CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP

Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR, UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice, III_a showed an inhibitionrate of 43%.     

高分子药物研究——Ⅻ.侧链含5-氟尿嘧啶聚酰胺的合成及其抗肿瘤活性研究

本文用N-(5-氟尿嘧啶乙酰)谷氨酸双对硝基苯酯与一系列α、ω-多次甲基二胺缩聚制备了6种侧链含5-氟尿嘧啶的聚酰胺。通过元素分析、核磁共振谱、红外光谱和紫外光谱对单体和聚合物的结构进行了鉴定。经初步抗动物肿瘤试验,聚α-(5-氟尿嘧啶乙酰胺基)戊二酰乙二胺对艾氏腹水癌的抑制率为43.0％。