120～430MeV/u碳离子的微剂量学特性研究（英文）

单粒子微剂量谱在放射治疗中是一个极其重要的参数,它可以用来评估辐射场的生物学效应。利用蒙特卡洛程序FLUKA模拟计算了由碳离子产生的混合辐射场能量沉积的微观模式。从已公开发表的文献中选取了实验测量300 MeV/u碳离子的线能能谱,并与相同物理条件下模拟计算得到的线能能谱相比较,结果吻合得很好。此外,还计算了120~430 MeV/u的碳离子的剂量平均线能能谱、频率平均线能和剂量平均线能。所得到的频率平均线能值为185~28.3 keV/μm而剂量平均线能值则为272~64.1 keV/μm。本文的结果对于制定碳离子放射治疗的治疗计划有着重要的意义。     

不同LET C离子束对粘红酵母菌的突变效应分析

以粘红酵母菌Rhodotorula glutinis AY 91015为材料, 研究了不同传能线密度（LET）的C离子对粘红酵母菌的失活截面和突变截面, 评估了不同LET的C离子对微生物的失活效应和突变效应。 结果表明, C离子LET为120.0 keV/μm时, 单个粒子对粘红酵母菌的失活截面最大, 为4.37 μm2, 接近酵母菌细胞核的平均核截面; LET为96.0 keV/μm时, 单个粒子对粘红酵母菌的突变截面最大。 通过对C离子束致突变能力的分析发现, C离子在LET为58.2 keV/μm时突变能力最强, 这一结果显示在经C离子辐照后存活下来的粘红酵母菌中, 可以引起有效突变的最佳LET为58.2 keV/μm左右, 此时所对应的碳离子能量约为35 MeV/u。 这些结果表明, C离子对粘红酵母菌的最佳致死效应和最佳致突变效应存在于不同的能量区域。 To evaluate inactive and mutagenic effects of carbon beam at different LET, the inactivation cross section and mutation cross section induced by carbon beams of different LET values were investigated in a red yeast strain Rhodotorula glutinis AY 91015. It was found that the maximum inactivation cross section of 4.37μm2 , which was very close to the average nucleus cross section, was at LET of 120.0 keV/μm. The maximum mutation cross section was at LET of 96.0 keV/μm. Meanwhile, the highest mutagenicity of carbon ion was found around 58.2 keV/μm. It implied that the most efficient LET to induce mutation in survival yeasts was 58.2 keV/μm, which corresponded to energy of 35 MeV/u carbon beam. The most effective carbon beam to induce inactivation and mutation located at different energy region.     

Monte Carlo simulation of carbon ion radiotherapy for the human eye

Carbon ion is the mostly common used particle in heavy ion radiotherapy. In this paper, the carbon ion dose in tumor treatment for human eye was calculated with FLUKA code. An 80 MeV/u carbon beam was irradiated into the human eye from two directions. The first was from the lateral-forward direction, which was a typical therapeutic condition. In this case, a maximum dose was deposited in the tumor volume. In the second a beam was irradiated into eyes from the forward direction to simulate a patient gazing directly into treatment beam during therapy, which may cause a certain medical accident. This method can be used for a treatment plan in heavy ion radiotherapy.     

Electron capture in collisions of Li~(3+) ions with ground and excited states of Li atoms

The electron capture processes in collisions of Li~(3+)ion with Li(1s~22s)and Li(1s~22p_(0,1))are investigated by using the two-center atomic orbital close-coupling method in the energy range from 0.1 keV/u to 300 keV/u.The interaction of the active electrons with the target ion is represented by a model potential.The present results for the Li~(3+)–Li(1s~22s)system are compared with the available theoretical data and general agreement is obtained for the high collision energies.It is also found that the total and partial electron capture cross sections are sensitive to the initial charge cloud alignment in the low energy region.     

