微波辅助组合合成的研究进展

微波辅助组合合成技术是近年来发展起来的一种新的制备化合物库的组合化学技术, 它不仅可以克服传统固相组合合成技术以及液相组合合成技术无法提高产物收率的不足, 而且利用该技术所制得的化合物库中对应的是高纯度的单一化合物, 采用高通量筛选技术可以快速直接地确定高活性结构, 极大地提高了新药开发的效率. 主要就近年来微波辅助组合合成技术的研究进展情况进行介绍, 内容包括固相组合合成、基于聚合物支载的催化剂的组合合成、液相组合合成、氟相组合合成以及组合平行合成等.     

离子热法合成分子筛的研究进展

离子热法是以离子液体或低共熔混合物为介质的一种新型的分子筛合成方法, 它提供了一种离子态的独特合成环境, 为合成新型分子筛及研究分子筛的生成机理提供了机会. 本文综述了离子热法在分子筛合成方面取得的一些进展, 包括合成方法的创新、合成机理的研究、新材料的合成以及新型催化剂的制备等, 并展望了其发展前景.     

液相组合合成研究进展

综述了近年来液相组合合成的研究进展,主要包括液相组合合成法(LPCS),氟合成,树状载体组合合成及高分子辅助试剂在液相组合合成中的应用等。     

SAPO分子筛的合成及影响因素的研究进展

本文综述了SAPO分子筛的主要合成方法,包括水热合成法、气相晶化法、液相晶化法、微波合成法、变温陈化法、超声合成法、程序升温法等方法.讨论了反应物的组成、模板剂、酸碱度、介质、晶化温度、晶化时间等因素对SAPO分子筛合成的影响.最后对SAPO分子筛合成方法进行了展望.     

钐试剂在有机合成中的应用

钐试剂在有机合成中的应用是近年来有机合成方法学研究中的热点之一。综述了十余年来本课题组在钐试剂应用于有机合成方面所开展的有关工作：(1)二碘化钐作为偶联剂和还原剂在有机合成中的应用;(2)金属钐直接应用于有机合成;(3)三碘化钐作为路易斯酸应用于有机合成;(4)有机钐试剂在有机合成中的应用。     

糖肽合成的新进展

本文综述了近年来在糖肽合成方面的研究进展, 主要包括三氯乙酰亚胺酯法, 缩水内醚糖法, 酶合成法, 固相合成法及酶与固相结合法。分析了不同的离去基团和不同的保护基策略对糖肽合成的影响。     

稀土发光材料的合成方法

简要介绍了合成稀土发光材料的6种方法,包括水热合成法、溶胶-凝胶法、微波辐射法、燃烧合成法以及共沉淀法。参考文献31篇。     

Wallichanol类天然产物ABC环系合成研究

Wallichanol是一类具有独特桥环结构的二萜天然产物.以2-甲基-1,3-环己二酮作为起始原料,通过高立体选择性的Diels-Alder反应和金催化的炔烃碳环化反应构建Wallichanol的ABC三环核心骨架,共七步路线,总收率为42%.该合成工作为Wallichanol类天然产物全合成奠定了研究基础.     

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

The concept of flow “fine” synthesis, that is, high yielding and selective organic synthesis by flow methods, is described. Some examples of flow “fine” synthesis of natural products and APIs are discussed. Flow methods have several advantages over batch methods in terms of environmental compatibility, efficiency, and safety. However, synthesis by flow methods is more difficult than synthesis by batch methods. Indeed, it has been considered that synthesis by flow methods can be applicable for the production of simple gasses but that it is difficult to apply to the synthesis of complex molecules such as natural products and APIs. Therefore, organic synthesis of such complex molecules has been conducted by batch methods. On the other hand, syntheses and reactions that attain high yields and high selectivities by flow methods are increasingly reported. Flow methods are leading candidates for the next generation of manufacturing methods that can mitigate environmental concerns toward sustainable society.     

Additions to non-activated alkenes: Recent advances

Non-activated olefins represent one of the most explored platform in organic synthesis affording new and useful compounds with several biological applications, among others. The typical reactivity of these compounds is the addition-type reactions. A plethora of transformations and studies were reported in the literature by many research groups. The focus of this review is to organize and describe the most recent synthetic transformations of non-activated alkenes in organic synthesis. Therefore, it is divided into five sections corresponding to each type of the products obtained: synthesis of fluoro-, chloro- and bromo-compounds; synthesis of alkyl/vinyl/aryl/heteroaryl compounds; synthesis of phospho/sulfur/silyl/cyano-compounds; synthesis of amine/amide/oxygenated compounds and synthesis of other functionalized compounds.     

Catalytic Synthesis of Some Sulfur-containing Heterocyclic Compounds. (Review)

Researches on the synthesis of sulfur-containing heterocyclic compounds at the G. K. Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, are reviewed. They include the synthesis of thiolane by the recyclization of THF in hydrogen sulfide; the synthesis thiacycloalkanes by the hydrogenation of thiophenes; the synthesis of 4-methylthiazole by the reaction of SO₂ with methylisopropylideneamine; the synthesis of thiophenes by the heterocyclization of aliphatic compounds of sulfur and dehydrogenation of thiacycloalkanes; the synthesis of thiolane 1,1-dioxide by the hydrogenation of 2- and 3-thiolene 1,1-dioxides and 3-alkoxythiolane 1,1-dioxides; the synthesis of sulfoxides by the oxidation of thiacycloalkanes with atmospheric oxygen.     

