This study investigated vitamin K
1 (VK
1) distribution following intravenous vitamin K
1–fat emulsion (VK
1–FE) administration and compared it with that after VK
1 injection. Rats were intravenously injected with VK
1–FE or VK
1. The organ and tissue VK
1 concentrations were determined using high‐performance liquid chromatography method at 0.5, 2 and 4 h to determine distribution, equilibrium and elimination phases, respectively. In the VK
1–FE group, the plasma, heart and spleen VK
1 concentrations decreased over time. However, other organs like liver, lung, kidney, muscle and testis, reached peak VK
1 concentrations at 2 h. In the VK
1 injection group, the liver VK
1 concentrations were significantly higher than those in other organs at the three time points. However, VK
1 concentrations in the other organs peaked at 2 h. In addition, in VK
1–FE group, the heart, spleen and lung VK
1 concentrations were significantly higher than those in the VK
1 injection group at the three time points, and the liver VK
1 concentration was significantly higher than that in the VK
1 injection group at 4 h. The VK
1 amount was greatest in the liver compared with the other organs. Thus, the liver is the primary organ for VK
1 distribution. The distribution of VK
1 is more rapid when injected as VK
1–FE than as VK
1. Copyright © 2015 John Wiley & Sons, Ltd.
相似文献