Design of the IMP microbeam irradiation system for 100 MeV/u heavy ions

A state-of-the-art high energy heavy ion microbeam irradiation system is constructed at the Institute of Modern Physics of the Chinese Academy of Sciences. This microbeam system operates in both full current intensity mode and single ion mode. It delivers a predefined number of ions to pre-selected targets for research in biology and material science. The characteristic of this microbeam system is high energy and vertical irradiation. A quadrupole focusing system, in combination with a series of slits, has been designed to optimize the spatial resolution. A symmetrically achromatic system leads the beam downwards and serves simultaneously as an energy analyzer. A high gradient quadrupole triplet finally focuses a C^6＋ ion beam to 1 μm in the vacuum chamber within the energy range from 10 MeV/u to 100 MeV/u. In this paper, the IMP microbeam system is described in detail. A systematic investigation of the ion beam optics of this microbeam system is presented together with the associated aberrations. Comparison is made between the IMP microbeam system and the other existing systems to further discuss the performance of this microbeam. Then the optimized initial beam parameters are given for high resolution and high hitting efficiency. At last, the experiment platform is briefly introduced.     

Conceptional design of a heavy ion linac injector for HIRFL-CSRm

A room temperature heavy ion linac has been proposed as a new injector of the main Cooler Storage Ring(CSRm) at the Heavy Ion Research Facility in Lanzhou(HIRFL), which is expected to improve the performance of HIRFL. The linac injector can supply heavy ions with a maximum mass to charge ratio of 7 and an injection kinetic energy of 7.272 MeV/u for CSRm; the pulsed beam intensity is 3 emA with the duty factor of 3%. Compared with the present cyclotron injector, the Sector Focusing Cyclotron(SFC), the beam current from linac can be improved by 10–100 times. As the pre-accelerator of the linac, the 108.48 MHz 4-rod Radio Frequency Quadrupole(RFQ) accelerates the ion beam from 4 keV/u to 300 keV/u, which achieves the transmission efficiency of 95.3% with a 3.07 m long vane.The phase advance has been taken into account in the analysis of the error tolerance, and parametric resonances have been carefully avoided by adjusting the structure parameters. Kombinierte Null Grad Struktur Interdigital H-mode Drift Tube Linacs(KONUS IH-DTLs), which follow the RFQ, accelerate ions up to the energy of 7.272 MeV/u for CSRm. The resonance frequency is 108.48 MHz for the first two cavities and 216.96 MHz for the last 5 Drift Tube Linacs(DTLs). The maximum accelerating gradient can reach 4.95 MV/m in a DTL section with the length of17.066 m, and the total pulsed RF power is 2.8 MW. A new strategy, for the determination of resonance frequency,RFQ vane voltage and DTL effective accelerating voltage, is described in detail. The beam dynamics design of the linac will be presented in this paper.     

Molecular dynamics simulation of latent track formation in α-quartz

The latent ion track in α-quartz is studied by molecular dynamics simulations. The latent track is created by depositing electron energies into a cylindrical region with a radius of 3nm. In this study, the electron stopping power varies from 3.0keV/nm to 12.0keV/nm, and a continuous latent track is observed for all the simulated values of electron stopping power except 3.0keV/nm. The simulation results indicate that the threshold electron stopping power for a continous latent track lies between 3.0keV/nm and 3.7 keV/nm. In addition, the coordination defects produced in the latent track are analyzed for all the simulation conditions, and the results show that the latent track in α-quartz consists of an O-rich amorphous phase and Si-rich point defects. At the end of this paper, the influence of the energy deposition model on the latent track in α-quartz is investigated. The results indicate that different energy deposition models reveal similar latent track properties. However, the values of the threshold electron stopping power and the ion track radius are dependent on the choice of energy deposition model.     

