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1.
以2-氨基-5-取代苯氧甲基-1,3,4-噻二唑(1)为起始原料, 合成了中间体2-氯乙酰氨基-5-取代苯氧甲基-1,3,4-噻二唑)-2-乙酰亚胺(2)和2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-4-噻唑啉酮(3), 化合物3进一步与取代苯甲醛发生类Knoevenagle缩合反应, 得到了一系列2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-5-(取代苯基亚甲基)-4-噻唑啉酮类化合物4a~4p. 目标化合物4a~4p的结构经IR, 1H NMR和元素分析确证. 相似文献
2.
以5-氨基-1H-1,2,4-三唑-3-羧酸乙酯为起始原料, 设计合成了11个新型的2-取代硫醚-5-(5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶基)-1,3,4-噁二唑类化合物(5)和6个新型的2-取代硫醚-5-(5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶基)-1,3,4-噻二唑类化合物(8). 通过1H NMR, MS和元素分析对所合成的化合物进行了结构表征. 初步的生物活性测试结果表明, 所合成的化合物均表现出不同程度的除草及杀菌活性, 其中化合物5k和8f的活性最好, 在50 mg/L浓度下对水稻纹枯病菌的抑制率达90%以上. 相似文献
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1,3-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]丙烷类化合物的合成 总被引:1,自引:0,他引:1
戊二酸(1)与3-芳基-4-氨基-5-巯基-1,2,4-三唑(2a~2o)在相转移催化剂四丁基碘化铵和POCl3作用下, 高收率合成了一系列新的1,2-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]丙烷(3a~3o). 其结构经IR, 1H NMR, MS和元素分析确证. 相似文献
5.
以2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(1)为起始原料, 在氢化钠作用下, 通过与羰基α-氢的Claisen缩合反应, 得到3-乙酰基-2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(2), 所得β-二酮与脲、硫脲和脒衍生物分别进行缩合关环, 生成5,6-二氢-5-氧杂-1,3-二氮杂菲衍生物3和4. 在相同的条件下, 吡喃酮1与草酸二乙酯进行缩合反应, 给出3-乙氧乙二酰 基-2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(5), 选择3-氨基吡唑、2-氨基咪唑、3-氨基三唑、2-氨基苯并咪唑和3,5-二氨基吡唑-4-偶氮苯与5缩合, 分别环合成5,6-二氢-5-氧杂-1,3-二氮杂菲并和五元含氮杂环衍生物6~10. 所合成的新化合物均经核磁共振光谱、红外光谱及元素分析证明其结构. 相似文献
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3-芳基-6-对甲苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑的合成及生物活性 总被引:2,自引:0,他引:2
利用3-芳基-4-氨基-5-巯基-1,2,4-均三唑和对甲苯甲酰异硫氰酸酯在乙腈中反应, 得到一系列3-芳基-6-对甲苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑, 用1H NMR, IR, MS和元素分析确定了其结构, 并对其进行了抗菌活性测试. 相似文献
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微波促进下3-(2-苯并呋喃基)-4-氨基-5-巯基-1,2,4-三唑 总被引:1,自引:0,他引:1
微波辐射条件下, 首先由2-苯并呋喃甲酰肼依次与二硫化碳和水合肼反应合成3-(2-苯并呋喃基)-4-氨基-5-巯基- 1,2,4-三唑, 进一步在微波辐射条件下由4-氨基-5-巯基-1,2,4-三唑分别与芳甲酸/芳氧基乙酸、α-溴代苯乙酮及芳醛反应以较高产率制得了相应的1,2,4-三唑并[3,4-b]-1,3,4-噻二唑、1,2,4-三唑并[3,4-b]-1,3,4-噻二嗪及4-芳亚甲基亚胺基-5-巯基-1,2,4-三唑. 产物结构经IR, 1H NMR, MS及元素分析进行了表征. 相似文献
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通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a~3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应, 合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a~4m. 化合物结构经元素分析, 1H NMR, IR和MS进行了表征. 抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性. 相似文献
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V. O. Kozminykh D. B. Oborin V. I. Goncharov E. N. Kozminykh 《Chemistry of Heterocyclic Compounds》2007,43(8):978-980
3-Hydroxy-3-(2-oxoethyl)-6-phenyl-2,3-dihydropyridazin-4(1H)-ones were obtained by the reaction of methyl 3-oxo-5-phenylfuran-2(3H)-ylideneacetate
or 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one with benzoic or p-nitrobenzoic isopropylidenehydrazides.
