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1.
3-杂环基硫取代-1,3,4,5-四氢-2-氧代-苯并氮杂衍生物的合成 总被引:1,自引:0,他引:1
以芳酰肼为原料,合成了一系列3-巯基-5-芳基-1,2,4-三唑、2-巯基-5-芳基-1,3,4-噁二唑和2-巯基-5-芳基-1,3,4-噻二唑,并通过硫原子对3-溴-2-氧代-苯并氮杂3-位上的亲核取代反应将杂环化合物引入了苯并氮杂的结构当中,合成了32个新的苯并氮杂杂环衍生物.为提高其在有机溶剂中的溶解性,在苯并氮杂的N原子上引入乙酸乙酯和乙酸叔丁酯基取代基,合成了36个新衍生物.所有化合物经质谱、核磁共振谱及元素分析确证了结构并初步测定了抗菌活性. 相似文献
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以芳酰肼为原料, 合成了一系列3-巯基-5-芳基-1,2,4-三唑、2-巯基-5-芳基-1,3,4-噁二唑和2-巯基-5-芳 基-1,3,4-噻二唑, 并通过硫原子对3-溴-2-氧代-苯并氮杂3-位上的亲核取代反应将杂环化合物引入了苯并氮杂的结构当中, 合成了32个新的苯并氮杂杂环衍生物. 为提高其在有机溶剂中的溶解性, 在苯并氮杂的N原子上引入乙酸乙酯和乙酸叔丁酯基取代基, 合成了36个新衍生物. 所有化合物经质谱、核磁共振谱及元素分析确证了结构并初步测定了抗菌活性. 相似文献
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报道了2-羟基-4-氯-1-苯氧基-9,10-蒽醌的合成,并通过元素分析、核磁共振谱、质谱和红外光谱确定了结构.通过紫外-可见光谱探讨了其光致变色性以及取代基对蒽醌类化合物光致变色性的影响. 相似文献
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顺-1-环己基-3-酰氨基-4-取代苯基-2-氮杂环丁酮的合成 总被引:1,自引:0,他引:1
以取代苄叉氨基环己烷与Dane盐环化制备了23种新的单环β-内酰胺类化合物-顺-1-环己基-3-酰氨基-4-取代苯基-2-氮杂环丁酮. 并测定了合成的氮杂环丁酮类化合物的抗菌活性和抑制β-内酰胺酶的活性. 相似文献
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本文报告了利用磷试剂制备2-氧代-3-甲基-3-异丙基-3H-咪唑并[2,1-a]-1-氧代-异吲哚及其异构体3-氧代-2-甲基-2-异丙基-2H-咪唑并[2,1-a]-1-氧代-异吲哚和2-[4,5-二氢化-4-甲基-4-异丙基-5-氧代-1H-咪唑啉-2-基]-N,N-二烷基-苯甲酰胺的新方法。本文方法具有反应条件温和、反应时间较短和收率较高等特点。 相似文献
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The chemistry of two bicyclic endoperoxides, obtained by photooxygenation of 2,3-dihydro-7H-cyclohepta[1,4]dioxine and 2,3-dihydro-7H-cyclohepta[b][1,4]dioxin-7-one was investigated with the aim of synthesizing the respective tropolone derivatives. The reaction of these endoperoxides with base, thiourea and their thermolysis provided the desired tropolone derivatives in high yield. On the other hand, the thermolysis of the endoperoxide derived from 2,3-dihydro-7H-cyclohepta[b][1,4]dioxin-7-one underwent an unprecedented route and formed parent molecule and singlet oxygen instead of the expected troponoids. The formation mechanisms of all products are discussed. 相似文献
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The treatment of 4-sulfonyl derivatives of 5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-ones (I) with base was shown to result in the formation of 1,3-dihydro or 1,5-dihydro-1,4-benzodiazepin-2-ones (III and II respectively) depending upon the conditions used. The base treatment of 1-sulfonyl substituted 2,3-dihydro-1,4-benzodiazepines (V) was shown to give the vinylimines VI. 相似文献
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Photocycloaddition reactions of 3-phenyl-1,2-benzisothiazole alkenes yield derivatives of 2,3-dihydro-1,4-benzothiazepine in one step reactions. The photoadditions are both regio and stereospecific. 相似文献
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Takehiko Nishio Tatsuhiro Tokunaga Yoshimori Omote 《Journal of heterocyclic chemistry》1985,22(2):405-407
β-Sulfenyl α, β-unsaturated ketones 1a-c reacted with guanidine or amidines to give pyrimidine derivatives 3 in 14-76% yields. Treatment of ketones 1 with diamines such as ethylenediamine and o -phenylenediamine afforded the seven-membered heterocycles, 2,3-dihydro-1,4-diazepine 5 and 2,3-benzo-1,4-diazepines 8a-c . 相似文献
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A synthesis of 4-N-oxides and of 3-hydroxy derivatives of 1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-ones and of 2,3-dihydro-1H-benzofuro[3,2-e][1,4]diazepines is described. Condensation of 2-acetyl- and 2-benzoyl-3-ethoxycarbonylaminobenzofurans with acrylonitrile gave derivatives of 1,2-dihydro- and of 1,2,3,4-tetrahydrobenzofuro[3,2-b]pyridine. 相似文献