Variation of Ionization Mechanisms with q in the Collision of He^2＋ with C^q＋

The ionization process in the collisions of He^2＋ with C^q＋ （q = 0-5） is investigated by using the continuum-distorted-wave eikonal-initial-state approximation. Double-differential cross sections for 1s and 2s sub-shells are obtained at the electron-ejected angle θ = 0° with the projectile energy ranging from 30keV/u to 10MeV/u. Variation of ionization mechanisms with q in C^q＋ is studied, and the dependences on the projectile energies and target sub-shells are also discussed. It is found that in the whole energy range, the absolute values of soft collision （SC） and binary encounter （BE） peaks decrease with increasing q. For the lower incident energies, the electron capture to the projectile continuum （ECC） peak decrease with increasing q as well as SC and BE peaks. For the higher incident energies （〉 1 MeV/u）, the absolute value of ECC peak increases with increasing q, so that the crossings of cross sections appear for C^q＋ with different q. This can be explained by the matching of velocities between the projectile and the electron initially bound to the target.     

Sequential over-barrier ionization of multi-electron atoms in the tens-to-hundreds keV/u energy range

Our previous work on the classical over-barrier ionization model for helium double ionization is extended to the complex multi-electron system of Ne.The total and q-fold ionization cross sections are calculated at energies ranging from a few tens to several hundred keV/u.The calculation results are in good agreement with the experimental data,and the energy dependence of the cross sections suggests that the multi-ionization of a strong perturbated complex atom is probably the sequential over-barrier ionization process.     

Generation of Very Energetic Ions from Intense Femtosecond Laser Interactions with Rare Gas Clusters in a Dense Jet

Very energetic ions, which are detected by time-of-flight spectrometry with maximum energy up to 1.3 MeV and an average energy of 68keV, are generated in the explosion of large Xe clusters in a dense jet irradiated with a high-intensity (～10^16 W/cm2) 50fs laser pulse from a Ti:sapphire TW laser at 79Ohm wavelength. The interaction of intense laser pulses with a jet of argon clusters is also performed and high average ion energies are observed. The dependence of energy of the ions on the gas backing pressure is examined, suggesting that the results are consistent with the absorption efficiency of the laser energy by the cluster plasmas.     

Simulation and experimental study of an indigenously designed and constructed THGEM-based microdosimeter for dose-equivalent measurement

Most of the GEM/THGEM-based microdosimetric detectors presented in the literature simulate 2 μm of tissue which results in a flat neutron dose-equivalent response in the MeV region. The objective of this work was to introduce a neutron microdosimeter with a more extended flat response. In this regard, a THGEM-based microdosimeter with plexiglas walls, simulating 1 μm of tissue was designed and constructed. Its performance was investigated by both simulation and experimentation to determine the microdosimetric quantity of “lineal energy”.In the simulation study, lineal energy distribution, mean quality factor and dose-equivalent response of the microdosimeter for eleven neutron energies from 10 keV to 14 MeV, along with the energy spectrum of ²⁴¹Am-Be neutrons, were calculated by the Geant4 simulation toolkit. Obtained lineal energy distributions were compatible with the distributions determined by a Rossi counter. Also, the mean quality factors agreed well with the values reported by the ICRU report 40 which confirmed tissue equivalent behavior of the microdosimeter. They were different from the effective quality factor values within 15% between 20 keV and 14 MeV. This led to a flat dose-equivalent response with 20% difference from a median value of 0.82 in the above energy range which was an improvement compared with other THGEM-based detectors, simulating 2 μm of tissue. In spite of the satisfactory determination of the dose-equivalent, the microdosimeter had low detection sensitivity.In the experimental study, the measured lineal energy distribution of ²⁴¹Am-Be neutrons was in agreement with the simulated distribution. Further, the measured mean quality factor and dose-equivalent differed by 1.5% and 3.5%, respectively, from the calculated values. Finally, it could be concluded that the investigated microdosimeter reliably determined the desired dose-equivalent value of each neutron field with every energy spectrum lying between 20 keV and 14 MeV.     

