基于专业认证的“高分子材料与工程专业实验”课程教学改革

从工程教育专业认证要求出发,分析"高分子材料与工程专业实验"实验教学的现状及存在问题,基于专业认证视角,提出该实验课程改革的思路和方法。为更好地适应专业认证的要求,提高学生解决复杂工程问题的能力,明确了该实验课程支撑的毕业要求和指标点,在现有实验教学内容基础上,新增了与经济、环保相关度更高的实验项目,提高设计性和开放创新性实验比例,并增加了实验过程的动态评价,在提高学生解决复杂工程问题能力的同时,实现了实验教学的可持续发展。     

高分子科学实验教学培养学生创新能力的研究与实践

介绍了吉林化工学院高分子材料与工程专业基础实验的改革思路、改革方案与实施过程,讨论了如何通过专业实验教学大纲的重新编写和审定、实验教材的编写、实验用教学软件的开发、实验室开放方案和实施方案的制定等措施有效的培养和提高学生的创新能力。通过改革使得本专业的学生不仅在实验动手能力和相关实验技能方面得到加强,而且铸造了他们科学的实验思维和实验态度。     

高分子材料工程实验中培养工程能力和创新能力的研究

介绍了高分子材料工程实验课程体系的改革思路.设计了 "基本技能、综合型、设计(创新)型"多层次高分子材料工程实验体系,体现了在实验中对学生的专业基础理论、专业技术、工程能力、科学研究、创新意识的系统培养.     

LabVIEW在电导率综合检定平台的应用

采用LabVIEW图形化编程工具开发了电导率综合检测平台,该平台将多种计量仪器整合在一起,用计算机实现了检定测量工作的过程控制和数据采集的自动化.该平台以GPIB作为计算机与仪器的通讯接口,相比于其它串并口通讯,GPIB在保证高速通信的前提下,有效提高了检测平台的可靠性和稳定性.     

化学仿真实验平台在高师中学化学教法实验中的应用

通过对中学化学教法实验开设现状及存在困难的分析以及对化学仿真实验平台优势的分析,提出了将化学仿真实验平台运用于中学化学教法实验的思路和方法。实践效果表明,化学仿真实验平台在高师中学化学教法实验中具有实用价值。     

基于专业认证的“高分子浆料浆纱工艺综合实验”课程教学改革

根据工程教育专业认证要求,分析"高分子浆料浆纱工艺综合实验"课程教学的现状及存在问题,基于专业认证视角,提出该实验课程改革的思路和方法。为更好地适应专业认证要求,增强学生解决复杂工程问题的能力,明确了该课程支撑的毕业要求和课程指标点,更新了教学大纲、实验设备,新增浆料制备,以及浆液、浆膜性能测试等实验教学环节,增加设计性、创新性实验项目比例,并更新了课程考核方式,在提高学生解决复杂工程问题能力的同时,实现课程内容的可持续改进。     

有机化学实验课程在线测试与学习平台的开发与实践

通过设计开发有机化学实验课程在线测试与学习平台改进有机化学实验教学。平台基于开源考试系统设计开发,可自适应多种终端和操作系统,无需单独安装客户端。构建符合有机化学实验教学目标和需求的实验能力评测指标体系,并在此基础上搭建平台、建设标准化试题库和教学资源库。平台除了具备考试系统的基本功能外,还可以根据测试结果推送相关学习资源,实现个性化精准教学。实践证明,平台可以帮助学生掌握实验知识,帮助教师了解教学效果。     

基于随机行走的二维空间扩散模拟研究

分子的扩散行为是微观化学的重要研究领域. 影响扩散行为的因素很多,但是目前各个因素的具体影响效果还不明确. 作者基于随机行走理论建立了分子在二维空间的扩散模型,依据此模型自主开发了模拟软件以及数据分析系统,并利用该模拟软件系统研究了势垒尧横向速度等因素对扩散行为的影响,验证了该模型的可靠性,证明根据该模型可以得到和实验尧理论相吻合的结果. 该软件有望成为模拟微观化学扩散行为的潜在平台,如电化学以及膜过滤过程中的扩散.     

工程教育专业认证背景下的化工原理课程体系的建设与改革

化工原理课程体系包括化工原理、化工原理实验和化工原理课程设计三大环节,该课程体系对于培养工科学生科学的工程思维方法和工程意识、提高其工程实践技能与工程素质都具有十分重要的意义。而工程素质与实践能力是工程技术人员必须具备的重要能力。本文从三大环节入手,分别探讨了工程教育认证和新工科建设背景下对化工原理课程体系中的三门课程进行课程改革的思路和方法,从根本上提高化工原理课程体系的教学质量,培养真正能解决工程实际问题的工程技术人才。     

基于LabVIEW 7 Express的电导滴定虚拟仪器

将常规的电导率仪通过自制的调理电路连接计算机,在LabVIEW 7 Express平台上开发了电导滴定虚拟仪器,实现了电导滴定实验数据的自动记录和自动处理。将该虚拟仪器应用到多种电导滴定,实验结果的相对误差小于0.7%,大大地提高了实验结果的重现性和准确性。该虚拟仪器界面友好、操作简便,能实时绘出滴定曲线、自动处理数据及形成结果报告。     

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet–Spengler reaction

An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Understanding the Diels-Alder reactivity of 1,2-azaborine analogues

The Diels-Alder reactivity of 1,2-heteroborines (H₄C₄B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed.     

Synthesis of N-substituted carbazolones from α-iodo enaminones via Pd(0)-catalyzed intramolecular coupling under microwave irradiation

A variety of N-aryl and N-alkyl carbazolones were conveniently achieved in good to high yields via Pd₂(dba)₃-mediated intramolecular coupling of N-substituted α-iodo enaminones under microwave irradiation. The Pd(0)-catalyzed cyclization was found to proceed favorably with the more electron-deficient phenyl ring during the reactions involving unsymmetrical N,N-diaryl α-iodo enaminones. This unique property enables the construction of carbazolone skeleton containing nitro substituted benzenoid ring.     

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.