三种非甾体类抗炎药与脂质体的相互作用

以卵磷脂脂质体为生物膜模型, 分别采用二阶导数吸收光谱法和以1-苯胺基-8-萘磺酸铵(ANS)为探针的荧光光谱法, 研究了三种丙二酸类非甾体抗炎药吲哚美辛、舒林酸和托美丁与脂质体的相互作用. 药物的二阶导数吸收谱成沟槽型,在脂质体中沟槽变浅, 但波长基本上不移动, 表明药物结合在磷脂双层的表面而没有进入到脂双层内部. 在荧光光谱中, 抗炎药可以结合到脂质体上, 游离出ANS, 猝灭ANS 在脂质体中的强烈荧光, 表观猝灭常数K_SV^app＞10^12 L·mol^(-1); 药物先行结合到脂质体上后, 会降低ANS结合到脂质体上的机率. 同样表明药物可以结合到脂质体表面磷脂分子的头部, 结合能力的强弱与吸收谱得到的结果一致, 舒林酸最强, 吲哚美辛其次, 托美丁的结合能力较弱.     

非全局Lipschitz条件下跳适应向后Euler方法的强收敛性分析

本文研究跳适应向后Euler方法求解跳扩散随机微分方程在非全局Lipschitz条件下的强收敛性.通过克服方程非全局Lipschitz系数给收敛性分析带来的主要困难,我们成功地建立了跳适应后向Euler方法的强收敛性结果并得到相应的收敛率.最后,我们通过数值试验对前文所得理论结果做进一步的验证.     

光催化降解染料ZnO催化剂的性能

光催化法是20世纪70年代发展起来的新型水处理技术，即以某些半导体材料为催化剂，利用光催化法来降解环境污染物。该方法工艺简单，成本较低，在常温下能使大多数不能或难于生物降解的有毒有机物彻底氧化分解。近年来研究最多的是TiO2，由于其带隙较宽(3．2eV)，只能吸收波长λ≤387nm的紫外光，因此研制新型光催化剂仍是重要课题。     

Polyethylenimine （PEI）-g-comb-poly（ethylene glycol）-transferrin（Ⅰ）： Tumor-targeted Vector for Gene Delivery In.vitro

The work described the synthesis and evaluation of PEI-g-comb-PEG-transferrin as a potential system for gene therapy in vitro. The MW of PEG was 10KDa, and PEI was 2KDa. Its structure was identified by NMR, FT-IR and TGA spectroscopy. MTT assay found that at concentration up to 4000 n mol/L of the polymer, cell viability was over 85%. The bio-character of polymer/DNA complex was characterized by agarose gel electrophoresis, ethidium bromide exclusion and zeta-potential assay. The polymer could retardate DNA at N/P ratio 3.0-3.5 （mol/mol）. The particle size of the polymer/DNA complex was less than 300 nm. Transfection efficiency of the complex was studied in COS7 and NT2 cell lines.     

非含氟型磺化聚合物质子交换膜材料的研究进展(下)

概述了近十年来非含氟型磺化聚合物质子交换膜材料的研究进展,包括各种材料的制备和性质,详细地讨论了材料的化学结构、形态与其性能(质子导电率、耐水性、尺寸稳定性、吸水率、抗自由基氧化性、甲醇透过率等)之间的关系,其中结合作者在磺化聚酰亚胺方面的研究工作,重点对这类材料进行了系统、深入的介绍和讨论.最后,本文还对今后燃料电池用质子交换膜材料的研究提出了一些设想和展望.本文分为上下两篇,其中下篇主要综述了非含氟型磺化聚合物的性能与结构形态之间的关系.     

7—羟基4—甲基香豆素的倍频性能研究

７－羟基－４－甲基香豆素的倍频性能研究周为群（苏州大学生物技术学院苏州２１５１５１）曹阳（苏州大学化学化工学院苏州２１５００６）关键词二阶极化率７－羟基－４－甲基香豆素ＳＨＧ效应倍频材料中图分类号Ｏ７３４．１从七十年代至今，人们对探究有机倍频材料已作...     

An Efficient Deselenenylation Reaction to the Synthesis of 3, 5-Disubstituted Isoxazoline and Isoxazole

The development of organoselenium chemistry1 has been expanding rapidly during the last decades. Among them, organic selenides are key intermediates, for that they can be efficiently introduced, manipulated, and removed through selenoxide syn-elimination2. Our research group3 has been interested in the application of selenium in organic synthesis for several years. Isoxazolinyl substituted phenyl selenide 13a, although a β-H exists in the molecule, did not undergo selenoxide syn-elimination e…     

YbB6的能带结构和光电导率谱的解析

用密度泛函（GGA＋U）方法研究YbB6晶体的电子结构。采用FLAPW方法进行计算,获得了比较精确的能带结构信息。分析了YbB6能带结构的特征与Yb-B6簇间成键情况的联系。在此基础上计算YbB6的反射率、介电函数、光电导率和能量损失函数等光学常数,结果与实验值符合比较好。对其光电导率（实部）和能量损失函数谱进行详细分析,对谱峰作出指认,阐明了各谱峰与能带间电子跃迁的联系,证实了前人对谱峰所作经验指认的合理部分,补充和纠正了前人经验指认的不足和不准确之处。     

Diffusion of Acetic Acid Across Oil/Water Interface in Emulsification-Internal Gelation Process for Preparation of Alginate Gel Beads

Alginate has been widely used in cell microencapsulation and drug delivery systems in the form of gel beads or microcapsules.Although an alternative novel emulsification-internal gelation technology has been established and both the properties and the potential applications of the beads in drug delivery systems have been studied,the mechanism has not been well understood compared with the traditional droplet method(external gelation technology).On the basis of our previous knowledge that the novel technology is composed of complicatedly consecutive processes with multistep diffusion and reaction,and the diffusion of acetic acid across oil/water interface being the prerequisite that determines the occurrence and rate for the reactions and the structures and properties of final produced gel beads,a special emphasis was placed on the diffusion process.With the aid of diffusion modeling and simple experimental design,the diffusion rate constant and diffusion coefficient of acetic acid across oil/water interface were determined to be in the orders of magnitude of 10-6 and 10-16,respectively.This knowledge will be of particular importance in understanding and interpreting the formation,structure of the gel beads and the relationship between the structure and properties and guiding the preparation and quality control of the gel beads.     

导数吸附伏安法同时测定柠檬黄及日落黄

色素日落黄和柠檬黄在ｐＨ８．２的硼酸钠－酸介质中均有良好的吸附伏安波，但波峰相互重叠，难以同时测定。本文提出以二阶导数法对日落黄和柠檬黄的重叠伏安波谱进行分析，以达到日落黄和柠檬黄同时测定的目的，方法简便快速。本法分析几种饮料中的日落黄及柠檬黄，结果满意。