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扁桃酸(mandelicacid)具有较强的抑菌作用,可用于治疗泌尿系统疾病,同时也是合成许多抗生素药物的中间体.因此,它在医药合成中具有广泛的用途.对扁桃酸的测定,已有紫外、HPLC、气相色谱、毛细管电泳等方法报道;电化学法测定还未见报道.本文采用现代电化学分析方法系统研究了扁桃酸在玻碳电极上的电化学行为.实验表明扁桃酸在玻碳电极上的氧化是不可逆过程,在pH 2.0介质中,在玻碳电极上都有一定的吸附性.实验研究了在pH 2.0条件下扁桃酸的各种电化学性质,并分别寻找到在不同条件下的定量方法,对实际样品进行了测定,方法简便、快速. 相似文献
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气相色谱法测定甲苯氧化产物中的苯甲醛及苯甲酸 总被引:7,自引:0,他引:7
气相色谱法测定甲苯氧化产物中的苯甲醛及苯甲酸刘敬兰,周鸿娟(河北师范大学实验中心石家庄050016)陈连文傅德才(河北经贸学院石家庄050061)(河北轻化工学院石家庄050018)1前言在由电化学间接氧化法从甲苯生产苯甲醛的反应过程中,反应条件及终点的控制直接影响着苯甲醛的回收率。苯甲醛及苯甲酸的测定方法虽已有报道〔1〕,但同时测定甲苯中两组分含量的方法尚未见报道。2实验部分(1)色谱条件:岛津气相色谱仪GC-16A,带C-R3A数据处理机。 相似文献
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紫外分光光度法测定肉桂醛、苯甲醛和苯甲酸 总被引:4,自引:0,他引:4
根据肉桂醛、苯甲醛和苯甲酸的紫外吸收光谱特征及肉桂醛和苯甲醛在228 nm和256 nm波长处有两个等吸收点,提出了测定三组分的紫外分光光度法.选择228 nm,256 nm及311 nm 3个波长作为测定波长,建立了联立方程组,求得了组分浓度与吸光度之间的关系:C内桂醛=(A311 nm-0.008 4)/0.042 4;C笨甲醛=(A256 nm-0.000 5)/0.062 2-C内桂醛;C苯甲酸=(A228 nm+0.005 7)/0.061 1-C内桂醛-C苯甲醛.相应的线性范围依次在18.03,13.08,9.233 mg·L-1以内.对方法的重现性作了试验,上述3种化合物的相对标准偏差(n=6)均小于1%.用标准加入法进行回收试验,测得其平均回收率在99.1%~100.5%之间. 相似文献
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2,6-二-O-戊基-β-环糊精涂渍Symmetry C8柱拆分扁桃酸及其类似物对映体 总被引:4,自引:0,他引:4
利用合成的2,6-二-O-戊基-β-环糊精涂渍Symmetry C8色谱柱,研究了扁桃酸及其类似物等6
种外消旋对映体的反相高效液相色谱拆分。优化了色谱分离条件,探讨了扁桃酸的手性拆分机理。结果表明,采用优化后的甲醇-水或甲醇-0.5%三乙胺-乙酸缓冲液流动相等色谱条件,扁桃酸、扁桃酸甲酯、苯基甘氨酸、苯基琥珀酸和安息香等5种外消旋对映体达到或接近基线分离,其中前4种对映体均为(S)-构型先出峰。该法可用于实际样品的对映体纯度测定。 相似文献
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以甲氧基取代苯甲醛和氯仿为起始物, 以四丁基溴化铵(TBAB)为催化剂, 在氢氧化钠溶液中反应制得甲氧基取代扁桃酸钠, 经酸化得到相应的甲氧基取代扁桃酸; 在三氟化硼-乙醚催化下, 甲氧基取代扁桃酸分别与不同的酚类化合物发生串联的酯化-分子内环合反应, 便捷、 高效地合成了13种3-芳基苯并呋喃酮类化合物. 采用噻唑蓝(MTT)法对其中11种化合物进行了肿瘤细胞增殖抑制活性研究, 结果表明化合物4a, 4j及4a, 4i具有较强的抗肿瘤活性. 相似文献
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比值导数光谱与多波长最小二乘回归分光光度法同时测定苯甲酸、苯甲醛和苯甲醇 总被引:3,自引:0,他引:3
提出了比值导数光谱多波长最小二乘回归分光光度法测定苯甲酸、苯甲醛和苯甲醇三组分混合物。合成试样4 次平行测定的相对标准偏差为0 .16 % ~4.35 % 。回收率在91 .43 % ~105.9 % 之间。 相似文献
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提出了比值导数光谱-多波长最小二乘回归分光光度法测定苯甲酸、苯甲醛和苯甲醇三组分混合物。合成试样4次平行测定的相对标准偏差为0.16%~4.35%。回收率在91.43%~105.9%之间。 相似文献
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气相色谱法测定医用苯甲酸软膏中的苯甲酸与水杨酸含量 总被引:2,自引:0,他引:2
复方苯甲酸水杨酸制剂或软膏被广泛用作外用杀菌或消毒药.近年报导的测定方法主要有薄层法[1],卡尔曼滤波分光光度法[2]与气相色谱分析法[3].用气相色谱法测定苯甲酸或水杨酸等芳香酸或取代芳香酸,多将这些酸先经各种衍生反应转变为相应的酯再进行气相色谱测定[4,5].所采用的酯化衍生反应有些较为繁琐,有些反应不够完全或引入了某些衍生试剂,给分离系统或GC分离带来一些不利影响.本文提出了一种新的丁酯衍生化前处理法.用本法测定医用苯甲酸软膏中的苯甲酸与水杨酸含量,先以75%的热乙醇溶液充分溶解软膏基质,之后用冰水骤冷使基质从乙醇溶液中析出,然后将溶液中的待测酸转变为相应丁酯并选择102硅烷化白色载体涂渍5%的SE-30填充柱对各酸丁酯进行GC分离.本法定量准确,操作也较简便. 相似文献
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An S‐mandelic acid imprinted chitosan resin was synthesized by cross‐linking chitosan with glutaraldehyde in 2% acetic acid solution. S‐Mandelic acid imprinted chitosan resin was used to enantioselectively separate racemic mandelic acid in aqueous medium. When keeping the pH of sample solution (100 mM Tris‐H3PO4) at 3.5 and adsorption time at 40 min, the enantiomer excess of mandelic acid in supernatant was 78.8%. The adsorption capacities of S‐mandelic acid imprinted chitosan resin for S‐ and R‐mandelic acid were determined to be 29.5 and 2.03 mg/g, respectively. While the adsorption capacities of non‐imprinted cross‐linked