| 3-甲基-4-氨基-1,2,4-三唑-5-硫酮席夫碱的合成及生物活性研究 |
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| 引用本文： | 孙晓红,陶燕,刘源发,贾婴琦,陈邦.3-甲基-4-氨基-1,2,4-三唑-5-硫酮席夫碱的合成及生物活性研究[J].化学学报,2008,66(2):234-238. |
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| 作者姓名： | 孙晓红 陶燕 刘源发 贾婴琦 陈邦 |
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| 作者单位： | 1. 西北大学化工学院化学研究所,西安,710069
2. 西北大学化学系,西安,710069 |
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| 基金项目： | 陕西省自然科学基金
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西北大学校科研和教改项目 |
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| 摘 要： | 用自制的二氨基硫脲与乙酸反应得到3-甲基-4-氨基-1,2,4-三唑-5-硫酮, 然后以醋酸为反应溶剂和催化剂, 使之与取代芳香醛反应, 合成了8个三唑类席夫碱化合物. 通过1H NMR, IR和元素分析对所有化合物进行了结构表征. 并对这些化合物进行了初步生物活性测试, 结果表明大部分化合物具有较好的抑菌活性, 并对席夫碱结构与活性的关系进行了探讨.
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| 关 键 词： | 席夫碱 三唑硫酮 合成 生物活性 |
| 收稿时间： | 2007-01-30 |
| 修稿时间： | 2007-09-10 |
Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione Schiff Bases |
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| SUN Xiao-Hong,TAO Yan,LIU Yuan-Fa,JIA Ying-Qi,CHEN Bang.Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione Schiff Bases[J].Acta Chimica Sinica,2008,66(2):234-238. |
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| Authors: | SUN Xiao-Hong TAO Yan LIU Yuan-Fa JIA Ying-Qi CHEN Bang |
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| Institution: | (College of Chemical Engineering, Chemical Research Institute, Northwest University, Xi′an 710069)(Department of Chemistry, Northwest University, Xi′an 710069) |
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| Abstract: | Thiocarbazide was reacted with acetic acid to prepare 4,5-dihydro-3-methyl-4-amino-1,2, 4-triazole-5-thione. Then eight Schiff bases were synthesized using this 1,2,4-triazole-5-thione and substituted aromatic aldehydes as starting materials, with acetic acid as a catalyst and solvent. The structures of all the compounds have been confirmed by ^1H NMR, IR and elemental analysis. Their biological activities to several vegetable pathogens have been tested and the results showed that they exhibited good fungicidal activities. |
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| Keywords: | Schiff base triazolethione synthesis biological activity |
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