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Ru~(3+)存在下,呋塞米能够大幅度增强三(1,10-菲咯啉)钌(Ⅱ)(Ru(phen)_3~(2+))-Ce(Ⅳ)体系的化学发光,且当体系中Ru~(3+)的浓度从0增至15μmol/L时,呋塞米对体系发光的增强值提高1个数量级,基于此,建立了高灵敏测定呋塞米的Ru(phen)_3~(2+)-Ce(Ⅳ)-Ru~(3+)体系化学发光方法。在优化实验条件下,该法测定呋塞米的线性范围为5. 0×10~(-9)~2. 0×10~(-6)mol/L,检出限为3. 8×10~(-9)mol/L。方法具有较高的分析灵敏度,将其应用于呋塞米片剂和呋塞米注射液的分析,结果满意。结合紫外光谱的研究结果,对化学发光反应机理进行了探讨。 相似文献
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研究了呋塞米(FUR)在3-氨基丙基三氧基硅烷(APTS)和石墨烯(RGO)复合修饰碳糊电极(APTSRGO/CPE)上的电化学行为。实验结果表明,与CPE相比,APTS-RGO/CPE对呋塞米的电化学氧化显著增强,其氧化峰电流增加3.4倍。同时采用循环伏安法(CV)、计时电流法(CA)测定了FUR在APTS-RGO/CPE上的电极反应动力学参数,用微分脉冲伏安法(DPV)测得FUR氧化峰电流与浓度的线性范围为1.3~330 mg/L,检出限(LOD,S/N=3)为1.1×10-2mg/L。将该修饰电极应用于市售呋塞米片剂的检测,相对标准偏差(RSD)为0.4%~4.4%,回收率为98.5%~99.7%,检测结果符合电化学定量测定要求。 相似文献
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提出了Fe2+-H2O2-亚甲基蓝化学发光新体系并用于阿魏酸钠的测定。实验发现,在酸性介质中,Fe2+-H2O2体系可与亚甲基蓝反应产生极强的化学发光,阿魏酸钠对此化学发光具有显著的抑制作用。据此,结合流动注射技术,建立了阿魏酸钠化学发光分析新方法。研究了影响化学发光强度的因素,化学发光信号的降低值(ΔI)与阿魏酸钠浓度在4.5×10-6~4.5×10-5mol/L范围内呈良好的线性关系,方法的检出限为7.0×10-7mol/L。对4.8×10-6mol/L的阿魏酸钠进行了11次平行测定,其RSD=0.8%,该法已用于片剂中阿魏酸钠含量的测定。 相似文献
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在线电生强氧化剂钴(Ⅲ)化学发光法测定地塞米松磷酸钠 总被引:4,自引:0,他引:4
本文基于Co3+在硫酸介质中能氧化地塞米松磷酸钠产生化学发光这一特性,建立了一种流动注射化学发光测定地塞米松磷酸钠的新方法。其中不稳定的强氧化剂Co3+是通过在硫酸介质中恒电流电解CoSO4在线产生的,从而消除了由于试剂不稳定性带来的一些不利因素。该方法测定地塞米松磷酸钠的线性范围为1~20 mg/L,检出限为3.2×10-7g/mL(DL=3S/r),相对标准偏差小于5%。该方法已成功地用于地塞米松磷酸钠注射液中地塞米松磷酸钠的测定。 相似文献
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A simple and sensitive chemiluminescence method was developed for the determination of fenfluramine. The chemiluminescence signal arising from the reaction between alkaline luminol and N‐bromosuccinimide was found to be greatly enhanced by fenfluramine in the presence of gold nanoparticles. But fenfluramine alone slightly inhibited the CL signal of N‐bromosuccinimide‐luminol in the absence of gold nanoparticles. The experimental parameters that affected the chemiluminescence signal were thoroughly investigated. Under the optimum experimental conditions, the enhanced chemiluminescence intensity was proportional to the concentration of fenfluramine in the range of 0.005‐1.0 mg/L. The detection limit was 0.9 μg/L fenfluramine with a relative standard deviation of 2.5% for 0.1 mg/L fenfluramine solution (n = 11). The method was applied to the determination of fenfluramine in some weight‐reducing tonics and in spiked human urine. A possible CL reaction mechanism was proposed. 相似文献
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A novel chemiluminescence(CL) method is proposed for cefixime trihydrate(CFX) determination based on its eiiliancement effect on diperiodatoargentate(III)(DPA)-rhodamine 6-G(Rh6-G) reaction in conjunction with flow injection analysis(FIA). A linear calibration curve was achieved over the range from 0.01 mg/L to 2.5 mg/L CFX(R^2=0.999,n=8) with relative standard deviation(RSD) of 1.4%-3.8%(n=4)), limit of detection(LOD) of 3.0×10^-3 mg/L(S/N=3),injection tliroughput of 180/h and regression equation of y=1113.2x-14.596[y=CL intensity (mV) and x=concentration of CFX(mg/L)]. The method was successfully applied to CFX determination in pharmaceutical formulations and the recoveries(%) for proposed FI-CL and a reported spectrophotometric method by applying the Student t-test [calculated t-test value: t=1.079215, and tabulated t-distributed(95%)=2.200985] were not significantly diflerent. The CFX was efficiently extracted and no significant effect of commonly found excipients in the pharmaceutical formulations was observed. The mechanism of CL reaction is discussed briefly. 相似文献