微束技术在放射生物学中的应用

微束装置可以为生命科学研究提供微米定位、剂量特定的电离辐射,在生物体内的电离辐射靶物质及其敏感度、靶物质的损伤及修复机制研究中具有独特的作用。概述了生物微束装置和实验技术的发展及其在低剂量辐射效应、旁观者效应、信号传导研究中的主要应用;介绍了中国科学院近代物理研究所（IMP）重离子微束装置,该装置可以提供能量7~ 80 MeV/u、传能线密度为30~ 3000 keV/μm的重离子微束,实现了活细胞辐照和在线观察、小鼠定位辐照的实验技术;利用IMP微束装置在重离子诱导旁效应实验、小鼠下丘脑重离子辐照效应和DNA损伤快速修复动态等方面取得了一些实验成果。The microbeam facility can provide micrometer scale localized and predefined ionizing radiation in the life science study, and the microbeam techniques play a unique role in determining the target substances of ionizing radiation, as well as in the study of radiation sensitivity, mechanisms of radiation damage response and repair. This paper summarizes the technical developments of biological microbeam facilities and their applications in the studies of low-dose radiation effect, bystander effect and cellular signaling. This paper also introduces the recent developments at the heavy-ion microbeam facility in the Institute of Modern Physics (IMP), which can provide heavy ion microbeam irradiation with energy of 7~80 MeV/u and LET of 30~3000 keV/μm. The facility can perform radiobiological irradiation and online investigation in living cells and mice, including bystander effect study, sleeping system influence after irradiation to mice hypothalamus and the recruitment dynamics of XRCC1 protein.     

基于TPS和蒙特卡罗计算的12C肿瘤放射治疗In-beam PET剂量监测研究

In-beam PET成像是碳离子放射治疗剂量监测的有效手段,可以对碳离子放疗过程的物理剂量分布和生物剂量分布进行实时监测。结合放射治疗计划系统(TPS)和蒙特卡罗(MC)模拟分别对静态均匀水模体和腹部肿瘤CT图像进行治疗计划设计、MC计算和PET成像,比较TPS肿瘤靶区剂量分布、MC模拟剂量分布和PET成像三者之间的一致性。TPS和MC模拟中相对生物学效应(RBE)的计算均采用线性二次模型(LQ)。研究结果显示,TPS和MC计算的静态均匀水模体、单野治疗腹部肿瘤的物理剂量、RBE加权剂量在SOBP区域的平均误差均在0.5%和2%以内。碳离子束流能量为120~400 MeV/u时,束流方向剂量深度分布与PET成像在SOBP区域的位置差异均在8 mm以内。In-beam PET可作为碳离子放射治疗中位置验证和剂量验证的有效手段。     

O~(2+)离子穿过碳膜引起的前后表面电子发射

测量了入射能为1.9~11.3 keV/u的O~(2+)离子穿过碳膜诱导的前向、后向(分别对应出射表面和入射表面)电子发射产额。实验中,通过改变入射离子的能量和流强,系统地研究了电子能损和离子束流强度对前向、后向电子发射产额的影响。结果表明,在本实验的能量范围内,前向、后向电子发射产额与对应表面的电子能损有近似的正比关系,而与束流强度无关。分析还发现引起后向电子发射的动能阈值约为0.2 keV/u,势能电子发射产额约为1 e~-/ion。     

Neutron dose measurement in carbon ion radiation therapy at HIRFL （IMP）

For radiation protection purposes, the neutron dose in carbon ion radiation therapy at the HIRFL （Heavy Ion Research Facility in Lanzhou） was investigated. The neutron dose from primary ^12C ions with a specific energy of 100 MeV/u delivered from SSC was roughly measured with a standard Anderson-Broun rem-meter using a polyethylene target at various distances. The result shows that a maximum neutron dose contribution of 19 mSv in a typically surface tumor treatment was obtained, which is less than 1% of the planed heavy ion dose and is in reasonable agreement with other reports. Also the T-ray dose was measured in this experiment using a thermo luminescent detector.     