Equilibrium C(5)H and C(5)H2 tautomeric forms were detected in solutions of the 4-chlorophenyl derivatives in DMSO-d6.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1156–1158, August, 2007. 相似文献
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V. V. Dotsenko S. G. Krivokolysko E. B. Rusanov A. V. Gutov V. P. Litvinov 《Russian Chemical Bulletin》2007,56(7):1470-1473
Oxidation of (E)-3-(4-chlorophenyl)-2-cyanoprop-2-enethioamide with hydrogen peroxide or the H2O2-KOH system gave 3-(4-chlorophenyl)oxirane-2,2-dicarboxamide. This compound was also obtained by an independent “one pot”
synthesis from p-chlorobenzaldehyde and 2-cyanoacetamide through in situ oxidation of their adduct (E)-3-(4-chlorophenyl)-2-cyanoprop-2-eneamide with the H2O2-KOH system. The structure of 3-(4-chlorophenyl)oxirane-2,2-dicarboxamide was confirmed by X-ray diffraction and spectroscopic
data.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1417–1419, July, 2007. 相似文献
13.
采用减肥药盐酸西布曲明的中间体1-[1-(4-氯苯基)环丁基]-3-甲基丁胺分别与水杨醛、3,5-二氯水杨醛缩合,得到相应的席夫碱化合物2-[[1-[1-(4-氯苯基)环丁基]-3-甲基丁亚氨基]甲基]苯酚(1)和2,4-二氯-6-[[1-[1-(4-氯苯基)环丁基]-3-甲基丁亚氨基]甲基]苯酚(2).通过单晶X-射线衍射、红外光谱、核磁共振谱、元素分析等表征确定了两个席夫碱化合物的组成及结构.1是单斜晶体,空间群C2/c.2是三斜晶体,空间群P-1.化合物主要通过氢键或π-π相互作用形成超分子结构.两个席夫碱化合物具有相似的荧光性质,是潜在多功能蓝色荧光材料. 相似文献
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Chandra K. Oza Meenakshi Jain Neelima Jain Dinesh Verma 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):377-386
Twelve coordinate lanthanide (III) complexes with the general composition [Ln L3Xn(H2O)n] where Ln = Pr(III), Sm(III), Eu (III), Gd (III), Tb (III), Dy (III), X = Cl?1, NO3 ?2, n = 2–7, and L is 1-(4-chlorophenyl)-3-(4-fluoro/hydroxyphenyl)prop-2-en-1- thiosemicarbazone have been prepared. The lanthanide complexes (5) were derived from the reaction between 1-(4-chlorophenyl)-3-(4-fluoro/hydroxyphenyl)prop-2-en-1-thiosemicarbazone (4) with an aqueous solution of lanthanide salt. Chalcone thiosemicarbazone ligand (4) was prepared by the reaction of [1-(4-chlorophenyl)-3-(4-fluoro/hydroxyphenyl)]prop-2-enone (chalcone) (3) with thiosemicarbazide in the presence of hot ethanol. All the lanthanide-ligand 1:3 complexes have been isolated in the solid state, are stable in air, and characterized on the basis of their elemental and spectral data. Thiosemicarbazone ligands behave as bidentate ligands by coordinating through the sulfur of the isocyanide group and nitrogen of the cyanide residue. The probable structure for all the lanthanide complexes is also proposed. The chalcone thiosemicarbazone ligands and their lanthanide complexes have been screened for their antifungal and antibacterial studies. Some of the synthesized lanthanide complexes have shown enhanced activity compared with that of the free ligand. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
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ZHANG Shuo WANG Wenjin LI Chuan LIU Peng XU Weiren TANG Lida WANG Jianwu ZHAO Guilong 《高等学校化学研究》2014,30(2):250-256
