On the $$\bar\partial$$ -problem and dressing method for the complex vector modified KdV equation

Theoretical and Mathematical Physics - Starting from a $$5\times 5$$ local matrix $$\bar\partial$$ -problem, we successfully use the $$\bar\partial$$ -dressing method to derive a hierarchy of...     

Nano Proteolysis Targeting Chimeras (PROTACs) with Anti-Hook Effect for Tumor Therapy

Proteolysis targeting chimera (PROTAC) is an emerging pharmacological modality with innovated post-translational protein degradation capabilities. However, off-target induced unintended tissue effects and intrinsic “hook effect” hinder PROTAC biotechnology to be maturely developed. Herein, an intracellular fabricated nano proteolysis targeting chimeras (Nano-PROTACs) modality with a center-spoke degradation network for achieving efficient dose-dependent protein degradation in tumor is reported. The PROTAC precursors are triggered by higher GSH concentrations inside tumor cells, which subsequently in situ self-assemble into Nano-PROTACs through intermolecular hydrogen bond interactions. The fibrous Nano-PROTACs can form effective polynary complexes and E3 ligases degradation network with multi-binding sites, achieving dose-dependent protein degradation with “anti-hook effect”. The generality and efficacy of Nano-PROTACs are validated by degrading variable protein of interest (POI) such as epidermal growth factor receptor (EGFR) and androgen receptor (AR) in a wide-range dose-dependent manner with a 95 % degradation rate and long-lasting potency up to 72 h in vitro. Significantly, Nano-PROTACs achieve in vivo dose-dependent protein degradation up to 79 % and tumor growth inhibition in A549 and LNCap xenograft mice models, respectively. Taking advantages of in situ self-assembly strategy, the Nano-PROTACs provide a generalizable platform to promote precise clinical translational application of PROTAC.     

塑料闪烁体的辐照特性

利用⁶⁰Co放射源分别对3种塑料闪烁体(BC-408, EJ-200, BC-404)进行辐照损伤研究, 比较辐照前后的透射谱、发射谱及光产额的变化, 发现3种闪烁体在低剂量具有较好的抗辐照性能; 当照射剂量超过1.44×10⁴Gy时,透射谱明显变坏, 光输出减少很严重, 但发射谱却保持不变.     

A Public-Key Traitor Tracing Scheme with Revocation Using Dynamic Shares

We proposed a new public-key traitor tracing scheme with revocation capability using dynamic shares and entity revocation techniques. Our schemes traitor tracing and revocation programs cohere tightly. The size of the enabling block of our scheme is independent of the number of receivers. Each receiver holds one decryption key only. The distinct feature of our scheme is that when traitors are found, we can revoke their private keys (up to some threshold z) without updating the private keys of other receivers. In particular, no revocation messages are broadcast and all receivers do nothing. Previously proposed revocation schemes need update existing keys and entail large amount of broadcast messages. Our traitor tracing algorithm works in a black-box way. It is conceptually simple and fully k-resilient, that is, it can find all traitors if the number of them is k or less. The encryption algorithm of our scheme is semantically secure assuming that the decisional Diffie-Hellman problem is hard.AMS Classification: 11T71, 68P30     

A study of time over threshold (TOT) technique for plastic scintillator counter

A new charge measurement method, time over threshold (TOT), has been used in some gas detectors lately. Here TOT is studied for TOF system, made of plastic scintillator counter, which can simplify the electronics of the system. The signal characteristics are measured and analyzed with a high quality oscilloscope, including noise, pedestal, signal amplitude, total charge, rise time and the correlation between them. The TOT and charge are related and can be fitted by some empirical formula. The charge measurement resolution by TOT is given and this will help the design of TOF electronics.     

XH-NH3(X=F,Cl,Br)质子传递的溶剂效应:簇模型,连续介质模型和离散-连续组合模型的比较

分别采用分子簇模型、连续介质模型和离散-连续组合模型研究了XH-NH3(X=F，Cl，Br)分子内质子传递的溶剂效应．结果表明，对于弱酸性化合物FH-NH3，其溶剂效应主要为短程作用，3个H2O分子即可使其发生质子传递，而简单的连续介质模型得到的仍为分子化合物形式，需进一步包含溶剂效应短程作用．对于强酸性化合物ClH-NH3和BrH-NH3，较弱的溶剂效应即可促使其发生质子传递，分子簇模型和连续介质模型均可合理描述，且与离散-连续组合模型的结果相近．离散-连续组合模型既在从头算水平考虑了溶质分子和第一溶剂化层中溶剂分子间的短程作用，又包含了溶剂效应的长程静电作用，能更准确地描述溶剂化作用，且对弱酸性化合物和强酸性化合物体系均适用．     

Development of a portable and fast wire tension measurement system for MWPC construction

In a multi-wire proportional chamber detector(MWPC), the anode and signal wires must maintain suitable tension, which is very important for the detector's stable and accurate performance. As a result, wire tension control and measurement is essential in MWPC construction. A high pressure3 He MWPC detector is to be used as the thermal neutron detector of the multi-functional reflectometer at China Spallation Neutron Source, and in the construction of the detector, we have developed a wire tension measurement system. This system is accurate,portable and time-saving. With it, the wire tension on an anode wire plane has been tested. The measurement results show that the wire tension control techniques used in detector manufacture are reliable.     

Time calibration for the end cap TOF system of BESⅢ

The time calibration for end cap TOF system of BESⅢ is studied in this paper.It has achieved about 110 ps time resolution for muons in dimu events.The pulse height correction using electronic scan curve and the predicted time calculated using Kalman filter method are introduced.This paper also describes the study of using electrons and muous as calibration samples.     

柴油机排气过程流动的多维瞬态数值模拟研究

柴油机排气过程气体的流动直接影响到排气管换热、发动机噪音、废气再循环系统设计等,对柴油机整体性能起着重要作用.因此,本文利用大型通用CFD软件STAR-CD及ES-ICE,在进气压缩、喷雾燃烧过程多维瞬态数值模拟基础上,对柴油机排气过程流动进行多维瞬态数值模拟研究,通过计算给出排气过程中气体的流场分布,为柴油机排气系统的优化设计提供重要的理论指导.     

多孔介质燃烧-换热器NOx排放的二维数值研究

通过二维单温模型,考虑甲烷燃烧的详细化学反应机理,数值研究多孔介质燃烧-换热器内的燃烧、传热和NO排放规律.研究主要工作参数过量空气系数和燃烧器功率对氮氧化物排放的影响.结果表明,过量空气系数和功率对NO排放有显著的影响.功率一定时,过量空气系数由1.12增大到1.42时,NO体积分数由3.9E-5减少到1.8E-5....