| CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP |
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| 引用本文： | 卓仁禧,范昌烈,麦才淞,赵儒林,易锦.CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP[J].高分子科学,1986,0(2):165-169. |
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| 作者姓名： | 卓仁禧 范昌烈 麦才淞 赵儒林 易锦 |
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| 作者单位： | Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan |
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| 摘 要： | Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR, UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice, III_a showed an inhibitionrate of 43%.
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| 收稿时间： | 1985-03-16 |
CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP |
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| ZHUO Renxi,FAN Changlie,MAI Caison,ZHAO Rulin,YI Jin.CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP[J].Chinese Journal of Polymer Science,1986,0(2):165-169. |
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| Authors: | ZHUO Renxi FAN Changlie MAI Caison ZHAO Rulin YI Jin |
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| Institution: | Department of Chemistry; Wuhan University; Wuhan |
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| Abstract: | Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR, UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice, IIIa showed an inhibitionrate of 43%. |
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