Doxorubicin-containing microparticles comprising cinnamoyl gelatin-folic acid conjugate,cinnamoyl Pluronic F127, and cinnamoyl poly(β-cyclodextrin)

Microparticles comprising of cinnamoyl gelatin (type A) (CA-GelA), cinnamoyl gelatin (type B) (CA-GelB), cinnamoyl Pluronic F127 (CA-Plu), and cinnamoyl poly(β-cyclodextrin) (CA-P(βCD)) were prepared as a carrier for doxorubicin (DOX). Folic acid (FA) was covalently attached to CA-GelA as a targeting molecule for cancer cells. The covalent attachment of FA was confirmed by ¹H-NMR spectroscopy. On the TEM micrographs, the microparticles were almost circular and they were a few hundreds of nanometers in diameter. The release at pH7.4 of DOX from microparticle/DOX suspension was more extensive when the FA content of microparticles was lower and the temperature of release medium was higher. According to the flow cytometric analysis, the lager amount of FA seemed to make the interaction of the microparticle and KB cell more favorable. On confocal laser fluorescence micrograph, the cell treated with microparticle bearing FA showed relatively strong DOX fluorescence, indicating the strong interaction of the microparticle and KB cells.     

Syntheses,characterizations and bioactivities on HeLa cells and KB cells of two dinuclear manganese complexes with carboxylate bridges

To explore anti-tumor activities of manganese complexes, two complexes have been synthesized and characterized. Complex 1 is bridged by 1,10-phenanthroline and 2,4-biphenyl dicarboxylate. The two complexes have strong fluorescent emission and interact with DNA in an intercalative mode. The complexes also exhibit significant cytotoxic specificity and cancer cell inhibition.     

GROIN: a fast optical adjustment of a Kirkpatrick–Baez set‐up

A very simple and compact optical device aimed at the fast adjustment, alignment and bending of the mirrors of a Kirpatrick–Baez system used in the X‐ray domain is described.     

X射线Kirkpatrick-Baez显微镜用超反射镜的研制

 介绍了一种可应用于X射线Kirkpatrick-Baez（KB）显微镜的光学元件—X射线超反射镜。选用的W和B₄C作为镀膜材料，膜对数为20，采用单纯型调优的方法实现了X射线超反射镜设计，用磁控溅射的方法在Si基片上完成了W/B₄C X射线超反射镜的制备。采用高分辨率X射线衍射仪（8 keV）测量了X射线超反射镜的反射特性。制备的X射线超反射镜在掠入射角分别为1.052°和1.143°处，反射角度带宽为0.3°，反射率达到20%，可满足KB型显微镜的要求。     

Studies on chemistry and immuno‐ modulating mechanism of a glycoconjugate from Lycium barbarum L.

The detailed structure of an O‐glycan derived from the fruit of Lycium barbarum L. was elucidated based on glycosidic linkage analysis, complete and partial acid hydrolysis, ¹H‐NMR and ¹³C NMR spectroscopy. According to the experiments, the carbohydrate was in the form of polysacchride (arabinogalactan) chains with highly branched 3, 4‐galactans and terminal arabinofuranosyl substituents. The immuno‐modulating mechanism of glycoconjugate and its glycan were investigated using tritium thymidine incorporation assay, flow cytometry assay and electrophoretical mobility shift assay (EMSA). The results suggested that the immunoactive components of the fruit of Lycium barbarum L. could enhance the splenocyte proliferation in normal mice and the effects of glycan chain were stronger than those of glycoconjugate. The target cell was most likely to be B‐lymphocyte, on which existed receptor binding site acting with the glycan. In addition, the immuno‐stimulatory effect of glycoconjugate (LbGp4) and its glycan (LbGp4‐OL) was associated with activating the expression of nuclear factor KB (NF‐KB) and activator protein 1 (AP‐1).     

辐射驱动内爆流线实验测量

内爆速度的测量是惯性约束聚变研究中的核心问题, 是判断聚变点火反应的关键物理量. 在神光II激光装置上, 利用KB显微镜配合时间分辨为10 ps的条纹相机, 对1600 J激光能量注入, 3倍频, 脉宽为1 ns黑腔辐射驱动CH靶球, 获得了清晰的辐射驱动内爆流线轨迹X射线图像. 通过流线轨迹图像给出了最大内爆速度为160 km/s. 利用Multi1D程序对内爆压缩流线和壳层速度变化进行了模拟, 实验数据和理论模拟较符合.     

A modified method of averaging for solving a class of nonlinear equations

ＡＭＯＤＩＦＩＥＤＭＥＴＨＯＤＯＦＡＶＥＲＡＧＩＮＧＦＯＲＳＯＬＶＩＮＧＡＣＬＡＳＳＯＦＮＯＮＬＩＮＥＡＲＥＱＵＡＴＩＯＮＳＺｈａｎｇＢａｏ－ｓｈａｎ（张宝善）（ＤｅｐａｒｉｍｅｎｔｏｆＭａｉｈ．,ＸｕｚｈｏｕＴｅａｃｈｅｒｓＣｏｌｌｅｇｅ,Ｘｕｚｈ...     

用于几keV能点动态成像诊断的KB-KBA混合型光学系统设计

围绕激光ICF研究中几keV能点的动态成像诊断需求,提出了具有大视场、高空间分辨、高集光效率和谱分辨特性的新型KB-KBA混合型光学结构。该结构以子午方向上两块单层膜球面镜校正像差,实现大视场内的高空间分辨;在弧矢方向上用一块多层膜球面镜聚焦,以保证较高的集光效率和谱分辨能力。该结构克服了传统单层膜和周期膜KBA结构在几keV能点动态成像诊断中存在的集光效率低,强度不均匀和有效视场受限等不足。针对2.5 keV和4.3 keV两个能点,给出了光学初始结构和膜系的设计,建立了考虑膜系反射性质的光线追迹模型。模拟结果表明,该KB-KBA混合型结构在子午方向1.4 mm视场内空间分辨均优于5μm,有效集光效率优于2×10~(-7)sr,可以满足动态成像诊断的需求。     

Tests and characterization of a laterally graded multilayer Montel mirror

Multilayers are becoming an increasingly important tool in X‐ray optics. The essential parameters to design a pair of laterally graded multilayer mirrors arranged in a Montel‐type configuration for use as an X‐ray collimating device are provided. The results of X‐ray reflectometry tests carried out on the optics in addition to metrology characterization are also shown. Finally, using experimental data and combined with X‐ray tracing simulations it is demonstrated that the mirror meets all stringent specifications as required for a novel ultra‐high‐resolution inelastic X‐ray scattering spectrometer at the Advanced Photon Source.