共查询到19条相似文献,搜索用时 218 毫秒
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利用Lyapunov函数研究了带有免疫反应的病毒动力学模型的全局稳定性.当基本再生数R0≤1时.病毒在体内清除;当R0>1时,病毒在体内持续生存.并且模型的正解当免疫再生数R1≤1时,趋于无免疫平衡点,当R1>1.趋于地方病平衡点. 相似文献
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重新考虑了一类带有时滞的HIV-1感染模型.运用Hale和Waltmann持续生存理论,得到了再生数R>1,系统中种群是持续生存的;通过构造Lyapunov泛函,证明了系统中平衡态的全局稳定性.得到了再生数R>1能够完全确定模型全局动力学性质. 相似文献
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《高校应用数学学报(A辑)》2021,36(3)
研究了一类具有胞内时滞,饱和感染率及饱和CTL免疫反应的HTLV-I感染动力学模型.通过计算得到了模型的两个阙值条件:病毒感染再生数和免疫反应再生数,分析了可行平衡点的存在性;通过分析特征方程根的分布讨论了可行平衡点的局部渐近稳定性;通过构造适当的Lyapunov泛函并结合LaSalle不变性原理得出:若病毒感染再生数小于1,则病毒未感染平衡点是全局渐近稳定的,病毒被清除;若免疫反应再生数小于1且病毒感染再生数大于1,则免疫未激活感染平衡点是全局渐近稳定的;若免疫反应再生数大于1,则免疫激活感染平衡点是全局渐近稳定的.最后通过对病毒感染再生数和免疫反应再生数进行敏感性分析,讨论了参数和再生数之间的相关性. 相似文献
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具有预防接种免疫力的双线性传染率SIR流行病模型全局稳定性 总被引:11,自引:0,他引:11
研究一类具有预防接种免疫力的双线性传染率 SIR流行病模型全局稳定性 ,找到了决定疾病灭绝和持续生存的阈值——基本再生数 R0 .当 R0 ≤ 1时 ,仅存在无病平衡态 E0 ;当 R0 >1时 ,存在唯一的地方病平衡态 E* 和无病平衡态 E0 .利用 Hurwitz判据及 Liapunov-Lasalle不变集原理可以得知 :当 R0 <1时 ,无病平衡态 E0 全局渐近稳定 ;当 R0 >1时 ,地方病平衡态 E*全局渐近稳定 ,无病平衡态 E0 不稳定 ;当 R0 =1时 ,计算机数值模拟结果显示 ,无病平衡态 E0 有可能是稳定的 相似文献
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《高校应用数学学报(A辑)》2021,36(2)
研究一类具有时滞和体液免疫反应的宿主体内登革热感染模型.通过分析特征方程,讨论了系统各可行平衡点的局部稳定性,得到了系统Hopf分支存在的充分条件.通过构造适当的Lyapunov函数并应用LaSalle不变性原理,证明了当基本再生数小于1时,未感染平衡点是全局渐近稳定的;当基本再生数大于1且无时滞时,得到了系统免疫激活感染平衡点全局渐近稳定的充分条件.最后,利用数值模拟验证了所得理论结果的可行性. 相似文献
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研究一类种群有迁移的流行病模型,得到了这类模型的基本再生数R0,证明了R0<1无病平衡点是局部渐近稳定的,而当R0>1时无病平衡点是不稳定的.进一步讨论了疾病持续存在与无病平衡点和地方病平衡点全局稳定的条件. 相似文献
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Yukihiko Nakata 《Journal of Mathematical Analysis and Applications》2011,375(1):14-27
In this paper, we investigate global dynamics for a system of delay differential equations which describes a virus-immune interaction in vivo. The model has two distributed time delays describing time needed for infection of cell and virus replication. Our model admits three possible equilibria, an uninfected equilibrium and infected equilibrium with or without immune response depending on the basic reproduction number for viral infection R0 and for CTL response R1 such that R1<R0. It is shown that there always exists one equilibrium which is globally asymptotically stable by employing the method of Lyapunov functional. More specifically, the uninfected equilibrium is globally asymptotically stable if R0?1, an infected equilibrium without immune response is globally asymptotically stable if R1?1<R0 and an infected equilibrium with immune response is globally asymptotically stable if R1>1. The immune activation has a positive role in the reduction of the infection cells and the increasing of the uninfected cells if R1>1. 相似文献
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具有Logistic增长和年龄结构的SIS模型 总被引:3,自引:2,他引:1
讨论具有Logistic增长和年龄结构的SIS流行病模型.运用微分、积分方程理论,得到了当再生数R0<1时,无病平衡点E0是全局渐近稳定的;当R0>1时,地方病平衡点E*是局部渐近稳定的. 相似文献
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研究具有Logistic增长和病程的SIR流行病模型.运用微分、积分方程理论,得到再生数R0<1时,无病平衡点E0是全局渐近稳定的;而当R0>1时,地方病平衡点E*是局部渐近稳定的. 相似文献
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Global analysis of virus dynamics model with logistic mitosis,cure rate and delay in virus production 下载免费PDF全文
Cruz Vargas‐De‐León Noé Chan Chí Eric Ávila Vales 《Mathematical Methods in the Applied Sciences》2015,38(4):646-664
In this paper, we study a virus dynamics model with logistic mitosis, cure rate, and intracellular delay. By means of construction of a suitable Lyapunov functionals, obtained by linear combinations of Volterra—type functions, composite quadratic functions and Volterra—type functionals, we provide the global stability for this model. If R0, the basic reproductive number, satisfies R0 ≤ 1, then the infection‐free equilibrium state is globally asymptotically stable. Our system is persistent if R0 > 1. On the other hand, if R0 > 1, then infection‐free equilibrium becomes unstable and a unique infected equilibrium exists. The local stability analysis is carried out for the infected equilibrium, and it is shown that, if the parameters satisfy a condition, the infected equilibrium can be unstable and a Hopf bifurcation can occur. We also have that if R0 > 1, then the infected equilibrium state is globally asymptotically stable if a sufficient condition is satisfied. We illustrate our findings with some numerical simulations. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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This paper investigates the effects of periodic drug treatment on a HIV infection model with two co-circulation populations of target cells. We first introduce the basic reproduction ratio for the model, and then show that the infection free equilibrium is globally asymptotically stable if R0 < 1, while the infection persists and there exists at least one positive periodic state when R0 > 1. Therefore, R0 serves as a threshold parameter for the infection. We then consider an optimization problem by shifting the phase of drug efficacy functions, which corresponds to change the dosage time of drugs in each time interval. It turns out that shifting the phase affect critically on the stability of the infection free steady state. Finally, exhaustive numerical simulations are carried out to support our theoretical analysis and explore the optimal phase shift. 相似文献
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An infection‐age virus dynamics model for human immunodeficiency virus (or hepatitis B virus) infections with saturation effects of infection rate and immune response is investigated in this paper. It is shown that the global dynamics of the model is completely determined by two critical values R 0, the basic reproductive number for viral infection, and R 1, the viral reproductive number at the immune‐free infection steady state (R 1<R 0). If R 0<1, the uninfected steady state E 0 is globally asymptotically stable; if R 0>1 > R 1, the immune‐free infected steady state E ? is globally asymptotically stable; while if R 1>1, the antibody immune infected steady state is globally asymptotically stable. Moreover, our results show that ignoring the saturation effects of antibody immune response or infection rate will result in an overestimate of the antibody immune reproductive number. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations, the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if tile immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result. 相似文献
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Global stability of a virus dynamics model with intracellular delay and CTL immune response 下载免费PDF全文
In this paper, the global stability of a virus dynamics model with intracellular delay, Crowley–Martin functional response of the infection rate, and CTL immune response is studied. By constructing suitable Lyapunov functions and using LaSalles invariance principle, the global dynamics is established; it is proved that if the basic reproductive number, R0, is less than or equal to one, the infection‐free equilibrium is globally asymptotically stable; if R0 is more than one, and if immune response reproductive number, R0, is less than one, the immune‐free equilibrium is globally asymptotically stable, and if R0 is more than one, the endemic equilibrium is globally asymptotically stable. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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Yukihiko Nakata 《Nonlinear Analysis: Theory, Methods & Applications》2011,74(9):2929-2940
In this paper, we study the global dynamics of a viral infection model with a latent period. The model has a nonlinear function which denotes the incidence rate of the virus infection in vivo. The basic reproduction number of the virus is identified and it is shown that the uninfected equilibrium is globally asymptotically stable if the basic reproduction number is equal to or less than unity. Moreover, the virus and infected cells eventually persist and there exists a unique infected equilibrium which is globally asymptotically stable if the basic reproduction number is greater than unity. The basic reproduction number determines the equilibrium that is globally asymptotically stable, even if there is a time delay in the infection. 相似文献