| 新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性 |
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| 引用本文： | 惠新平,张艳,许鹏飞,王勤,张琪,张自义.新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性[J].有机化学,2005,25(6):700-704. |
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| 作者姓名： | 惠新平 张艳 许鹏飞 王勤 张琪 张自义 |
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| 作者单位： | [1]兰州大学功能有机分子化学国家重点实验室化学化工学院，兰州730000 [2]兰州大学生命科学学院，兰州730000 |
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| 摘 要： | 通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a～3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应, 合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑3,4-b]-1",3",4"-噻二嗪衍生物4a～4m. 化合物结构经元素分析, 1H NMR, IR和MS进行了表征. 抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性.
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| 关 键 词： | 1H-1 2 4-三唑 1 2 4-三唑[3 4-b]-1' 3' 4'-噻二嗪 抗菌活性 |
| 收稿时间： | 2004-11-9 |
| 修稿时间： | 2004年11月9日 |
Synthesis and Antibacterial Activities of Novel 4-Substituted-6- (4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1',2',4'-tri-azolo[3,4-b]- 1",3",4"-thiadiazines |
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| HUI Xin-Ping,ZHANG,Yan,XU Peng-Fei,WANG Qin,ZHANG Qi,ZHANG Zi-Yi.Synthesis and Antibacterial Activities of Novel 4-Substituted-6- (4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1'',2'',4''-tri-azolo[3,4-b]- 1",3",4"-thiadiazines[J].Chinese Journal of Organic Chemistry,2005,25(6):700-704. |
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| Authors: | HUI Xin-Ping ZHANG Yan XU Peng-Fei WANG Qin ZHANG Qi ZHANG Zi-Yi |
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| Institution: | ( State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engi-neering,Lanzhou University, Lanzhou 730000) ( College of Life Science, Lanzhou University, Lanzhou 730000) |
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| Abstract: | The synthesis of novel 4-substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-s-triazolo3,4- b]-1',3',4'-thiadiazines (4a～4m) by the condensation of 4-amino-5-mercapto-3-substituted-1,2,4-triazoles (3a～3m) with 2-bromo-2-(1H-1,2,4-triazol-1-yl)-4′-chloroacetophenone (2) was described. The structures of compounds were confirmed by elemental analyses, IR, 1H NMR and mass spectral data. These compounds have also been screened for their antibacterial activities. |
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| Keywords: | 1H-1 2 4-triazole 1 2 4-triazolo[3 4-b]-1' 3' 4'-thiadiazine antibacterial activity |
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