CDIO导向的微项目驱动的《日化产品制造技术》教学研究

对日化产品制造技术课程准确定位、优化和整合,根据教学内容和教学目标科学设计微项目,融合"慕课"等多种教学资源,引导学生进行合作策略的学习,实施基于微项目驱动教学法的CDIO教学模式下的课堂翻转,转变教师职能,调动学生学习的积极性,提高学生的专业技能。     

翻转课堂模式在化学证书考试辅导中的应用

将翻转课堂教学模式引入到化学证考试辅导中,实践表明,学生对翻转课堂的接受程度很高;学生认为教师提供的教学视频对其课前学习是有用的;学生基本在课前能主动完成课前学习任务和在课中适应课堂学习活动。在较短的辅导时间内,学生对翻转课堂教学模式应用在技能操作辅导中的适应能力大于理论辅导。     

翻转课堂在医学院校卫生化学实验教学中的应用

将翻转课堂教学模式引入到预防医学专业卫生化学实验课中,以“高效液相色谱法测定饮料中的山梨酸与苯甲酸”为例分析翻转课堂设计过程,包括任务单设计、教学视频制作、课堂组织、课后评价等诸多环节。实践表明,翻转课堂的应用,激发了非化学专业学生对卫生化学实验的学习兴趣,调动了学习主动性和积极性,使学生由被动接受者变为主动探究者,而教师则由知识传授者转变为学习促进者和指导者,有利于培养学生自主学习能力和创新合作精神。     

基于小组合作学习的“线上预习–翻转课堂–课后探究”教学模式在化工原理教学中的应用

在化工原理国家一流线上课程与线上线下混合式教学基础上,开展了基于小组合作学习的线上预习–翻转课堂–课后探究的教学探索。以化工原理精馏单元操作中的塔板数简捷计算为例,对该教学模式进行阐述。通过班级分组、布置课前思考题,引导学生带着问题开展线上预习与小组合作学习,充分发挥了学生学习的主动性,大幅提高了线上预习、线下翻转课堂的教学效果与效率。通过师生翻转课堂教学与小组合作学习,使学生掌握了解决复杂工程问题的思路与方法,培养了学生解决复杂工程问题的能力。通过课后延伸问题与小组合作,引导学生课后进行学习与探究,学生建立了比现有文献适用范围宽得多的塔板数计算方程,培养了科学研究与创新能力。化工原理教学实践表明,基于小组合作学习的“线上预习–翻转课堂–课后探究”是一种较高效、通用性较强的高等工程教育教学模式。     

依托生态文明在线“金课”建设线上线下混合翻转式一流课程

基于一流课程建设的特点,依托在线一流课程,线下课堂与线上学习融合衔接,相互补充完善。采用专题引导、课堂翻转、讨论交流、学习报告、师生交流、鼓励课堂提问等教学手段解决理论与实际和自身的脱节,学生自主思辨和主动提问等问题。突破记忆知识点的试卷成绩评价,试行学生全过程参与的积分考核与评价。探索建设线上线下混合翻转式一流课程的路径。     

翻转课堂与传统课堂在高三化学教学中的对比研究

利用对比实验法,在2个平行班开展关于翻转课堂和传统课堂的对比研究。通过研究,发现翻转课堂教学模式能够激发学生的学习兴趣,提高学生的学习积极性;翻转课堂教学模式能够帮助教师发挥教学的主导作用,凸显学生学习的主体地位,能够帮助教师更好地掌握学生的学习进程;翻转课堂教学模式能有效提高学生的学习成绩。     

基于视频辅助的“翻转课堂”技术在高分子化学实验课程中的应用

在《高分子化学实验》教学过程,采用"翻转课堂"的教学理念,广泛采用视频讲义辅助教学,有效提高学生主动学习的能力,增加教学的互动性,通过多元化的实验项目设计,培养学生的分析问题、解决问题的能力,深化理论教学的效果。由于"翻转课堂"教学方式的引入,提高了学生对实验项目的领悟能力,并辅助大量的引导问题,有效实现了实验教学和理论教学的统一。通过引入视频教学的特点,有效缓解了传统实验教学中,实验仪器不足,场地紧张的难题,充分提高实验设备的使用效率。综合设计《高分子化学实验》课程的实施方式和管理制度,为视频化讲义的推广积累有益的经验。     

基于翻转课堂的有机化学教学实例

将翻转课堂应用在有机化学教学中,通过课下微视频、课堂研讨、答疑、总结等方式成功实现。根据课程性质,创建翻转课堂模式,设计学习任务单,以教材中第4章“对映异构体”为例进行教学实践,引入了先学后教、线上线下混合学习、自助化学习、PBL学习等教学新思维。结果表明,该方式能够充分调动学生学习兴趣,培养探究式学习能力,让“教”与“学”成为一个真正的有机共生体。     

项目式学习中驱动性问题的设计与实施策略——以“电离与离子反应”为例

项目式学习是落实“素养为本”的化学课堂教学的重要途径之一。驱动性问题设计是确保项目式学习高效运行的关键。驱动性问题能够驱动和组织整个项目式学习,促进学生“提出问题”能力的形成,驱动学生项目参与,引导学生进行真实问题解决。本研究结合“电离与离子反应”专题为例,对驱动性问题的类别与功能、设计原则、具体设计与实施等3个方面进行阐述,并对如何在项目式学习中进行高质量驱动性问题的设计以及如何开展基于驱动性问题的课堂教学等2个方面进行深入探讨,以期对当前基于学科核心素养的化学课堂教学有所启示。     

PBL教学法在无机化学概念性知识中的应用*

将PBL教学法结合翻转课堂的教学模式引入对无机化学概念性知识的讲解,利用超星学习通以任务清单的形式指导学生在课下完成自学,在课上进行讨论交流,促进学生的主动学习。通过实践可以发现此方法有助于形成活跃的课堂氛围并达到良好的教学效果,利于学生多种能力的培养。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.