A Hydrochlorothiazide-Imprinted Polymer

ABSTRACT

Hydrochlorothiazide (HCT) is a medicine commonly used as a diuretic. A series of HCT-imprinted polymers were prepared using 4-vinylpyridine or methacrylic acid or none as a functional monomer. Liquid chromatographic analysis using the polymers as a stationary phase showed that 4-vinylpyridine was suitable for synthesizing HCT-selective polymers. It appeared that the sulfonamide groups on HCT molecule could interact with 4-vinylpyridine through ionic interaction, and thus could be used as a functional group for molecular imprinting. The prepared HCT-specific polymers should have applications for clinical analysis of HCT.     

新型锌离子荧光探针(5-(二甲基氨基)-N-(4-(2-(2-喹啉亚甲基)甲酰肼基)苯基)萘-1-磺酰胺)的研究

以丹磺酰胺为荧光基团设计合成了新型Zn²⁺荧光探针DW1(5-(二甲基氨基)-N-(4-(2-(2-喹啉亚甲基)甲酰肼基)苯基)萘-1-磺酰胺)。通过紫外光谱、荧光光谱及电喷雾质谱研究了DW1对Zn²⁺的选择性识别作用。结果表明,DW1与Zn²⁺结合后荧光显著增强,荧光发射光谱由545 nm蓝移至515 nm,量子产率达到0.32,且对Zn²⁺具有较高的选择性,受常见离子的干扰较小。光谱滴定和ESI-MS谱表明DW1与Zn²⁺以1∶1的化学计量数形成配合物,平衡常数K=1.75×10⁴(mol/L)^-1。     

Solvent Effects on the Chemoselectivity of Stable Phosphorus Ylides Involving a Sulfonamide

Hydrazine sulfonamide derivatives undergo a smooth reaction with dialkyl acetylenedicarboxylates in the presence of triphenylphosphine in varieties of solvent for generation of phosphorus ylides in a chemoselective manner.     

Toxicological effects,biological aspects and spectral characterization of organoboron(III) complexes of sulfonamide‐imines

The toxicological effects, biological aspects and spectral characterization of organoboron(III) complexes of sulfonamide‐imines derived by the condensation of salicylaldehyde with different sulfa‐drugs are described. The benzene‐soluble, high‐molecular‐weight complexes have been characterized using a wide range of analytical and spectroscopic techniques, viz. UV, IR, ¹H and ¹¹B NMR. On the basis of these studies, it is inferred that the imines derived from sulfa drugs and salicylaldehyde behave as dibasic tridentate ligands and thus provide a tetrahedral environment around the boron atom. Finally, all these complexes have been screened for their antimicrobial activity against a variety of fungal and bacterial strains and their toxicological effects on male albino rats examined at the dosages employed. Copyright © 2004 John Wiley & Sons, Ltd.     

液相色谱-高分辨质谱测定贝类中的4种贝毒素及16种兽药残留

建立了贝类组织中米氏裸甲藻贝毒素(Gymnodimine,GYM)、螺环内酯毒素(Spirolides,SPX1)、大田软骨酸贝毒素(Okadaic acid,OA-C)、蛤毒素(Pectenotoxins,PTX2)4种腹泻性贝类毒素、氯霉素、氟甲砜霉素以及14种磺胺类药物的液相色谱-高分辨质谱分析方法。样品采用甲醇提取,正己烷去除脂肪,乙酸乙酯反萃取,ODS粉分散固相萃取净化,经Agilent ZORBAX SB-C18色谱柱(3.0 mm×100 mm,1.8μm)分离,高分辨质谱仪进行检测。结果表明,各化合物在一定的质量浓度范围内线性良好,相关系数(r)均大于0.99。GYM,SPX1,OA-C,PTX2 4种腹泻性贝类毒素的定量下限分别为0.5,0.1,2.0,0.5μg/kg,各化合物在低、中、高3个浓度加标水平下的回收率为70.1%~105.8%,相对标准偏差(RSD)为10.1%~14.8%。该方法具有简单、快速、灵敏等特点,能满足贝类产品中贝类毒素、抗生素的检测要求。     

RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis

DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on‐DNA chemistries to incorporate medicinally relevant and C?S, C?P and N?S linkages into DELs, which are underrepresented in the canonical methods.     

Organosilicon(IV) and organotin(IV) complexes as biocides and nematicides: synthetic,spectroscopic and biological studies of N∩N donor sulfonamide imine and its chelates

A brief account is given of the synthesis and stereochemistry and the antibacterial, antifungal, nematicidal and insecticidal behaviour of organosilicon(IV) and organotin(IV) complexes of a biologically potent ligand, 2‐acetylfuransulfaguanidine. The unimolar and bimolar substitution products have been characterized by elemental analyses, conductance measurements, molecular weight determinations, and spectral studies, viz. IR, ¹H NMR, ¹³C NMR, UV, ²⁹Si NMR and ¹¹⁹Sn NMR spectra. The data support the binding of the nitrogen atom to the metal atom in R₃M(N^∩N), [R₂M(N^∩N)₂ and R₂M(N^∩N)Cl [(R = Me/Ph and M = Si(IV) and Sn(IV)] types of complex. Based on these studies, with coordination number five and six a trigonal bipyramidal and an octahedral geometry have been proposed for the resulting derivatives. The free ligand (N^∩NH) and its respective metal complexes were tested in vitro against a number of microorganisms to assess their antimicrobial properties. The results are indeed positive. In addition to these studies, the complexes also show good nematicidal and insecticidal properties. The results of these findings have been discussed in detail. Copyright © 2004 John Wiley & Sons, Ltd.     

Synthesis and Structure of bc-Dichloro-af-dihydroxo-de-bis（N-3- pyridinylmethanesulfonamide）platinum（IV） Diydrate

The Pt(IV) complex cis,cis,trans-[Pt(PMSA)2Cl2(OH)2]·2H2O(1), where PMSA = N-3-pyridinylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity and...     

苦参碱磺胺类拼合物的合成

以1-溴-2-氯乙烷或1-溴-3-氯丙烷为连接链,将苦参碱和磺胺类化合物连接起来合成了8个新型的苦参碱磺胺类拼合物,其结构经1H NMR,IR和MS表征。