Multi-targeted molecular docking,drug-likeness and ADMET studies of derivatives of few quinoline- and acridine-based FDA-approved drugs for anti-breast cancer activity

Structural Chemistry - Quinoline- and acridine-based drugs are widely used as anti-breast cancer agents. These drugs act through various mechanisms of action; for example, neratinib acts on...     

Horseradish Peroxidase Catalyzed Synthesis of Polycardanol Microcapsules

Polymers synthesized from naturally derived monomers are valuable since they decrease the reliance on petroleum based feed stocks. Cashew nut shell oil (CNSL) is a side-product from processing of edible Cashew nuts of Annacardium occidentale. One of the major components of CNSL is cardanol, which is a phenol derivative having an unsaturated pentadecyl substituent in the ‘meta’ position with varying amount of unsaturation (no double bonds to three double bonds). The substituent in the meta position can also be hydrogenated to yield completely saturated hydrogenated cardanol. Cardanol can be utilized to stabilize the dispersions of oil in water and vice versa since it displays amphiphilic behavior owing to the phenolic head and the C15 aliphatic tail. Here we report the horseradish peroxidase (HRP) catalyzed polymerization of cardanol at oil water interface to obtain polycardanol microcapsules. A synthetic analogue of hydrogenated cardanol, 3-pentadecylphenol (3PDP), was also oxidatively polymerized at the oil-water interface to obtain Poly(3-pentadecylphenol) microcapsules.     

Dual-path handheld system for cornea and retina imaging using optical coherence tomography

Optical Review - A dual-path handheld system is proposed for cornea and retina imaging using spectral domain optical coherence tomography. The handheld sample arm is designed to acquire two images...     

Inhibition of mild steel corrosion by Morinda tinctoria leaves extract in sulphuric acid medium

The corrosion inhibition of mild steel in 0.5 M sulphuric acid by aqueous and acid extracts of leaves of Morinda tinctoria was studied using weight loss, colorimetric and electrochemical techniques. Results obtained indicate that both the extracts are effective in sulphuric acid medium and the efficiency decreases with increase in temperature. Added halide additives improve the efficiency of the inhibitor. From the thermodynamic, spectral, and surface analyses, the nature of adsorption has been found out.     

Damage accumulation and hysteretic behavior of MAX phase materials

The compressive response of fully dense and 10 vol% porous Ti₂AlC MAX phase materials subjected to quasi-static uniaxial and cyclic loading including their repeatable hysteretic behavior is presented. Damage accumulation in the form of kink bands and microcracking is characterized using ultrasonics and scanning electron microscopy under different levels of compressive loading. The observations and measurements are correlated quantitatively using a model based on friction between the crack faces, which is the main dissipation process. The model is shown to capture the hysteretic behavior of Ti₂AlC MAX phase and quantitatively reproduce the experimentally measured stress–strain curves.     

Closure properties of operators on the Ma-Minda type starlike and convex functions

A normalized univalent function f is called Ma-Minda starlike or convex if zf^′(z)/f(z)?φ(z) or 1+zf^″(z)/f^′(z)?φ(z) where φ is a convex univalent function with φ(0)=1. The class of Ma-Minda convex functions is shown to be closed under certain operators that are generalizations of previously studied operators. Analogous inclusion results are also obtained for subclasses of starlike and close-to-convex functions. Connections with various earlier works are made.     

Influence of post-deposition annealing on the structural,optical and electrical properties of Li and Mg co-doped ZnO thin films deposited by sol–gel technique

Lithium (Li) and magnesium (Mg) co-doped zinc oxide (ZnO) thin films were deposited by sol–gel method using spin coating technique. The films were deposited on glass substrates and annealed at different temperatures. The effects of annealing temperature on the structural, optical and electrical properties of the deposited films were investigated using X-ray diffraction (XRD), Ultraviolet–Visible absorption spectra (UV–VIS), photoluminescence spectra (PL), X-ray photo electron spectroscopy (XPS) and Hall measurements. XRD patterns indicated that the deposited films had a polycrystalline hexagonal wurtzite structure with preferred (0 0 0 2) orientation. All films were found to exhibit a good transparency in the visible range. Analysis of the absorption edge revealed that the optical band gap energies of the films annealed at different temperatures varies between 3.49 eV and 3.69 eV. Room temperature PL spectra of the deposited films annealed at various temperatures consist of a near band edge emission and visible emission due to the electronic defects, which are related to deep level emissions, such as oxide antisite (O_Zn), interstitial zinc (Zn_i), interstitial oxygen (O_i) and zinc vacancy (V_Zn) which are generated during annealing process. The influence of annealing temperature on the chemical state of the dopants in the film was analysed by XPS spectra. Ion beam analysis (Rutherford back scattering) experiments were performed to evaluate the content of Li and Mg in the films. Hall measurements confirmed the p-type nature of the deposited films.     

Chemometric and trend analysis of water quality of the South Chennai lakes: an integrated environmental study

In order to bring out the nature of the factors influencing lake water composition, multivariate statistical analysis and trend analysis were performed based on the hydrochemical data of the study area, namely, South Chennai. Change in land use pattern and settlements along the banks of the lakes alters the quality and quantity of the surface water. In the present study, the R‐mode factor analysis and cluster analysis were applied to the geochemical parameters of the water to identify the factors affecting the chemical composition of the lake water. Dendograms of both the seasons give three major clusters, reflecting the groups of unpolluted to moderately polluted, polluted, and heavily polluted stations. The movement of stations from one cluster to another clearly brings out the seasonal variation in the chemical composition of the lake water. The complex hydrochemical data of the surface water were interpreted by condensing them into three major factors. Factor score analysis was used successfully to delineate the stations under study and the role of the contributing factors, and the nature of factors responsible for the variation in chemical composition of the water has been clearly brought out. Results of trend analysis using ArcGIS clearly indicate that the trend in water quality is deteriorating at a faster rate in the eastern part of the study area. It is understood that although natural shifts probably can account for some of the variation, it is most likely that human activities play a major role in affecting the water quality on a regional scale. Copyright © 2014 John Wiley & Sons, Ltd.     

Stress Field Evolution under Mechanically Simulated Hull Slamming Conditions

The effect of repeated loading from mechanically simulated hull slamming on foam core sandwich composites was investigated utilizing a novel technique that simultaneously measured temperature and displacement while cyclic loading occurred. Thermoelastic Stress Analysis (TSA) and Digital Image Correlation (DIC) techniques were combined using a single infrared camera for characterization of the foam core. Improved stress fields with TSA results were found through deformation compensation. Initial work approximating hull slamming conditions mechanically utilizing a custom device were performed. Mechanically loading offers several benefits over water impact investigations, including easy access to the sample during the slamming event, an unobstructed optical path, and accelerated testing. Evolving stress fields under long-duration, repeated simulated hull slamming loading were observed around a growing delamination crack between the foam core and skin.