共查询到20条相似文献,搜索用时 15 毫秒
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本文报道了一条采用他们在研究钩吻素子全合成中所发展的一种立体选择性合成1,2,3,4-四氢-β-咔啉环系的通用方法,从而方便地合成了(-)Trypargine. 相似文献
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2-氨基-4''-溴-二苯甲酮的合成 总被引:1,自引:0,他引:1
2-氨基-4'-溴-二苯甲酮(1)是植物生长调节剂及园艺用杀菌剂异菸碱酰替苯胺的关键中间体[1] ,也是医药原料的重要中间体,可用于合成治疗眼科发炎类药物[2].文献合成路线如下: 相似文献
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Keggin型P-Mo-V杂多酸的合成 总被引:8,自引:0,他引:8
杂多化合物(Heteropolycompound,简写为HPC)的结构、性质特殊:化学计量的HPC组成简单、结构确定,既有配合物和金属氧化物的结构特征,又有酸性和氧化还原性质,多数在水和含氧有机溶剂中溶解度甚大,而且相当稳定,固态HPC的热稳定性也较好,广泛用于催化领域,在医学领域特别是抗癌及抗病毒领域也有较好的应用前景[1]。具有Keggin结构的HPC具有三级结构,其一级结构为杂多阴离子(Heteropolyanion,简写成HPAN),表达通式为[XM12O40]n-8(n为元素X的氧化数),结构描述以[XO4]四面… 相似文献
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以4-叔丁基吡啶为原料,与碘甲烷成盐后经铁氰化物氧化,在吡啶环上引入酮基,再经溴代、巯基化得标题化合物。由原料到溴代物的合成总收率达80%。 相似文献
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酶法合成头孢克罗 总被引:3,自引:0,他引:3
Enzymatic synthesis of cefaclor from 7-aminodesacetoxymethyl-3-chlorocephalosporainc acid(6-ACCA) and phenylglycine derivatives using penicillin G acylase was studied .Many factors that affect the conversion of 7-ACCA to cefaclor were examined.The immobilized enzyme from Bacillis megaterium gave a better catalytic properties and the higher conversion was obtained using phenylglycine methyl ester(PGME) as acyl donor.And the external mass transfer limitation could be eliminated when the stirring rate was more than 150r/min.Low temperature was beneficial for the synthesis and the results showed that the synthetase activity was hardly influenced by temperature while the amidase activity was affected greatly by temperature.The optimum reaction conditions were determined at pH 6.5 and 10℃,respectively.The best 7-ACCA conversion of 56% was achieved when the intial concentration of 7-ACCA and PGME was at 50 mM and 150mM,respectively. 相似文献
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以苯甲醛,碳酸氢铵和氰化钠水溶液为原料,于压力釜中通过Bucherer-Bergs反应制得苯海因,再经碱性水解得到DL-α苯甘氨酸,利用正交设计方法考察了底物,试剂用量,反应温度对反应的影响,用碳酸铵替代碳酸氢铵,收率72.6%,纯度〉98%。 相似文献