β-环糊精增敏荧光光谱法对柔红霉素的定量测定

采用荧光光谱法对β-环糊精（β-CD）与柔红霉素（DNR）包结物溶液进行表征。研究了β-CD与DNR之间的超分子包结作用机理,讨论了时间、温度和β-CD浓度对包结反应的影响,建立了新的定量检测微量DNR的方法。研究结果表明,DNR本身具有天然荧光,与β-CD形成1：1的超分子包结络合物后,荧光强度增大,β-CD对DNR有较强的荧光增敏作用。在25℃,pH7.0时,包结常数K=1.26×106L/mol。β-CD增敏荧光定量测定DNR的线性回归方程为y=1.78×107x＋312.76,相关系数为r=0.9953,检测下限为3.77×10-6mol/L。     

β-环糊精与阿霉素表面包络作用的电化学研究

研究了阿霉素（ADM）在β-环糊精（β-CD）修饰金电极上（β-CD/Au）的电化学行为.结果表明,ADM在β-CD/Au电极上发生表面包络反应.25℃,pH=7.0时,该电极表面包络常数为9.54×104 L·mol^-1,并随温度呈规律性变化,最适宜反应温度为30℃.该电极ADM包络呈准可逆的电化学反应,速率常数为...     

基于透明质酸的刺激响应纳米给药系统的研究进展

透明质酸(Hyaluronic acid, HA)是一种天然多糖,具有良好的生物相容性和生物降解性,利用 HA 构建的纳米载体自身就具有肿瘤靶向功能,可以作为抗癌药物载体将药物传递到肿瘤细胞内从而实现精准到达病患处。近年来透明质酸在应用于肿瘤靶向给药系统中的关注越来越多,成为了靶向治疗肿瘤的一大研究热点。基于透明质酸的基本特性和肿瘤靶向的生理学基础,在不同的刺激响应下,透明质酸型纳米给药系统能将药物集中释放于肿瘤的微环境内,更好地杀死肿瘤细胞,同时避免其他正常的组织受到药物损害。本文主要综述了透明质酸型纳米药物输送系统在各种刺激响应下释放药物的最新研究进展。     

SHER-HIAF ring lattice design

The Super Heavy Experimental Ring (SHER), which is one of the rings of the next accelerator complex High Intensity Heavy Ion Accelerator Facility (HIAF) at IMP, has to be optimized for e-cooling. Its lattice is designed for two modes: the first is the isochronous mode, which is a time-of-flight mass spectrometer for short-lived secondary nuclei, the second is the storage ring mode, which is used for collecting and cooling the secondary rare isotope beams from the transport line. In order to fulfil its purpose, the ion optics can be set to different ion optical modes.     

HIAF中环形质量谱仪SRing的线性设计

为了精确测量短寿命原子核质量,提出了在强流重离子加速器装置(HIAF)上建造高精度环形质量谱仪SRing。SRing长188.7 m,最大设计磁刚度为1 3 T·m,主要由磁聚焦结构、注入系统、引出系统、随机冷却以及探测系统等组成。SRing将运行在等时性模式和收集模式下用于短寿命原子核质量的精确测量和放射性次级束流收集并纯化。详细介绍了SRing的线性光学设计,并给出两种模式下的光学设计、注入及引出系统的设计等,设计参数优化完毕后,机器测量精度有望提高到10~6。     

300 MeV质子重离子同步加速器慢引出动力学研究

300 MeV质子重离子同步加速器是SESRI(空间环境模拟研究装置)的重要组成部分，慢引出系统动力学研究是该同步环设计的关键。引出系统采用三阶共振慢引出与RF-Knockout(RF-KO)方案为终端提供2～8 s准连续束，在引出静电偏转板处利用3-bump局部凸轨可适当调节螺距和引出角度，但同时也会减小水平工作点，缩小相空间稳定区面积，影响束流正常引出。模拟结果表明，凸轨内二极磁铁和六极磁铁会引起水平工作点减小，造成引出初始阶段粒子大量溢出。因此，基于自主编写的粒子追踪程序SESP对束流时间结构进行了分析，并通过优化激励调幅曲线改善了束流时间结构的均匀性。     

