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排序方式: 共有218条查询结果,搜索用时 15 毫秒
1.
Sing Lai Cong Roy Anitha Hui Lok Yong Mun Chan Sook Rajak Harish Karunakaran Rohini Ravichandran Veerasamy 《Structural chemistry》2022,33(3):649-669
Structural Chemistry - Quinoline- and acridine-based drugs are widely used as anti-breast cancer agents. These drugs act through various mechanisms of action; for example, neratinib acts on... 相似文献
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Fisetin Inhibits UVB‐induced Cutaneous Inflammation and Activation of PI3K/AKT/NFκB Signaling Pathways in SKH‐1 Hairless Mice 下载免费PDF全文
Harish Chandra Pal Mohammad Athar Craig A. Elmets Farrukh Afaq 《Photochemistry and photobiology》2015,91(1):225-234
Solar ultraviolet B (UVB) radiation has been shown to induce inflammation, DNA damage, p53 mutations and alterations in signaling pathways eventually leading to skin cancer. In this study, we investigated whether fisetin reduces inflammatory responses and modulates PI3K/AKT/NFκB cell survival signaling pathways in UVB‐exposed SKH‐1 hairless mouse skin. Mice were exposed to 180 mJ cm?2 of UVB radiation on alternate days for a total of seven exposures, and fisetin (250 and 500 nmol) was applied topically after 15 min of each UVB exposure. Fisetin treatment to UVB‐exposed mice resulted in decreased hyperplasia and reduced infiltration of inflammatory cells. Fisetin treatment also reduced inflammatory mediators such as COX‐2, PGE2 as well as its receptors (EP1–EP4) and MPO activity. Furthermore, fisetin reduced the level of inflammatory cytokines TNFα, IL‐1β and IL‐6 in UVB‐exposed skin. Fisetin treatment also reduced cell proliferation markers as well as DNA damage as evidenced by increased expression of p53 and p21 proteins. Further studies revealed that fisetin inhibited UVB‐induced expression of PI3K, phosphorylation of AKT and activation of the NFκB signaling pathway in mouse skin. Overall, these data suggest that fisetin may be useful against UVB‐induced cutaneous inflammation and DNA damage. 相似文献
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Harish K. Patney 《合成通讯》2013,43(16):2229-2233
A mild and efficient procedure for the protection of carbonyl compounds as 1,5-dihydro-3H-2,4-benzodithiepines in high yields is described by using a readily available and inexpensive KSF clay catalyst. 相似文献
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Harish K. Patney 《合成通讯》2013,43(22):2329-2333
Sulfonated charcoal has been demonstradted to be very effective and mild catalyst for the tetrahydropyranylation of alcohols and phenols. 相似文献
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Harish Holla Ian D. Jenkins Juliette E. Neve Rebecca H. Pouwer Ngoc Pham Simon J. Teague Ronald J. Quinn 《Tetrahedron letters》2012,53(52):7101-7103
A synthesis of the unusual cyclobutane-quinolinone alkaloids melicodenines C, D and E by intermolecular [2+2] cycloaddition is described. 相似文献
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Amit K. Gupta Harish Manoj K. Rai Mahendra Phulwaria Tanvi Agarwal N. S. Shekhawat 《Applied biochemistry and biotechnology》2014,173(6):1481-1494
The present study described an improved and reproducible in vitro regeneration system for Terminalia arjuna using nodal segment explants obtained from a mature plant. Shoot tips excised from in vitro proliferated shoots were encapsulated in 3 % sodium alginate and 100 mM CaCl2?2H2O for the development of synthetic seeds which may be applicable in short-term storage and germplasm exchange of elite genotype. Shoot multiplication was significantly influenced by a number of factors, namely types and concentrations of plant growth regulators, medium composition, repeated transfer of mother explants, subculturing of in vitro regenerated shoot clumps, agar concentrations, and temperature. Maximum numbers of shoots (16.50?±?3.67) were observed on modified Murashige and Skoog (MMS) medium containing 0.5 mg l?1 of benzylaminopurine (BAP) and 0.1 mg l?1 of naphthalene acetic acid (NAA). To shortening the regeneration pathway, rooting of micropropagated shoots under in vitro condition was excluded and an experiment on ex vitro rooting was conducted and it was observed that the highest percentage of shoots rooted ex vitro when treated with indole-3-butyric acid (IBA, 250 mg l?1)?+?2-naphthoxy acetic acid (NOA, 250 mg l?1) for 5 min. The well-developed ex vitro rooted shoots were acclimatized successfully in soilrite under greenhouse conditions with 80 % survival of plants. Randomly amplified polymorphic DNA (RAPD) analysis confirmed that all the regenerated plants were genetically identical to the mother plant, suggesting the absence of detectable genetic variation in the regenerated plantlets. To the best of our knowledge, this is the first report on synthetic seed production as well as ex vitro rooting and genetic fidelity assessment of micropropagated shoots of T. arjuna. 相似文献
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Moritz Balkenhohl Harish Jangra Ilya S. Makarov Shu‐Mei Yang Hendrik Zipse Paul Knochel 《Angewandte Chemie (International ed. in English)》2020,59(35):14992-14999
The development of a predictive model towards site‐selective deprotometalation reactions using TMPZnCl?LiCl is reported (TMP=2,2,6,6‐tetramethylpiperidinyl). The pKa values of functionalized N‐, S‐, and O‐heterocycles, arenes, alkenes, or alkanes were calculated and compared to the experimental deprotonation sites. Large overlap (>80 %) between the calculated and empirical deprotonation sites was observed, showing that thermodynamic factors strongly govern the metalation regioselectivity. In the case of olefins, calculated frozen state energies of the deprotonated substrates allowed a more accurate prediction. Additionally, various new N‐heterocycles were analyzed and the metalation regioselectivities rationalized using the predictive model. 相似文献