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| 6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性研究 | |
| 引用本文： | 杨祖幸,陈华,毕英佐,邹燕,侯太平,王玉良.6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性研究[J].有机化学,2008,28(3):432-435. |
| 作者姓名： | 杨祖幸 陈华 毕英佐 邹燕 侯太平 王玉良 |
| 作者单位： | 1. 四川大学化学学院,成都,610064 2. 华南农业大学动物科学院,广州,510642 3. 四川大学生命科学学院,成都,610064 |
| 摘 要： | 设计并合成了10个新的6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯类化合物; 合成路线短, 产率高, 原料易得, 易实现工业化; 所有化合物的结构均经1H NMR, MS, IR和元素分析所证实; 并选择了其中7个化合物进行抗球虫活性实验, 结果表明: 其中4个6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯化合物具有抗球虫效果, 并有可能作为抗球虫药物使用. |
| 关 键 词： | 6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯 合成 抗球虫活性 |
| 收稿时间： | 2007-02-22 |
| 修稿时间： | 2007-08-20 |
Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate |
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| YANG Zu-Xing,CHEN Hua,BI Ying-Zuo,ZOU Yan,HOU Tai-Ping,WANG Yu-Liang.Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate[J].Chinese Journal of Organic Chemistry,2008,28(3):432-435. | |
| Authors: | YANG Zu-Xing CHEN Hua BI Ying-Zuo ZOU Yan HOU Tai-Ping WANG Yu-Liang |
| Institution: | (College of Chemistry, Sichuan University, Chengdu 610064)(College of Animal Science, South China Agricultural University, Guangzhou 510642)(College of Life Science, Sichuan University, Chengdu 610064) |
| Abstract: | Ten ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process has the advantages of high yield and cheap raw materials, which, thus, is convenient for the commercial production. Structures of the new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. Seven of the new compounds were chosen for the anticoccidial activity test and the result has shown that four of them have anticoccidial activity. |
| Keywords: | ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate synthesis anticoccidial activity |
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