地方工科院校一流专业建设的探索与实践

国家一流专业“双万计划”实施以来,吉林化工学院化学与制药工程学院通过积极探索和实践,找到了一种符合自身发展定位的专业人才培养模式,显著提升了专业建设效果。本文基于教育部工程教育专业认证“学生中心、产出导向、持续改进”的理念,从立德树人落实、培养方案设计、质量保障体系构建以及人才培养模式的组织和实施等方面,论述了学院加强一流专业建设的做法以及取得的主要成效,为地方本科院校一流专业建设提供了经验和参考。     

第二届全国化学教育硕士教学技能大赛决赛会议纪要

由中国教育学会化学教学专业委员会主办,安徽师范大学化学与材料科学学院承办的“第二届全国化学教育硕士教学技能大赛决赛”于2009年8月14日至16日在安徽省芜湖市举行。来自全国各地的75名化学教育硕士和10所高等院校的17位专家、教师参加了本次会议。大赛的举行对于展示近年化学教育专业硕士研究生的培养成果,交流培养经验,提高培养质量具有重要意义。     

构建本科化学类专业特色培养方案改革与实践

构建科学且具有自我特色的专业培养方案是保障本科生培养质量的先决条件。本文结合四川大学化学学院2018级本科人才培养方案的改革与修订,从明确人才培养目标、确立专业特色和优势、改革人才培养模式及建设特色教学课程体系等方面着手,总结和提出了如何建设具有专业特色和优势人才培养方案的基本思路,对相关专业培养方案设计具有一定的借鉴意义。     

“双一流”建设背景下化学拔尖班学生的国际化培养模式探索与实践

四川大学化学学院于2009年开始实施"化学拔尖学生培养试验计划",致力于培养化学领域领军人才。在化学学科入选教育部"双一流"学科建设的背景下,学院立足本专业特点、依托校院两级资源,从师资、课程、学生、办学等多方面构建拔尖学生国际化培养体系,做出了诸多尝试并取得了良好的成效。本文在对现有国际化建设策略讨论的基础上,进一步对加强拔尖学生全球胜任力进行思考、提出建议。     

新建本科院校化学师范专业人才培养模式的探索

韶关学院化学师范本科专业以培养应用型粤北山区中学化学教师为目标定位,通过优化重组相关的专业课程体系,创建基础与专业、综合与设计、科学探究与创新实验教学平台,构建了“1个核心、2个导向、3个凸显、4个结合、5个一体、6个共同、7个适应”的人才培养模式,完成了师范生培养与中学化学教学的无缝对接,实现了教师职前师范教育与职后教育培训一体化.     

“铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目

为深入开展创新创业教育与实践,培养学生创新创业能力,提高本科生人才培养质量,进一步推动创新创业教育改革,南开大学开展了“国家级大学生创新创业训练计划”项目。化学学院结合学科自身特点,践行科教融合、理论联系实际的培养方法,不仅能够引导本科生积极参加科研训练,还能将本科生的创新结果应用于实际生产中。实现“科研反哺教学”与“教学支撑科研”这样一个相互补充、相互促进的统一体。本文介绍了一组比较典型的本科生参与“国创”项目的例子,从项目准备入手介绍了该“国创”项目的具体实施过程、同学们所遇困难及收获心得等,希望将我们积累的一些经验与化学相关专业的同学分享,助力他们更好地完成创新项目。     

化学学院专业介绍——化学生物学专业

南开大学是国内最早建立化学生物学学科、最早开展化学生物学本科生和研究生培养的高校之一。南开大学化学学院从2012年开始招收化学生物学专业本科生,迄今为止培养了5届共98名毕业生;经过多年教学实践,在化学生物学专业人才培养方面积累了经验,取得了一定成效。介绍了南开大学化学学院化学生物学本科专业的基本情况、课程设置、培养特色和目标、育人成效等。     

面向21世纪构筑高师《化学实验教学研究》课程新教学体系的初步实践

本文是高师化学专业本科生专业基础课程《化学实验教学研究》实施4年教学改革试验的阶段性总结报告,也是高等师范教育面向21世纪教学内容和课程体系改革立项内容之一。针对该课程教学体系的现状,从面向21世纪化学教师培养要求出发,我们提出本课程改革的指导思想：“培养化学实验教学意识,强化实验教学能力,提高素质,发展可持续发展能力。”在此基础上,构筑了本课程新的教学体系（含目标、内容、过程、方法、测评体系）,同时提出新的教学原则和“综合构造”教学模式。     

以科学发展观为指导 培养化学创新人才

以科学发展观为指导,剖析服务型人才创新不足的原因,明确提出什么是创新型人才。介绍了中山大学化学学院在理论课和实验课教学中培养化学创新人才的实践情况,并从理性认识和教学实践中初步总结了创新人才的培养规律和模式。提出以全面开放式本科教学,坚持“五基”教学,实践新的教学质量观作为今后教学改革的努力方向。     

硕士研究生“三级管理两层次培养”的人才培养模式探索

实践6年探索形成了“三级管理两层次培养”的理工科硕士研究生培养模式，即导师、导师团队、学院三级管理，强化学术培养与提升研究能力，注重知识应用的技能培养与提升实践能力的分层次培养。对培养过程中的各环节进行制度上的制定与完善，形成了导师民主参与、导师团队负责、学院学位评定分委员会审议、教育督导监督指导的管理体制和完善的研究生教育管理办法。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.