Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response |
| |
Authors: | LI Xiao-tong ;TIAN Xiao-hong ;XU Rui |
| |
Institution: | [1]College of Science, China University of Petroleum, Beijing 102249, China; [2]Institute of AppliedMathematics, Shijiazhuang Mechanical Engineering College, Shijiazhuang 050003, China |
| |
Abstract: | In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result. |
| |
Keywords: | |
本文献已被 CNKI 维普 等数据库收录! |
|