Investigation and Application of Heavy lon Bragg Peak

Relative ionizations(Bragg curves)of 30MeV/u and 25MeV/u ⁴⁰Ar ion beams supplied by HIRFL through degraders of Mylar films with different thicknesses were measured respectively.The experimental results were compared with calculations by TRIM88 code.It is found that the experimental results are in good agreement with the calculated ones when the ⁴⁰Ar ions penetrate a smaller distance from target surface.Furthermore,a heavy ion radiotherapy planning for shallow-seated and small tumor is put forward according to the calculated relationship between intermediate energy heavy ion penetration depth in water and relative ionization.     

Dosimetry and microdosimetry of 10–220 MeV proton beams with CR-39 and their verifications by calculation of reaction cross sections using ALICE,TALYS and GEANT4 codes

High- and intermediate-energy protons are not able to directly form a track in a CR-39 etch detector (TED). Such detectors, however, can be used for the detection and dosimetry of the beams of these particles through the registration of secondary charged particles with sufficiently high values of linear energy transfer (LET). High-energy protons (72–220 MeV) and Intermediate-energy protons (10–30 MeV) with low LET values ranging from 1.1 down to 0.4 keV/μm and 5.87 down to 2.40 keV/μm, respectively are considered in this study. It seems to be sufficient to create secondary particles, although the LET values are low. This phenomenon can modify the characteristics of the energy transfer process due to these particles, which should be taken into account when such particles are used for radiobiology studies or for radiotherapy. The importance of these secondary particles was investigated experimentally by means of an LET spectrometer based on a chemically etched track detector in which the tracks of the primary protons are not revealed. Experiments were performed with proton beams available at the Nuclear Research Center for Agriculture and Medicine (NRCAM) in Karaj, Iran and at the National Cancer Center (NCC) in Seoul, Korea with protons of primary energies of about 10–30 MeV and 72–220 MeV respectively. The contribution of the secondary particle dose increases as the proton energy decreases. The origin of the secondary particles in interactions with protons having high and intermediate energies due to various nuclear reactions was calculated by the both ALICE and TALYS computer codes. The secondary microdosimetry doses were also calculated by GEANT4 code. There is large discrepancy between experimental and calculated results in low proton energies. It has been verified that there is a good correlation between the experimentally obtained results and the reaction cross sections predicted by ALICE and TALYS codes.     

High resolution resonant particle decay spectroscopy

Optimum energy resolution is being pursued in the study of the alpha particle decay spectroscopy of selected 1p-shell nuclei. Counter telescopes with two dimensional position sensitivity are used in coincidence to identify three and four-body final state reactions which proceed by sequential binary decay. Heavy ion beams at bombarding energies of 3 to 8 MeV/u from the Florida State Tandem/LINAC Accelerator Laboratory are used to initiate the reactions. Measured position and energy resolutions of the order of 1/2 % are used to provide excited state resolutions of ≈10 keV within a few hundred keV of the alpha-particle decay thresholds.     

Effects of target fragmentation on evaluation of LET spectra from space radiations: implications for space radiation protection studies

We present calculations of linear energy transfer (LET) spectra in low earth orbit from galactic cosmic rays and trapped protons using the HZETRN/BRYNTRN computer code. The emphasis of our calculations is on the analysis of the effects of secondary nuclei produced through target fragmentation in the spacecraft shield or detectors. Recent improvements in the HZETRN/BRYNTRN radiation transport computer code are described. Calculations show that at large values of LET (> 100 keV/μm) the LET spectra seen in free space and low earth orbit (LEO) are dominated by target fragments and not the primary nuclei. Although the evaluation of microdosimetric spectra is not considered here, calculations of LET spectra support that the large lineal energy (y) events are dominated by the target fragments. Finally, we discuss the situation for interplanetary exposures to galactic cosmic rays and show that current radiation transport codes predict that in the region of high LET values the LET spectra at significant shield depths (> 10 g/cm² of Al) is greatly modified by target fragments. These results suggest that studies of track structure and biological response of space radiation should place emphasis on short tracks of medium charge fragments produced in the human body by high energy protons and neutrons.