A facile 7-step procedure for the synthesis of enantiomerically pure 1-(5-bromo-2-chlorophenyl)-1-(4-ethoxyphenyl)ethanes[(R)-2 and(S)-2] that started from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 3 was developed.The key step was the resolution of 2-(5-bromo-2-chlorophenyl)-2-(4-ethoxyphenyl)acetic acid 6 by crystallizations of its L-and D-menthyl esters 7 and 8 from petroleum ether to give optically pure enantiomers 9 and 10,respectively.The absolute configurations of the products were unambiguously determined by single-crystal X-ray diffractions of four key intermediates,9,10,13 and 14.This procedure is characterized by inexpensiveness,scalability and ability to produce two individual enantiomers of a diarylethane with unambiguously determined absolute configurations and high enantiomeric purities. 相似文献
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3-(4-Chlorophenyl)-1-phenylprop-2-en-1-one reacted with 3-amino-N-phenyl-3-thioxopropanamide under basic conditions in ethanol to give a mixture of 3-(4-chlorophenyl)-2-cyano-5-oxo-N,5-diphenylpentanamide and 3-(4-chlorophenyl)-1,5-diphenylpentane-1,5-dione. The structure of the former was determined by X-ray analysis. The reaction of the same compounds in DMSO in the presence of sodium hydroxide produced 4-(4-chlorophenyl)-N,6-diphenyl-2-thioxo-1,2,3,4-tetrahydropyridine-3-carboxamide. 相似文献
17.
Treatment of 3-(4-chlorophenyl)-7-hydroxymethyl-4,6-dimethoxyindole with 3-(4-chlorophenyl)-4,6-dimethoxyindole results in the generation of two geometrically isomeric diindolylmethanes in addition to a novel triindolyl oligomer, which has been structurally characterised. The 2,7′-diindolylmethanes were found to be unstable under Vilsmeier formylation conditions, thus hampering macrocyle precursor construction. In an alternate approach, the 3-(4-chlorophenyl)-4,6-dimethoxyindole-7-carbaldehyde was converted into the indolyl-pyrrolyl macrocycle precursor 5-(3-(4-chlorophenyl)-4,6-dimethoxyindole-2-ylmethyl)-4-ethyl-3-methylpyrrole-2,7-dicarbaldehyde, which was used to generate an unsymmetrical pentaaza macrocycle. 相似文献
18.
Song Y Zhang L Huizhong Shi D Xie J Zhao G 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,70(4):943-952
The solid phase FT-IR and FT-Raman spectra of 1-[6-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-2-[(6-chloropyridin-3-yl)methylsulfanyl]-4-methyl-1,6-dihydropyrimidin-5-yl]ethanone (C25H21Cl3N4OS) were recorded in the region 4000-400 and 3500-100cm(-1), respectively. The vibrational spectra have been computed using density functional theory (B3LYP) and ab initio molecular orbital calculation (HF) with 6-31G(d, p) basis sets. A close agreement was achieved between the observed and calculated frequency by employing normal coordinate calculations. The observed and simulated spectra were found to be well comparable. 相似文献
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1 INTRODUCTION Biginelli reaction is a three-component condensa-tion of ethyl acetoacetate, benzaldehyde and urea forthe synthesis of 3,4-dihydropyrimidin-2(1H)-ones(Scheme 1). The reaction can be carried out in aone-pot fashion in alcohol solution in t… 相似文献