学，学生学习的积极性和考试成绩都得到了明显的改善，极大程度上推动了分析化学教学改革的发展。     

基于CDIO模式的分析化学课程改革

在CDIO工程教学模式指导下,改进分析化学课程教学方法和手段,以提升应用型人才培养水平。通过分解课程知识层次,建立基础知识和基本技能的课程标准,设计训练项目和综合应用的一体化课程计划,实施有效的评估机制,加强了学生的专业意识和学习目的性,调动了学生的学习积极性和团队合作精神,促进了教师教学实践能力的提高。基于CDIO模式的分析化学课程改革,能更好地服务专业课程建设,切实提高教学效率和质量。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.