chitosan for S‐ and R‐mandelic acid were 2.10 and 2.08 mg/g, respectively. The result suggests that the imprinted caves in S‐mandelic acid imprinted chitosan resin are highly matched with S‐mandelic acid molecule in space structure and spatial arrangement of action sites. Interestingly, the enantiomer excess value of mandelic acid in supernatant after adsorption of racemic mandelic acid by R‐mandelic acid imprinted cross‐linked chitosan was 25.4%. The higher enantiomer excess value by S‐mandelic acid imprinted chitosan resin suggests that the chiral carbons in chitosan and the imprinted caves in S‐mandelic acid imprinted chitosan resin combine to play roles for the enantioselectivity of S‐mandelic acid imprinted chitosan resin toward S‐mandelic acid. Furthermore, the excellent enantioselectivity of S‐mandelic acid imprinted chitosan resin toward S‐mandelic acid demonstrates that using chiral chitosan as functional monomer to prepare molecularly imprinted polymers has great potential in enantioseparation of chiral pharmaceuticals. 相似文献
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The synthesis of alkyl aryl ketones using a mandelic acid dioxolanone as a synthetic equivalent (Umpolung) of the benzoyl carbanion is reported. The methodology involves alkylation of the mandelic acid dioxolanone, hydrolysis of the dioxolanone moiety in the alkylated products and oxidative decarboxylation of the resulting alpha-hydroxyacids. The last step is carried out in a catalytic aerobic way using a Co (III) complex in the presence of pivalaldehyde under very mild conditions. 相似文献
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The product pattern found for the dimethyldioxirane-mediated oxidation of phenylethyne strongly depends on the reaction conditions. Dimethyldioxirane generated in situ from caroate (HSO(5)(-)) and acetone in acetonitrile-water furnishes phenylacetic acid as the main product. With solutions of dimethyldioxirane in acetone, mandelic acid and phenylacetic acid are mainly formed. The relative abundances of the two acids depend on the residual water present in the dimethyldioxirane-acetone solution. Application of thoroughly dried solutions of the reagent effects increased formation of mandelic acid. When phenylethyne is oxidized by dimethyldioxirane transferred into tetrachloromethane, to minimize traces of water even further, oligomeric mandelic acid is obtained. The results are rationalized by the initial formation of phenyloxirene, which is known to equilibrate with phenylformylcarbene and benzoylcarbene. Subsequent Wolff rearrangement produces intermediate phenylketene, which can be trapped by water as phenylacetic acid or suffer from further oxidation to the alpha-lactone of mandelic acid. The alpha-lactone can either react with water to yield mandelic acid or, under anhydrous conditions, to yield oligomeric mandelic acid. In addition to mandelic acid and phenylacetic acid phenylglyoxylic acid, benzoic acid and benzaldehyde are observed as reaction products. The formation of phenylglyoxylic acid by transfer of two oxygen atoms to the unrearranged carbon skeleton of phenylethyne followed by oxygen insertion into the aldehydic C-H bond of the intermediately formed phenylglyoxal is discussed. In a second pathway this acid is formed by partial oxidation of mandelic acid. Benzaldehyde and benzoic acid are explained as products of the oxidative degradation of the alpha-lactone by dimethyldioxirane. Under in situ conditions benzoic acid is also formed by caroate initiated oxidative decarboxylation of phenylglyoxylic acid and/or intermediate phenylglyoxal. 相似文献