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The reaction of sulfene with N,N-disubstituted 3-aminomethylene-2,3-dihydro-4-thiochromanones and-2,3,5,6-tetrahydro-4-thiopyranones gave 1,4-cycloadducts which are derivatives of new heterocyclic systems, namely 3,4-dihydro-5H-[1]benzothiopyrano[3,4-e]-1,2-oxathiin and 3,4,7,8-tetrahydro-5H-thiopyrano[3,4-e]-1,2-oxathiin, respectively. Furthermore, some pyrazole derivatives VII and VIII were prepared from 3-hydroxymethylene-2,3-dihydro-4-thiochromanone or 2,3,5,6-tetrahydro-4-thiopyranone and hydrazines. 相似文献
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L. L. Dmitrieva L. P. Nikitina A. I. Albanov N. A. Nedolya 《Russian Journal of Organic Chemistry》2005,41(10):1430-1444
Reactions of 2-(allyloxymethyl)- and 2-[2-(vinyloxy)ethoxy]methyloxiranes with 2-propynol (~3 wt % of t-BuOK, 75–85°C, 5–10 h) lead to formation of new 1-organyloxy-3-(2-propynyloxy)propan-2-ols (yield 65–95%). On heating to 45–100°C in the presence of bases (KOH, t-BuOK), 1-allyloxy- and 1-[2-(vinyloxy)ethoxy]-3-(2-propynyloxy)propan-2-ols are transformed into the corresponding 2-vinyl-1,3-dioxolane, 6-methyl-2,3-dihydro-1,4-dioxine, 6-methylene-1,4-dioxane, and 2,3-dihydro-5H-1,4-dioxepine derivatives, whose yield and ratio strongly depend on the solvent nature, catalyst, and substituent at the hydroxy group. 2-Vinyl-1,3-dioxolane and 6-methyl-2,3-dihydro-1,4-dioxine derivatives are formed as the major products (yield 70–99%) in the presence of t-BuOK in aprotic media (toluene, THF, DMSO) or in the absence of a solvent as a result of prototropic isomerization followed by intramolecular heterocyclization. Intramolecular nucleophilic cyclization of 3-(2-propynyloxy)propan-2-ols to 6-methylene-1,4-dioxane is the predominant process in water in the presence of KOH. In all cases, the fraction of 2,3-dihydro-5H-1,4-dioxepine derivatives among the cyclization products ranges from 0 to 5% (KOH) or to 14% (t-BuOK). 相似文献
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Svetlana V. Amosova Irina A. Novokshonova Maxim V. Penzik Andrey S. Filippov Alexander I. Albanov Vladimir A. Potapov 《Tetrahedron letters》2017,58(46):4381-4383
The regioselective reaction of 2-bromomethyl-1,3-thiaselenole 1 with thiourea is accompanied by rearrangement, expanding the ring to afford the corresponding six-membered isothiuronium salt, 2-[amino(imino)methyl]sulfanyl-2,3-dihydro-1,4-thiaselenine hydrobromide 2, a synthon of the 2,3-dihydro-1,4-thiaselenin-2-ylthiolate anion. The latter was used for the synthesis of the first representatives of 2-(organylsulfanyl)-2,3-dihydro-1,4-thiaselenines 3a–g, bis(2,3-dihydro-1,4-thiaselenin-2-yl) disulfide 5 and 1,6-bis(2,3-dihydro-1,4-thiaselenin-2-ylsulfanyl)hexane 6. 相似文献
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V. V. Litvak A. S. Kondrat’ev V. D. Shteimgarts 《Russian Journal of Organic Chemistry》2009,45(11):1637-1643
The reaction of pentafluorobenzoic acid with 2-mercaptoethanol followed by modification of the reaction product by oxidationm halohydroxylation and (or) decarboxylation led to the formation of β-halo- and β-oxyethyl polyfluoroaryl sulfides, sulfoxides, and sulfones, initial compounds for the synthesis of fluorinecontaining 2,3-dihydro-1,4-benzothiazines, 2,3-dihydro-1,4-benzoxathiynes, and 2,3-dihydro-1,4-benzodithiynes and also of their S-oxides and S-dioxides based on intramolecular nucleophilic sybstitution. 相似文献
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Braulio Insuasty Alfredo Perez John Valencia Jairo Quiroga 《Journal of heterocyclic chemistry》1997,34(5):1555-1558
The reaction of 2,3,6-triaminopyridine 1 and 4,5,6-triaminopyrimidine 2 with one equivalent of the chal-cones 3, in acetic acid, leads to the formation of the 8-amino-2,3-dihydro-1H-pyrido[2,3-b][1,4]diazepine and 6-amino-2,3-dihydro-1H-pyrimido[4,5-b][1,4]diazepine derivatives 4 and 5 . The products were characterized by NMR techniques such as 13C, 1H, and DEPT including selective 13C{1H} decoupling experiments. 相似文献