共查询到19条相似文献,搜索用时 515 毫秒
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2,3-二甲基-2-丁烯酰化合成3,3,4-三甲基-4-戊烯-2-酮的负载ZnCl2固体催化剂 总被引:1,自引:0,他引:1
研究了负载ZnCl2的固体催化剂在2,3-二甲基-2-丁烯与乙酐酰化合成3,3,4-三甲基-4-戊烯-2-酮反应中的催化活性。结果表明,K10粘土是最好的载体,但是HY沸石、Synclyst S13(一种无定型的酸性固体)、硅胶和氧化铝也都是制备负载ZnCl2的固体催化剂的有效载体。ZnCl2的负载量和改性方法都影响负载ZnCl2的固体催化剂的催化活性。 相似文献
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以2-氨基-4-甲氧基苯甲酸甲酯为原料,通过氯代反应,再分别通过酯水解反应得到化合物2-氨基-5-氯-4-甲氧基苯甲酸和2-氨基-3-氯-4-甲氧基苯甲酸。其中间体及产物结构经~1H NMR、~(13)C NMR和ESI-MS确证,并考察了最佳氯代反应条件。结果表明:物料配比为n(2-氨基-4-甲氧基苯甲酸甲酯)∶n(NCS)=1∶1. 2,反应溶剂为N,N-二甲基甲酰胺,反应时间为16 h,两种氯代产物2-氨基-5-氯-4-甲氧基苯甲酸甲酯和2-氨基-3-氯-4-甲氧基苯甲酸甲酯收率分别为47%和39%。 相似文献
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以2-氨基-5-取代苯氧甲基-1,3,4-噻二唑(1)为起始原料, 合成了中间体2-氯乙酰氨基-5-取代苯氧甲基-1,3,4-噻二唑)-2-乙酰亚胺(2)和2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-4-噻唑啉酮(3), 化合物3进一步与取代苯甲醛发生类Knoevenagle缩合反应, 得到了一系列2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-5-(取代苯基亚甲基)-4-噻唑啉酮类化合物4a~4p. 目标化合物4a~4p的结构经IR, 1H NMR和元素分析确证. 相似文献
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A. R. Jalilian M. Sheikhha M. Mirzaei G. R. Aslani A. Shafiee 《Journal of Radioanalytical and Nuclear Chemistry》2004,260(2):373-377
5-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole-2-yl-4-fluorobenzoate 6a, the non-classic benzodiazepine ligand, has been shown to elicit a significant anticonvulsant activity against pentylenetetrazole-induced
convulsion. In order to perform biological studies, we decided to prepare the [18F]-labeled compound. This compound was prepared in no-carrier-added (n.c.a) form from 5-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole-2-yl-4-N,N,N-trimethylanilinium
triflate 5 in one step at 125 °C in Kryptofix 2.2.2/[18F] and DMSO as the solvent followed by column chromatography. The synthesis took 20 minutes with an overall radiochemical
yield of 70-75% (EOS) and a specific activity about 74 GBq/mmole and chemical-radiochemical purity more than 95%.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Zarghi A Hajimahdi Z Mohebbi S Rashidi H Mozaffari S Sarraf S Faizi M Tabatabaee SA Shafiee A 《Chemical & pharmaceutical bulletin》2008,56(4):509-512
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism. 相似文献
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ZOU Kai-huang ZHANG Li-xue ** ZHANG An-jiang LEI Xin-xiang HUANG Hui-hua ZHANG Zi-yi . School of Chemistry Materials Science Wenzhou Normal College Wenzhou P. R. China . Department of Biology Chemistry Fujian Educational College Fuzhou P. R. China . College of Chemistry Chemical Engineering Lanzhou University Lanzhou P. R. China 《高等学校化学研究》2005,21(1):69-72
Introduction3,6- Disubstituted- 7H- 1 ,2 ,4- triazolo[3,4- b][1 ,3,4]thiadiazines are amongst the various hete-rocycles that received considerable attention duringthe last two decades as potential biologically activeagents.This kind of N- bridged heterocycles hasbeen reported to possess the wide spectrum of bio-logical properties,such as antimicrobial[1] ,an-tibacterial,antifungal[2 ] ,antiinflammatory[3 ] ,di-uretic[4] ,anthelmintic,and analgesic properties[5] .They can be also used as plant… 相似文献
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A series of potent and less toxic, 5‐{[((5‐substituted aryl)‐1,3,4‐thiadiazol‐2‐yl) thio]‐n‐alkyl}‐1,3,4‐oxadiazole‐2‐thiol was synthesized. Each compound was evaluated for anti‐inflammatory activity by carrageenan‐induced rat paw oedema method. Compounds PS1 , PS4 , PS9 , and PS12 showed comparatively potent anti‐inflammatory activity as compared to control as well as other test compounds. These potent compounds were also tested for acute ulcerogenic activity. Results of both studies were found statistically significant. 相似文献
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[5-(芳亚甲基氨基)-1,3,4-噻二唑-2-基]硫乙酰芳胺的合成及 生物活性研究 总被引:2,自引:0,他引:2
在K2CO3存在下利用聚乙二醇-400 (PEG-400)作相转移催化剂, 于固-液相转移催化条件下, 通过5-芳亚甲基氨 基-2-巯基-1,3,4-噻二唑与氯乙酰芳胺的硫烷基化反应, 合成了16个未见文献报道的[5-(芳亚甲基氨基)-1,3,4-噻二唑-2-基]硫乙酰芳胺衍生物. 经元素分析, FT-IR,1H NMR和13C NMR确证了其结构. 生物活性实验结果表明, 部分化合物对小麦幼苗的生长具有明显的植物生长调节活性, 并对枯草杆菌具有一定的抑制活性. 相似文献
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Afshan Banu D.E. Vasundhara Ravi S. Lamani I.A.M. Khazi Noor Shahina Begum 《Journal of Saudi Chemical Society》2013,17(2):211-217
The preparation of 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)-5-morpholin-1-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole via the intermediate 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)Imidazo[2,1-b][1,3,4] thiadiazole is described. Elemental analysis, IR spectrum, 1H NMR and X-ray crystal structure analyses were carried out to determine the compositions and molecular structures of the two compounds. The crystal packing exhibits intermolecular C–H?O, C–H?N, C–H?F and π–π stacking interactions leading to the formation of the supramolecular network. 相似文献
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芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物的合成及生物活性研究 总被引:3,自引:0,他引:3
采用活性基团拼接法, 以2-巯基-5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑为原料, 经硫醚化、肼解、腙化反应合成了8个芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物, 并经过元素分析, IR, 1H NMR, 13C NMR对其结构进行了确认. 初步生物活性测试表明, 部分化合物具有一定的抑菌生物活性. 相似文献