基于化学学科核心素养的“铁盐和亚铁盐”教学设计

以"铁盐和亚铁盐"教学为例，从"暖宝宝"这一情境出发，创设了"暖宝宝使用前后发生了什么变化" "使用后暖宝宝中铁元素可能存在的价态是什么、如何验证" "如何回收利用暖宝宝中的铁元素"3个问题情境，通过引导学生积极开展探究学习和问题解决，培养学生"宏观辨识与微观探析" "证据推理与模型认知" "科学探究与创新意识""科学态度与社会责任"等化学学科核心素养。     

以药物分子结构修饰为主题设计习题发展学生核心素养

以青蒿素、水杨酸、阿司匹林等药物分子结构修饰的发展史为素材设计了3组习题，分析了习题对促进学生"宏观辨识与微观探析""创新意识""模型认知""科学态度与社会责任"等化学核心素养发展的价值，论述了与素养达成目标相对应的关键能力的具体表现。     

Rasch模型在“化学键”概念教学评价中的应用研究

运用Rasch模型探查高二学生对"化学键"概念的认知情况，运用Conquest软件和Winsteps软件对测试结果进行分析。结果表明：基于Rasch模型编制的测试卷能客观有效地检测学生对"化学键"概念的理解，为一线教师的有效教学提供学情基础。     

构建“三三三”混合式课堂教学新模式——以“原子结构”类比模型的建构为例(Ⅰ)

基于在线开放课程和移动互联技术，探讨了医药类院校"无机化学"课堂教学的重构。实践中依托"一平台、一区域、六模块"，运用移动互联思维重构了三阶段、三环节、三分类的"三三三"教学新模式。进一步以"原子结构"为例介绍了课堂重构的教学设计。教学改革从学生问卷调查、考试成绩、能力培养以及学习心理等不同角度均得到非常积极的反馈，期望这一理念和实践能为新时期高校课堂教学和人才培养提供参考。     

高二学生认知结构、学科核心素养及学习困难的测量——以“卤代烃”为例

基于FLOWMAP测查高二学生"卤代烃"认知结构,并采用学科核心素养探究学生"卤代烃"学习困难。研究表明,学优生认知结构的优势体现在较高的认知"整合度"和准确率,学困生的劣势体现在较低的信息检索效率,学优生更善于运用描述及情境推理等信息处理策略建构知识。学生达到不同素养水平的学业要求差异较大。学习困难主要有不知道卤代烃的分类及物理性质,不明白或混淆发生取代反应与消去反应的特征、条件等,不知道卤代烃的用途。     

促进“科学探究与创新意识”素养发展的高三复习课——探究亚硫酸钠溶液pH的变化及应用

以“探究Na₂SO₃溶液pH的变化及应用”教学设计为例，通过课堂教学设计与实施，建构以探究物质性质及变化为目的的科学探究思维模型，在解决实际问题的过程中形成发现多因素、求证多因素、分析多因素、应用多因素的思路与方法；通过课后作业设计与实施，对已有认知模型进行反思与修正，使“教、学、评”活动有机结合，促进学生“科学探究与创新意识”化学学科核心素养的逐步发展与提升。     

利用丰富素材和创新实验发展学生化学学科核心素养* ——以“烷烃”教学为例

结合“烷烃”一课的特点及教学现状,通过丰富情境素材、创新实验设计的方式,进行教学设计。在实际教学中,激发了学生的学习兴趣,丰富了学生的感性认知,提升了学生的理解建构,发展了学生的宏观辨识与微观探析、证据推理与模型认知、科学探究与创新意识的核心素养。     

以情境-实验-问题突破传统——“二氧化硅和信息材料”的教学

针对"二氧化硅和信息材料"这部分内容在传统教学过程中存在缺乏合适的实验探究活动、教学情境素材对学生的吸引力不强、对高纯硅制备的反应原理分析不够深入等问题，通过创设真实而富有价值的问题情境（手机芯片），设计纳米二氧化硅与氢氧化钠溶液反应等实验探究活动，设计帮助学生深度理解高纯硅制备原理的问题等一系列措施进行相应的教学改进，并在此基础上展开教学实践。     

仪器分析测试技术信息化教学探索与实践

针对高职学生的特点，以仪器分析测试技术课程实训教学为例，按照课前布置学习任务，学生翻转课堂学习，"教、学、做"一体化课堂教学，课后复习巩固的形式，开展信息化教学的探索与实践，并对信息化教学的效果和存在的问题进行了分析。通过信息化教学改革，仪器分析测试技术课程突破了传统教学时空的限制，激发了学生学习的兴趣，构建了"学生主体、教师主导"的教学新模式，提高了课堂教学效果，对推动高职课堂信息化教学的改革具有一定的借鉴意义。     

借助专题复习 落实化学学科核心素养——以“金属和金属材料”为例

以“金属和金属材料”为例，通过对课标、教学内容和学情的分析，确定了基于化学学科核心素养的教学目标。通过真假黄金鉴别方案的创新设计和不同金属活动性顺序的探究，落实科学探究和创新意识的化学学科核心素养，学会基于证据的推理并建构探究不同金属活动性顺序的模型，培养学生运用化学知识解决问题的能力。通过课堂内容的梳理，拓展深化学生已有认知，树立责任意识。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.