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对比了商品化的淀粉型手性固定相Chiralcel OJ-H和纤维素型手性固定相Chiralpak AD-H柱在正相条件下对扁桃酸系列8个化合物的拆分,结果表明Chiralcel OJ-H柱对扁桃酸系列化合物具有更强的手性识别能力,8个外消旋扁桃酸化合物在36 min内都得到了基线分离。研究发现,扁桃酸苯环上的取代基对其拆分的难易程度影响很大,其电子诱导效应影响扁桃酸类化合物在固定相上的保留时间,其空间位阻效应是扁桃酸在固定相上被拆分成败的决定因素。通过对比分析扁桃酸和手性柱的结构,探讨了可能的手性拆分机理是基于Chiralpak AD-H(Chiralcel OJ-H)手性固定相和扁桃酸系列化合物之间的氢键-氢键、偶极-偶极、π-π电子相互作用以及空间适应性等诸多因素的综合影响,其中空间适应性起到至关重要的作用。本研究可为一些实际光学活性扁桃酸及其类似物的对映体纯度测定与拆分研究提供参考。 相似文献
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Kinetic Resolution of Racemic Mandelic Acid Esters by N,N′‐Dioxide–Scandium‐Complex‐Catalyzed Enantiomer‐Selective Acylation 下载免费PDF全文
Yuheng Zhang Prof. Dr. Xiaohua Liu Lin Zhou Wangbin Wu Tianyu Huang Yuting Liao Lili Lin Prof. Dr. Xiaoming Feng 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(48):15884-15890
A simple and efficient acylative kinetic resolution of racemic mandelic acid esters was accomplished with a chiral N,N’‐dioxide–scandium(III) complex under mild and base‐free reaction conditions. A variety of mandelic acid esters performed well in the reaction, obtaining both acylated products (up to 49% yield, 97% ee) and recovered substrates (up to 49% yield, 95% ee) in high enantioselectivities with perfect selectivity factors (up to 247). The enantioselective recognition and catalytic models were also proposed for the catalytic KR reaction. 相似文献
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Golla China Malakondaiah V. M. Gurav Lekkala Amarnath Reddy Karrothu Srihari Babu Bolugoddu Vijaya Bhaskar Padi Pratap Reddy 《合成通讯》2013,43(11):1737-1744
We document an efficient and cost‐effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2‐aza‐bicyclo‐[3.3.0]‐octane‐3‐carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L‐(+)‐mandelic acid as key steps. 相似文献
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Three types of copolymers of poly(L ‐lactic acid) (PLLA) were synthesized by direct polycondensation of L ‐lactic acid and phenyl‐substituted α‐hydroxy acids (L ‐phenyllactic acid and D ‐ and L ‐mandelic acids). It was found that the glass transition temperature of the copolymers comprising L ‐mandelic acid became significantly higher (from 58 to 69 °C) with increasing content of L ‐mandelic acid (from 0 to 50 mol‐%) although the M w decreased (from 87 000 to 4 000 Da). The cast films of the L ‐mandelic acid containing copolymers showed improved tensile properties compared with those of the PLLA film. This may be due to a pinning effect of the L ‐mandelic acid units on the helix formation of PLLA, although 30% of the units were racemized. The enzymatic degradability of the L ‐mandelic acid containing copolymers was much higher than that of PLLA, as analyzed with Proteinase K® originating from Tritirachium album.