IH型漂移管直线加速器的束流动力学研究（英文）

为了提高兰州重离子加速器冷却储存环（HIRFL-CSR）的运行效率、改善加速器输出束流品质,并实现几个加速装置分时供束,提高整个重离子加速装置的利用率,特为（HIRFL-CSR）增建一台新的注入器--CSRLINAC。在108.48 MHz的RFQ之后的CSR-LINAC主加速段,主要由一台108.48 MHz和两台216.96 MHz的IH型漂移管直线加速器组成,用于加速荷质比为1/8.5~1/3之间的重离子,其最大的束流流强为3 mA,并将粒子从0.3 MeV/u加速到3.71 MeV/u。运用KONUS动力学原理,在满足设计指标的情况下,首先利用TraceWin程序进行中能束线MEBT设计,后针对高频腔体设计和束流匹配的基本参数的系列讨论,特别是对CSR-LINAC的中能束流匹配线、参数选择和IH型KONUS结构的漂移管直线加速器进行设计模拟优化。最终得出,在保证腔体设计指标和95.3%的传输效率的情况下,该紧凑型直线加速结构经过三个腔体的加速后,束流的纵向归一化均方根发射度增长仅有25%;同时发现,当流强达到3 mA时,存在空间电荷效应,导致其纵向相宽增长约25%,最大横向包络也存在16.5%的涨落。In order to improve the operation efficiency of the Cooling Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR), a heavy ion linac (linear accelerator) was proposed and designed as a new injector for HIRFL-CSR. Following the 108.48 MHz Radio-Frequency Quadrupole (RFQ), three tanks in total with Interdigital H-mode drift tube linac (IH-DTL) structure are installed to boost the beam energy from 0.3 to 3.71 MeV/u, and the beam current of ions with charge-to-mass ratio from 1/8.5 to 1/3 can reach to 3 mA. The first tank operatesat the same frequency as the RFQ, and the rest two operate at 216.96 MHz. The “Combined Zero-Degree Synchronous Particle Structure” (KONUS) beam dynamics was used in the beam dynamics design. The overview of the physics design on the main accelerating components, including RF design and beam dynamics design are introduced in this paper. The optimized structure design, fabrication status and simulation results are presented in this contribution. It shows that under the condition of assurance of 95.3% transmission efficiency, the normalized rms emittance is about 25%. When the beam current is up to 3 mA, owing to the space charge effect, the increase of longitudinal phase spread and transverse envelope are about 25% and 16.3%, respectively.     

高速水面舰船型线的数学模型

提出了一种应用数学模型构建高速水面舰船船型的设计方法.该"数学船型"方法根据舰船的应用特性确定船型曲线的几何性质及应满足的定解条件,应用定解条件确定船型曲线的形状函数或型值函数,从而生成所需船型曲面.实验表明,"数学船型"方法无需型值即可得出设计舰船的型值表、型线图和任意视向的立体船图,且能保证船体的浮性、稳性和具有最小阻力等重要性能.方法可用于舰船设计的初始阶段,在与"数学船池"连接后,易于对船型做优化设计.     

具有可见光响应的C、N共掺杂TiO2纳米管光催化剂的制备

为了提高二氧化钛对可见光的利用效率, 采用等离子体电解方法对二氧化钛实现了C、N共掺杂. 掺杂通过等离子体电解HCONH2、NaNO2、(NH2)2CO产生活性N、C实现. XPS结果表明, C、N掺杂进入了氧化钛晶格. 紫外漫反射光谱分析表明, 氧化钛对可见光(>400 nm)的响应增强, 其光催化降解能力也大大增强. C、N共掺杂TiO2是一种利用太阳能的理想的光催化剂.     

SHER-HIAF ring lattice design

The Super Heavy Experimental Ring （SHER）, which is one of the rings of the next accelerator complex High Intensity Heavy Ion Accelerator Facility （HIAF） at IMP, has to be optimized for e-cooling. Its lattice is designed for two modes： the first is the isochronous mode, which is a time-of-flight mass spectrometer for short-lived secondary nuclei, the second is the storage ring mode, which is used for collecting and cooling the secondary rare isotope beams from the transport line. In order to fulfil its purpose, the ion optics can be set to different ion optical modes.