研究生分析仪器课程教学改革与实践

针对研究生分析仪器课程教学中存在的问题,在分析化学课程教学内容中引入分析化学领域最前沿知识,并将讲授法、讨论法、案例分析法及Seminar有机地融入分析化学课程教学中。     

分析化学教学体系重构之思考

结合分析化学学科的发展和分析化学学科的内涵定义,对现行分析化学课程的教学内容进行了分析,指出了现行分析化学课程教学的缺失,提出了以识别与信号传导原理、分析质量控制与保证原理、分析方法原理与技术、分析技术平台等主要知识模块构成分析化学教学体系的设想,并以教学案例进行了初步的探索。     

后MOOC时期高职分析化学混合式教学模式构建

为了全面提高后MOOC时期的高职院校分析化学课程教学质量，提出了基于SPOC的分析化学课程混合式教学模式。首先分析了高职学生的特点和分析化学课程教学中的主要问题；然后根据基于SPOC的混合式教学模式构建流程，依次阐述了课程分析、整体设计、资源开发、教学过程和评价考核设计的原则与思路；最后探讨了基于翻转课堂的分析化学课程混合式教学环境与实施过程。     

案例教学法在分析化学理论教学中的实践研究

研究了案例教学法在分析化学理论教学中的实践,内容包括案例选材、设计、实施和案例模型评估。案例教学法模式在促进学生扎实学习理论知识的同时,改进学生对于分析化学课程的认知,提高学生的专业技能。案例教学法在分析化学理论教学中的实践可以在教师教学和学生学习之间建立良好的互动关系,并最终改善分析化学课程教学。     

高师本科分析化学双语教学的探索与实践

本文在高师分析化学课程双语教学实践的基础上,对分析化学课程双语教学的内容与设计、成绩的评定、实施过程和存在的问题及建议进行了探讨.     

农林高校无机及分析化学基础课教学改革探索与实践

化学课程为农林专业不可或缺的基础课,无机及分析化学是化学课程的必要基础。无机及分析化学的教学质量对促进化学类课程质量提高,进而促进农林专业课程的提升甚为重要。本文分析比较了当前无机及分析化学线上线下教学方法,探讨了浙江农林大学无机及分析化学教学中存在的一些不足,提出无机及分析化学加强教学内容设计、交叉融合化学课程及专业课,缩小个体差异、满足学生个性化需求,改进教学模式、加强课程思政建设等解决方案。并在无机及分析化学教学中实践,教学效果得到明显改善,学生的学习效率、学习能力及化学思维能力明显提升。     

分析化学理论教学中课程思政的实践与探索

以分析化学理论教学中的课程思政为主题,概述了分析化学课程思政建设的研究现状;从思政目标的建立、课程思政的教学探索、教师素养三方面对专业课程思政进行了实践探索;通过精准备课、优化课堂互动、构建反馈渠道等方式,实现知行合一的课程思政教学目标。     

新工科背景下分析化学中质量保证和质量控制的教学改革探究*

通过对目前分析化学教学中存在问题的分析,探究了新工科背景下分析化学专业中关于质量保证和质量控制方面的教学改革,提出了增设“分析化学中的质量保证和质量控制”或者类似的课程的建议,指出分析化学的教学应该围绕整个分析过程展开,并将分析化学中的质量保证和质量控制知识融入分析全过程中,注重理论课程与实践课程相互结合的同时更加强调应用性,增强学生的实践能力和分析问题、解决问题的能力。此外,分析化学教学重在“分析”,要与分析实验室/检测机构保持紧密联系,应建立以市场为导向、以技术为核心的教学活动,从而实现为社会不断培养与时俱进的分析人才的教育目标。     

非化学专业无机及分析化学理论与实验教学的一致性

在"讲一练二考三"新型教学理念的指导下,结合多年非化学专业无机及分析化学课程理论教学和实验教学的经验,针对无机及分析化学理论课和实验课教学的特点和存在的一些问题,阐述了在无机及分析化学课程教学中理论课教学内容和实验课教学内容相结合的实践探索和体会,以及取得的效果。     

基于中国大学MOOC、慕课堂和QQ群三结合的分析化学课程在线教学实践

中国地质大学(武汉)分析化学课程团队采用国家精品在线开放课程作为课程资源、慕课堂作为智慧教学工具、QQ群作为在线讲授和辅导答疑的平台,成功地开展了分析化学课程在线教学实践。实践表明,基于MOOC、慕课堂和QQ群三结合的在线教学形式受到了学生的欢迎和喜爱,学生普遍易于接受,参与积极性高,初显教学效果较好。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.