| 高分子药物研究——Ⅻ.侧链含5-氟尿嘧啶聚酰胺的合成及其抗肿瘤活性研究 |
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| 引用本文： | 卓仁禧,范昌烈,麦才淞,赵儒林,易锦.高分子药物研究——Ⅻ.侧链含5-氟尿嘧啶聚酰胺的合成及其抗肿瘤活性研究[J].高分子学报,1987,0(4):271-275. |
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| 作者姓名： | 卓仁禧 范昌烈 麦才淞 赵儒林 易锦 |
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| 作者单位： | 武汉大学化学系
(卓仁禧，范昌烈，麦才淞，赵儒林)，武汉大学化学系(易锦) |
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| 摘 要： | 本文用N-(5-氟尿嘧啶乙酰)谷氨酸双对硝基苯酯与一系列α、ω-多次甲基二胺缩聚制备了6种侧链含5-氟尿嘧啶的聚酰胺。通过元素分析、核磁共振谱、红外光谱和紫外光谱对单体和聚合物的结构进行了鉴定。经初步抗动物肿瘤试验,聚α-(5-氟尿嘧啶乙酰胺基)戊二酰乙二胺对艾氏腹水癌的抑制率为43.0％。
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| 关 键 词： | 5-氟尿嘧啶 谷氨酸 聚酰胺 生物活性 抗癌药物 |
| 收稿时间： | 1985-03-16 |
CHEMOTHERAPEUTIC POLYMER XII. Synthesis and Antitumor Activity of Poly [methylene α-(5-Fluorouracil-1-acetyl-amino) glutaramide] |
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| ZHUO Ren-xi,FAN Chang-lie,MAI Cai-song,ZHAO Ru-lin,YI Jin.CHEMOTHERAPEUTIC POLYMER XII. Synthesis and Antitumor Activity of Poly [methylene α-(5-Fluorouracil-1-acetyl-amino) glutaramide][J].Acta Polymerica Sinica,1987,0(4):271-275. |
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| Authors: | ZHUO Ren-xi FAN Chang-lie MAI Cai-song ZHAO Ru-lin YI Jin |
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| Institution: | Department of Chemistry; Wuhan University; Wuhan |
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| Abstract: | Six polyamides containing 5-fluorouracil in the side chain were synthesized by the condensation of di-p-nitrophenyl N-(5-fluorouracil-l-acetyl)-glutamate with a series of polymethy-lene diamines. All of the new polyamides obtained are solid powder and soluble in water. Their chemical structures were identified by 1H-NMR, UV and IR spectra as well as elemental analysis. The antitumor activity of some of these polyamides were tested against Ehrlich ascites carcinoma in mice. Poly ethylene α-(5-fluorouracil-l-acetyl-amino) glutaramide] showed an inhibition rate of 43%. 5-Fluorouracil, Glutamic Acid, Polyamide Biological Activity, Anticar-cinogen |
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| Keywords: | 5-Fluorouracil Glutamic Acid Polyamide Biological Activity Anticar-cinogen |
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