Making Solid‐Phase Peptide Synthesis Greener: A Review of the Literature

To date, the synthesis of peptides is concurrent with the production of enormous amounts of toxic waste. DMF, CH₂Cl₂, and NMP are three of the most toxic organic solvents used in chemical synthesis and are the most common solvents used for peptide synthesis. Additionally, concerns about the hepatotoxicity caused by exposure to DMF and from the toxic and allergenic nature of additives used in peptide synthesis necessitates the need for a green, environmentally friendly, and safer protocol for peptide synthesis. This review summarizes the current literature on green solid‐phase peptide synthesis successes and challenges encountered. The review concludes with suggestions for future research towards a simple and efficient green peptide synthesis protocol.     

Synthesis of eudistomin C and E: improved preparation of the indole unit

An improved synthesis of the indole unit, a key intermediate for eudistomin C, was established utilizing Makosza's indole synthesis. A concise total synthesis of eudistomin E was achieved on the basis of the improved synthesis.     

离子液体载催化剂和载试剂在有机合成中的应用

综述了离子液体载催化剂和载试剂在有机合成中的应用进展. 离子液体载催化剂是针对离子液体中催化剂难以回收利用的问题提出来的, 它不仅可以实现均相催化, 而且反应产物容易分离, 催化剂可以循环使用. 离子液体载有机试剂合成, 又称为离子液体相有机合成, 具有固相反应产物纯度高和液相反应反应快的优点. 在离子液体载无机试剂的反应中, 反应物毒性降低, 反应条件温和, 产物选择性好.     

无机纳米材料的光化学合成

无机纳米材料的合成是纳米科学发展的前提和基础之一。区别于传统的高温湿化学合成法,光化学方法在无机纳米材料的合成中表现出许多优点,并在近年来受到了广泛关注。本文分三个部分综述了近年来光化学方法在无机纳米材料合成中的应用,具体包括贵金属纳米材料的光化学合成与负载,半导体纳米材料的光化学合成以及表面等离子体共振诱导的各向异性金属纳米晶合成。最后,在总结光化学方法在无机纳米材料合成中体现出的优势及目前研究仍存在不足的基础上,我们对其未来可能的发展方向进行了展望。     

Epibatidine的全合成研究进展

概述了Ｅｐｉｂａｔｉｄｉｎｅ全合成研究的进展,全文分四部分：（１）Ｅｐｉｂａｔｉｄｉｎｅ的发现和结构的确定。（２）Ｅｐｉｂａｔｉｄｉｎｅ的全合成研究;（３）氮杂双环的合成,（４）Ｅｐｉｂａｔｉｄｉｎｅ的全合成研究进展,参考文献３４篇。     

Total synthesis of ionomycin using ring-opening strategies

[structure: see text] The total synthesis of the polyether antibiotic ionomycin, a calcium ionophore, is described. The synthesis demonstrates the utility of ring-opening methodologies as applied to the synthesis of polypropionate and deoxypolypropionate subunits, which are found in two of the four fragments in the synthesis.     

有机化学知识在高分子材料合成创新实验中的运用——分享几个实例

针对目前教学中存在的理论课程之间、实验课程与理论课程之间关联不够紧密等问题,探索了通过"知识关联"将有机化学基本知识运用到高分子材料合成创新实验中的教学思路。以新试剂合成及应用、荧光聚酯合成、聚酰胺合成、聚酯水解等为例,介绍了如何将有机化学新理论、新方法、新试剂应用于本科高分子化学和高分子材料实验教学,以及如何将有机化学的理论知识和实验手段应用于高分子材料合成教学中。实践表明:通过"知识关联",将有机化学基础理论知识和实验技能应用于高分子合成实验中可以提高学生对所学知识的理解和运用能力,增强学生的实验探索兴趣,有效改进了高分子材料合成实验教学的课堂气氛。     

A short enantioselective synthesis of (+)-eleutherin, (+)-allo-eleutherin and a formal synthesis of (+)-nocardione B

A short enantioselective synthesis of (+)-eleutherin, (+)-allo-eleutherin and the formal synthesis of (+)-nocardione B is described. The synthesis is completed in six steps in overall yields of 8% for eleutherin and 14% for allo-eleutherin. The synthetic strategy features an efficient combination of the Dötz annulation reaction with a chiral alkyne and an oxa-Pictet Spengler reaction as the keys steps in the stereodivergent synthesis of (+)-eleutherin and (+)-allo-eleutherin. The synthesis of (S)-(+)-2-(2′-hydroxypropyl)-5-methoxy-1,4-naphthoquinone entails the formal synthesis of (+)-nocardione B.     

与癌症相关的糖类抗原Globo-H六糖的全合成进展

Globo-H作为一种和乳腺癌、前列腺癌相关的复杂糖类抗原,其发现为糖类疫苗开发和癌症免疫治疗带来了机遇,但如何高效、高纯地获得合成糖类抗原,以供研究和临床应用,也向寡糖合成方法学提出了挑战.综述了1995年Danishefsky首次以糖烯组装策略全合成Globo-H以来的各种新方法,如:Schmidt的三氯乙酰亚胺酯法、Boons的双向糖苷化法、Wong的基于糖基给体活性差异的一锅煮策略、Seeberger的液相线性合成和固相自动组装法、Huang的多组份反复预活化一锅煮法和最新报道的酶法.就糖合成方法学而言,硫苷法依旧可称为"明星方法",糖烯、三氯乙酰亚胺酯和氟代糖也普遍采用,磷酸酯糖基给体在固相合成中的应用正显示出其新的活力.这些方法代表了当今糖化学的水平和发展趋势.